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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: GPR65 sensing tumor-derived lactate induces HMGB1 release from TAM via the cAMP/PKA/CREB pathway to promote glioma progression

Fig. 4The alternative text for this image may have been generated using AI.

GPR65 was the principal receptor mediating lactate stimulation in TAMs in glioma. A Differential mRNA expression levels of GPR65 among GBM, LGG, and Normal groups in TCGA dataset. B Kaplan–Meier survival curves for correlation between GPR65 mRNA expression and survival of glioma patients in the TCGA dataset. C Western blot analysis and quantification of GPR65 protein expression in clinical samples. D-E Cellular distribution of GPR65 in glioma using single-cell RNA-seq datasets from UCSC Cell Browser (https://gbm.cells.ucsc.edu) and Single Cell Portal (https://singlecell.broadinstitute.org, GSE131928). F Representative pictures and quantification for immunofluorescence staining of clinical tissues for GPR65, and / CD68 or CD206. Data are presented as the Mean ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001

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