Spero JA, Lewis JH, Hasiba U. Disseminated intravascular coagulation. Findings in 346 patients. Thromb Haesmost. 1980;43:28–33.
Marder VJ, Feinstein DI, Colman RW, Levi M. Consumptive thrombohemorrhagic disorders. In Hemostasis and Thrombosis. Basic Principles and Clinical Practice. 5th edition. Edited by Colman RW, Marder VJ, Clowes AW, George JN, Goldhaber SZ. Philadelphia: Lippincott Williams & Wilkins; 2006;1571–1600.
Engelmann B, Massberg S. Thrombosis and intravascular effector of innate immunity. Nat Rev Immunol. 2013;13:34–45.
Hess JR, Brohi K, Dutton RP, Hauser CJ, Holcomb JB, Kluger Y, et al. The coagulopathy of trauma: a review of mechanisms. J Trauma. 2008;65:748–54.
Maegele M, Schöchl H, Cohen MJ. An up-date on the coagulopathy of trauma. Shock. 2014;41:21–5.
Gando S, Sawamura S, Hayakawa M. Trauma, shock, and disseminated intravascular coagulation. Ann Surg. 2011;254:10–9.
Gando S, Wada H, Kim HK, Kurosawa S, Nielsen JD, Thachil J, et al. Comparison of disseminated intravascular coagulation in trauma with coagulopathy of trauma/acute coagulopathy of trauma-shock. J Thromb Haemost. 2012;10:2593–5.
Gando S, Wada H, Thachil J. Differentiating disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype from coagulopathy of trauma and acute coagulopathy of trauma-shock (COT/ACOTS). J Thromb Haemost. 2013;11:826–35.
Kutcher ME, Ferguson AR, Cohen MJ. A principle component analysis of coagulation after trauma. J Trauma Acute Care Surg. 2013;74:1223–30.
Castellheim A, Brekke OL, Espevik T, Harboe M, Mollnes TE. Innate immune responses to danger signals in systemic inflammatory response syndrome and sepsis. Scand J Immunol. 2009;69:479–91.
Esmon CT. Inflammation and thrombosis. J Thromb Haemost. 2003;1:1343–8.
Esmon CT, Xu J, Lupu F. Innate immunity and coagulation. J Thromb Haemost. 2011;9:182–8.
Rivers RP, Hathaway WE, Weston W. The endotoxin-induced coagulant activity of human monocytes. Br J Haematol. 1975;30:311–6.
Müller I, Klocke A, Alex M, Kotzsch M, Luther T, Morgenstern E, et al. Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets. FASEB J. 2003;17:476–8.
McDonald B, Pittman K, Menezes GB, Hirota SA, Slaba I, Waterhouse CCM, et al. Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science. 2010;330:362–6.
Fuchs TA, Brill A, Duerschmied D, Schatzberg D, Monestier M, Myers DD, et al. Extracellular DNA traps promote thrombosis. PNAS. 2010;107:15880–5.
Fuchs TA, Bhandari AA, Wanger DD. Histones induce rapid and profound thrombocytopenia in mice. Blood. 2011;118:3708–14.
Semeraro F, Ammollo CT, Morrissey JH, Dale GL, Friese P, Esmon NL, et al. Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4. Blood. 2011;118:1952–61.
Ammollo CT, Semeraro F, Xu J, Esmon NL, Esmon CT. Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation. J Thromb Haemost. 2011;9:1795–803.
von Brühl ML, Stark K, Steinhart A, Chandraratne S, Konrad I, Lorenz M, et al. Monocytes, neutrophils, and platelet cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med. 2012;209:819–35.
Markiewski MM, Nilsson B, Ekdahl KN, Mollnes TE, Lambris JD. Complement and coagulation: strangers or partners in crime? TRENDS Immunol. 2007;28:184–92.
Kannemeier C, Shibamiya A, Nakazawa F, Trusheim H, Ruppert C, Markart P, et al. Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation. PNAS. 2007;104:6388–93.
Rapaport SI, Rao VM. Initiation and regulation of tissue factor-dependent blood coagulation. Arterioscler Thromb. 1992;12:1111–21.
Massberg S, Grahl L, von Bruehl ML, Manukyan D, Pfeiler S, Goosmann C, et al. Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases. Nat Med. 2010;16:887–96.
Ishii H, Majerus PW. Thrombomodulin is present in human plasma and urine. J Clin Invest. 1985;76:2178–81.
Ishii H, Uchiyama H, Kazama M. Soluble thrombomodulin antigen in conditioned medium is increased by damage of endothelial cells. Thromb Haemost. 1991;65:618–23.
Levi M. Disseminated intravascular coagulation. Crit Care Med. 2007;35:2191–5.
Hoffman M, Monroe III DM. A cell-based model of hemostasis. Thromb Haemost. 2001;85:958–65.
