Does the likelihood of malignancy in thyroid nodules with RAS mutations increase in direct proportion with the allele frequency percentage?

Table 2 Pathologic results

Diagnosis	n
Benign	7*
NIFTP	2
PTC – Follicular Variant	25
Fully encapsulated	4
Partially encapsulated	13
Unencapsulated/invasive	8
PTC – Oncocytic Variant	2
PTC – Solid Variant (encapsulated)	1
Hurthle Cell Carcinoma	2

PTC Papillary thyroid cancer, NIFTP Non-invasive thyroid neoplasm with papillary-like nuclear features. *Note that in three cases there was an incidental finding of microcarcinoma separate from the biopsied nodule, and therefore were considered benign