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Table 3 BED3 and toxicity characteristics for all patients receiving re-irradiation

From: An algorithm for thoracic re-irradiation using biologically effective dose: a common language on how to treat in a “no-treat zone”

Organ at risk BED3 composite, mean (range) Re-SABR toxicity, n (%)
(n = 14)
CRT after SABR toxicity, n (%)
(n = 24)
Total toxicity, n (%)
(n = 38)
Spinal cord Max: 40 Gy
(5 Gy- 91 Gy)
D1cc: 34 Gy
(1 Gy- 63 Gy)
0 (0%) 0 (0%) 0 (0%)
Trachea - 0 (0%) 0 (0%) 0 (0%)
Proximal bronchial tree Max: 133 Gy
(7 Gy- 253 Gy)
D1cc: 108 Gy
(2 Gy- 220 Gy)
0 (0%) 0 (0%) 0 (0%)
Aorta Max: 120 Gy (22 Gy – 332 Gy)
D1cc: 105 Gy
(15 Gy – 242 Gy)
0 (0%) 0 (0%) 0 (0%)
Pulmonary artery Max: 114 Gy
(2 Gy – 395 Gy)
D1cc: 101 Gy
(1 Gy – 284 Gy)
0 (0%) 0 (0%) 0 (0%)
Superior vena cava Max: 89 Gy
(6 Gy – 184 Gy)
D1cc: 77 Gy
(40 Gy – 162 Gy)
0 (0%) 0 (0%) 0 (0%)
Brachial plexus Max: 16 Gy
(0 Gy – 145 Gy)
D0.2 cc: 13 Gy
(0 Gy – 123 Gy)
Brachial plexopathy
G2 n = 1 (7%)
Brachial plexopathy
n = 0 (0%)
Brachial plexopathy
G2 n = 1 (3%)
Chest wall Max: 320 Gy
(62 Gy – 568 Gy)
D30cc: 145 Gy
(39 Gy – 339 Gy)
D50cc: 116 Gy
(33 Gy – 308 Gy)
Dermatitis
G1 n = 1 (7%)
CW pain
G1 n = 1 (7%)
G2 n = 1 (7%)
G3 n = 1 (7%)
Rib fracture
G2 n = 3 (21%)
Dermatitis
G1 n = 5 (21%)
G2 n = 1 (4%)
CW pain
G1 n = 2 (8%)
G2 n = 3 (13%)
Rib fracture
G2 n = 2 (8%)
Dermatitis
G1 n = 6 (16%)
G2 n = 1 (3%)
CW pain
G1 n = 3 (8%)
G2 n = 4 (11%)
G3 n = 1 (3%)
Rib fracture
G2 n = 5 (13%)
Esophagus Mean: 24 Gy
(1 Gy – 67 Gy)
Max: 94 Gy
(5 Gy – 218 Gy)
D30cc: 73 Gy
(1 Gy – 190 Gy)
D50cc: 65 Gy
(1 Gy – 174 Gy)
Fatigue
G1 n = 5 (36%)
G2 n = 1 (7%)
Esophagitis
n = 0 (0%)
Fatigue
G1 n = 10 (42%)
G2 n = 3 (13%)
Esophagitis
G1 n = 11 (46%)
G2 n = 4 (17%)
Fatigue
G1 n = 15 (39%)
G2 n = 4 (11%)
Esophagitis
G1 n = 11 (29%)
G2 n = 4 (1%)
Heart Mean: 11 Gy
(0 Gy – 58 Gy)
Max: 98 Gy
(1 Gy – 280 Gy)
D5cc: 64 Gy
(0 Gy – 132 Gy)
D40cc: 36 Gy
(0 Gy –111 Gy)
0 (0%) 0 (0%) 0 (0%)
Total lung Mean: 23 Gy
(6 Gy – 50 Gy)
Max: 434 Gy
(100 Gy – 729 Gy)
V5Gy: 43.6%
(16.2% – 86.9%)
V20Gy: 24.6%
(8.7% – 46.3%)
V35Gy: 18.6%
(3.5% – 39.7%)
Dyspnea
G1 n = 7 (50%)
G2 n = 3 (21%)
G3 n = 1 (7%)
Cough
G1 n = 6 (43%)
Pneumonitis
G2 n = 1 (7%)
G3 n = 1 (7%)
Dyspnea
G1 n = 2 (8%)
G2 n = 2 (8%)
G3 n = 2 (8%)
Cough
G1 n = 8 (33%)
G2 n = 1 (4%)
Pneumonitis
G1 n = 6 (25%)
G3 n = 2 (8%)
Dyspnea
G1 n = 9 (24%)
G2 n = 5 (13%)
G3 n = 3 (8%)
Cough
G1 n = 14 (37%)
G2 n = 1 (3%)
Pneumonitis
G1 n = 6 (16%)
G2 n = 1 (3%)
G3 n = 3 (8%)