Manson J, Thiemermann C, Brohi K. Trauma alarmins as activators of damage-induced inflammation. Br J Surg. 2012;99:12–20.
Cohen MJ, Brohi K, Calfee CS, Rhan P, Chesebro BB, Christiaans SC, et al. Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion. Crit Care. 2009;13:R174.
Kutcher ME, Xu J, Vilardi RF, Ho C, Esmon CT, Cohen MJ. Extracellular histone release in response to traumatic injury: implications for compensatory role of activated protein C. J Trauma Acute Care Surg. 2012;73:1389–94.
Abrams ST, Zhang N, Manson J, Liu T, Dart C, Baluwa F, et al. Circulating histones are mediators of trauma-associated lung injury. Am J Crit Care Med. 2013;187:160–9.
Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 2010;464:104–8.
Ito T, Kawahara K, Nakamura T, Yamada S, Nakamura T, Abeyama K, et al. High-mobility group box 1 protein promotes development of microvascular thrombosis in rats. J Thromb Haemost. 2007;5:109–16.
Gando S, Nakanishi Y, Tedo I. Cytokines and plasminogen activator inhibitor-1 in posttrauma disseminated intravascular coagulation: relationship to multiple organ dysfunction. Crit Care Med. 1995;23:1835–42.
Xu J, Zhang X, Monestier M, Esmon NL, Esmon CT. Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury. J Immunol. 2011;187:2626–31.
Esmon CT. Possible involvement of cytokines in diffuse intravascular coagulation and thrombosis. Clin Haematol. 1999;12:343–59.
Boehme MWJ, Deng Y, Raeth U, Bierhaus A, Ziegler R, Stremmel W, et al. Release of thrombomodulin from endothelial cells by concerted action of TNF-alpha and neutrophils: in vivo and in vitro studies. Immunology. 1996;87:134–40.
Taylor Jr FB, Toh CH, Hoots WK, Wada H, Levi M. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001;86:1327–30.
Sawamura A, Hayakawa M, Gando S, Kubota N, Sugano M, Wada T, et al. Disseminated intravascular coagulation with a fibrinolytic phenotype at an early phase of trauma predicts mortality. Thromb Res. 2009;124:608–13.
Bakhtiari K, Meijers JCM, de Jonge E, Levi M. Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation. Crit Care Med. 2004;32:2416–21.
Gando S, Saitoh D, Ogura H, Mayumi T, Koseki K, Ikeda T, et al. Natural history of disseminated intravascular coagulation diagnosed based on the newly established diagnostic criteria for critically ill patients: results of a multicenter, prospective survey. Crit Care Med. 2008;6:145–50.
Sawamura A, Hayakawa M, Gando S, Kubota N, Sugano M, Wada T, et al. Application of the Japanese Association for Acute Medicine disseminated intravascular coagulation diagnostic criteria for patients at an early phase of trauma. Thromb Res. 2009;124:706–10.
Oshiro A, Yanagida Y, Gando S, Henzan N, Takahashi I, Makise H. Hemostasis during the early stage of trauma: comparison with disseminated intravascular coagulation. Crit Care. 2014;18:R61.
Gando S, Nanzaki S, Morimoto Y, Ishitani T, Kemmotsu O. Tissue factor pathway inhibitor does not correlate with tissue-factor induced disseminated intravascular coagulation and multiple organ dysfunction syndrome in trauma patients. Crit Care Med. 2001;29:262–6.
Petersen LC, Valentin S, Hedner U. Regulation of the extrinsic pathway system in health and disease: the role of factor VIIa and tissue factor pathway inhibitor. Thromb Res. 1995;79:1–47.
Hayakawa M, Sawamura A, Gando S, Kubota N, Uegaki S, Shimojima H, et al. Disseminated intravascular coagulation at an early phase of trauma is associated with consumption coagulopathy and excessive fibrinolysis both by plasmin and neutrophil elastase. Surgery. 2011;149:221–30.
Gando S, Nakanishi Y, Kameue T, Nanzaki S. Soluble thrombomodulin increases in patients with disseminated intravascular coagulation and in those with multiple organ dysfunction syndrome after trauma: role of neutrophil elastase. J Trauma. 1995;39:660–4.
Ogawa S, Shreeniwas R, Butura C, Brett J, Stern DM. Modulation of endothelial function by hypoxia: perturbation of barrier and anticoagulant function, and induction of a novel factor X activator. Adv Exp Med Biol. 1990;281:303–12.
Ogawa S, Gerlach H, Esposito C, Pasagian-Macaulay A, Brett J, Stern D. Hypoxia modulates the barrier and coagulant function of cultured bovine endothelium. Increased monolayer permeability and induction of procoagulant properties. J Clin Invest. 1990;85:1090–8.
