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Table 4 List of significant differentially methylated CpGs associated with various CMD markers identified on meta-analysis

From: DNA methylation signatures associated with cardiometabolic risk factors in children from India and The Gambia: results from the EMPHASIS study

Gambian Indian Meta-analysis Gene
CpG Coef P value FDR Coef P value FDR Effect SE P value FDR Direction HetI2 HetI2
p value
 
Insulinogenic index
cg04859490 − 0.037 9.71 × 10–02 0.950 − 0.045 8.75 × 10–08 0.070 − 0.044 0.008 4.38 × 10–08 0.029 0 0.721 CPA4
cg00363845 − 0.062 8.13 × 10–06 0.284 − 0.036 5.54 × 10–04 0.711 − 0.046 0.009 7.30 × 10–08 0.029 51.7 0.150 GTPBP3/ ANO8
Pulse pressure
cg14997376 0.004 6.63 × 10–04 0.649 0.005 3.26 × 10–05 0.581 0.005 0.001 4.25 × 10–08 0.034  +  +  0 0.700 CIT
  1. Genomic coordinates are all from the hg19 build of the genome. CMD = cardiometabolic disease; Coef = regression coefficient (reported from the regressions using methylation M values); FDR = Benjamini–Hochberg false discovery rate; SE = standard error; HetI2, heterogeneity index