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Table 2 Comparative analysis of the toxicity of docetaxel: original drug versus generics

From: Toxicities of docetaxel: original drug versus generics—a comparative study about 81 cases

Toxicities Original drug (n = 38) Generics (n = 43) p
Hypersensitivity 1 (2.6 %) 0 (0 %) 0.46
Peripheral sensory neuropathy 2 (5.3 %) 7 (16.3 %) 0.16
Hematological toxicities 5 (13.2 %) 14 (32.6 %) 0.04
Febrile neutropenia 1 (2.6 %) 4 (9.3 %) 0.36
Gastrointestinal toxicity 2 (5.3 %) 6 (14 %) 0.27
Skin toxicity 0 (0 %) 5 (11.6 %) 0.05
Extra nail hypermelanosis 0 (0 %) 1 (2.3 %) 1
Hand foot syndrome grade III 0 (0 %) 3 (7 %) 0.24
Ichthyosis-like eruption 0 (0 %) 1 (2.3 %) 1
Treatment discontinuation 3 (7.9 %) 17 (39.5 %) 0.001
  1. Italic values indicate statistical significants