Öhlin AK, Larsson K, Hansson M. Soluble thrombomodulin activity and soluble thrombomodulin antigen in plasma. J Thromb Haemost. 2005;3:976–82.
Taylor FB, Chang A, Ferrell G, Mather T, Catlett R, Blick K, et al. C4b-binding protein exacerbates the host response to Escherichia coli. Blood. 1991;78:357–63.
Engelman DT, Gabram SGA, Allen L, Ens GE, Jacobs LM. Hypercoagulability following multiple trauma. World J Surg. 1996;20:5–10.
Liaw PCY, Ferrell G, Esmon CT. A monoclonal antibody against activated protein C allows rapid detection of activated protein C in plasma and reveals a calcium ion dependent epitope involved in factor Va inactivation. J Thromb Haemost. 2003;1:662–70.
Cohen MJ, Call M, Nelson M, Calfee CS, Esmon CT, Brohi K, et al. Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients. Ann Surg. 2012;255:379–85.
Butenas S, van’t Veer C, Mann KG. ‘Normal’ thrombin generation. Blood. 1999;94:2169–78.
Grottke O, Braunschweig T, Spronk HMH, Esch S, Rieg AD, van Oerle R, et al. Increasing concentrations of prothrombin complex concentrate induce disseminated intravascular coagulation in a pig model of coagulopathy with blunt liver injury. Blood. 2011;118:1943–51.
Miller RS, Weatherford DA, Stein D, Crane MM, Stein M. Antithrombin III and trauma patients: factors that determine low levels. J Trauma. 1994;37:442–5.
Liener UC, Brückner UB, Strecker W, Steinback G, Kinzl L, Gebhard F. Trauma severity-dependent changes in ATIII activity. Shock. 2001;15:344–7.
Owings JT, Bagley M, Gosselin R, Romac D, Disbrow E. Effect of critical injury on plasma antithrombin activity: low antithrombin levels are associated with thromboembolic complications. J Trauma. 1996;41:396–406.
Gando S, Tedo I, Kubota M. Posttrauma coagulation and fibrinolysis. Crit Care Med. 1992;20:594–600.
Yanagida Y, Gando S, Hayakawa M, Sawamura A, Uegaki S, Kubota N, et al. Normal prothrombinase activity, increased systemic thrombin generation, and lower antithrombin levels in patients with disseminated intravascular coagulation at an early phase of trauma: comparison with acute coagulopathy of trauma-shock. Surgery. 2013;154:48–57.
Dunbar NM, Chandler WL. Thrombin generation in trauma patients. Transfusion. 2009;49:2652–60.
Chandler WL. Procoagulant activity in trauma patients. Am J Clin Pathol. 2010;134:90–6.
Taylor FB. Responses of anticoagulant pathways in disseminated intravascular coagulation. Semin Thromb Haemost. 2001;27:619–31.
Gando S, Nanzaki S, Sasaki S, Kemmotsu O. Significant correlations between tissue factor and thrombin markers in trauma and septic patients with disseminated intravascular coagulation. Thromb Haemost. 1998;79:1111–5.
Ogura H, Kawasaki T, Tanaka H, Koh T, Tanaka R, Ozeki Y, et al. Activated platelets enhance microparticle formation and platelet-leucocyte interaction in severe trauma and sepsis. J Trauma. 2001;50:801–9.
Nakashima M, Uematsu T, Umemura K, Maruyama I, Tsuruta K. A novel recombinant human soluble thrombomodulin, ART-123, activates the protein C pathway in healthy male volunteers. J Clin Pharmacol. 1998;38:540–4.
Mohri M, Sata M, Gomi K, Maruyama Y, Osame M, Maruyama I. Abnormalities in the protein C anticoagulant pathway detected by a novel assay using human thrombomodulin. Lupus. 1997;6:590–6.
Giles AR, Nesheim ME, Mann KG. Studies of Factors V and VIII:C in an animal model of disseminated intravascular coagulation. J Clin Invest. 1984;74:2219–25.
Wyshock EG, Sufferendini AF, Parrillo JE, Colman RE. Cofactors V and VIII after endotoxin administration to human volunteers. Thromb Res. 1995;80:377–89.
Hiippala S. Replacement of massive blood loss. Vox Sang. 1998;74:399–407.
Lowenstein CJ, Morrell CN, Yamakuchi M. Regulation of Weibel-Palade body exocytosis. Trend Cardivasc Med. 2005;15:302–8.
Terraube V, O'Donnell JS, Jenkins PV. Factor VIII and von Willebrand factor interaction: biological, clinical and therapeutic importance. Haemophilia. 2010;16:3–13.
Clarke BJ, Sridhara S, Woskowska Z, Blajchman MA. Consumption of plasma factor VII in a rabbit model of non-overt disseminated intravascular coagulation. Thromb Res. 2003;108:329–34.
Gando I, Makise H, Tedo I. Variation in wound healing factors in trauma patients. Jp J Surg. 1990;91:17–22.
McKay DG. Trauma and disseminated intravascular coagulation. J Trauma. 1969;9:646–60.
Flute PT. Coagulation and fibrinolysis after injury. J Clin Pathol. 1970;23:102–9.
Risberg B. Fibrinolysis in trauma. Eur Surg Res. 1978;10:373–81.
Raza I, Davenport R, Rourke C, Platton S, Manson J, Spoors C, et al. The incidence and magnitude of fibrinolytic activation in trauma patients. J Thromb Haemost. 2013;11:307–14.
Stump DC, Taylor FBJ, Nesheim ME, Giles AR, Dzik WH, Bovill EG. Pathologic fibrinolysis as a cause of clinical bleeding. Semin Thromb Hemost. 1990;16:260–73.
Levi M, ten Cate H, van der Poll T, van Daventer SJH. Pathogenesis of disseminated intravascular coagulation in sepsis. JAMA. 1993;270:975–9.
Gando S, Kameue T, Nanzaki S, Nakanishi Y. Massive fibrin formation with consecutive impairment of fibrinolysis in patients with out-of-hospital cardiac arrest. Thromb Hemost. 1997;77:278–82.
Hayakawa M, Gando S, Ieko M, Honma Y, Homma T, Yanagida Y, et al. Massive amount of tissue factor induce fibrinogenolysis without tissue hypoperfusion in rats. Shock. 2013;39:514–9.
Gando S. Microvascular thrombosis and multiple organ dysfunction syndrome. Crit Care Med. 2010;38:S35–42.
Bergentz SE, Leandoer L. Disseminated intravascular coagulation in shock. Ann Chir Gynecol Fenn. 1971;60:175–9.
Turpini R, Stefanini M. The nature and mechanism of the hemostatic breakdown in the course of experimental hemorrhagic shock. J Clin Invest. 1959;38:53–65.
Borgström S, Gelin LE, Zederfeldt B. The formation of vein thrombi following tissue injury. An experimental study in rabbits. Act Chir Scand 1959;Suppl 247:1–36.
Allardyce B, Hamit HF, Matsumoto T, Moseley RV. Pulmonary vascular changes in hypovolemic shock: radiography of the pulmonary microcirculation and the possible role of platelet embolism in increasing vascular resistance. J Trauma. 1999;9:403–11.
Lungqvist U, Bergentz SE, Lewis DH. The distribution of platelets, fibrin and erythrocytes in various organs following experimental trauma. Eur Surg Res. 1971;3:293–300.
Leandoer L, Bergentz SE. Haemorrhagic shock in the dog. The formation of thromboemboli during antifibrinolytic therapy. Eur Surg Res. 1970;2:341–7.
Avikainen V, Eklund B. Disseminated intravascular coagulation after inhibition of fibrinolysis with tranexamic acid (AMCA) and proteinase inhibitor trasylol in experimental traumatic and haemorrhagic shock. Ann Chir Gynecol Fenn. 1974;63:226–34.
Hardaway RM. The significance of coagulative and thrombotic changes after haemorrhage and injury. J Clin Pathol (R Coll Pathol). 1970;4:110–20.
Nuytinck HK, Offermans XJ, Kubat K, Goris JA. Whole-body inflammation in trauma patients. An autopsy study. Arch Surg. 1988;123:1519–24.
Rizoli S, Nascimento B, Key N, Tien HC, Muraca S, Pinto R, et al. Disseminated intravascular coagulopathy in the first 24 hours after trauma: the association between ISTH score and anatomopathologic evidence. J Trauma. 2011;71:S441–7.
Parr MJ, Bouillon B, Brohi K, Dutton RP, Hauser CJ, Hess JR, et al. Traumatic coagulopathy: where are the good experimental models? J Trauma. 2008;65:766–71.
Frith D, Cohen MJ, Brohi K. Animal models of trauma-induced coagulopathy. Thromb Res. 2012;129:551–6.
Gentile LF, Nacionales DC, Cuenca AG, Armbruster MA, Ungaro RF, Abouhamze AS, et al. Identification and description of a novel murine model for polytrauma and shock. Crit Care Med. 2013;41:1075–85.
Tanabe K, Yoshitake J. A study on coagulation and fibrinolytic dynamics in experimental traumatic shock. Masui (Jp J Anesthesiol). 1981;30:826–31.
Kugimiya H. A pathophysiological and biochemical study on the experimental traumatic shock in rats. A relationship between coagulation/fibrinolytic system and DIC. Masui (Jp J Anesthesiol) 1982;31:75–84.
Armstead VE, Opetanova IL, Minchenko AG, Lefer AM. Tissue factor expression in vital organs during murine traumatic shock. Anesthesiology. 1999;91:1844–52.