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Table 2 Dosimetric characteristics of patients experiencing selected grade 2–3 toxicities from repeat SABR and CRT

From: An algorithm for thoracic re-irradiation using biologically effective dose: a common language on how to treat in a “no-treat zone”

Organ at risk (OAR) Grade and number (%) of re-SABR toxicity Composite BED3 or % corresponding to Re-SABR toxicity, mean (range) Grade and number (%) of re-CRT toxicity Composite BED3 or % corresponding to toxicity, mean (range)
Brachial plexus     
Dmax
D0.2 cc
Grade 2 brachial plexopathy, n = 1 (7%) 144 Gy
123 Gy
- -
Chest wall     
Dmax
D30cc
D50cc
Grade 2 rib fracture, n = 3 (21%) 370 Gy (288–432)
225 Gy (166–339)
187 (122–308)
Grade 2 rib fracture, n = 2 (8%) 403 Gy (353–452)
209 Gy (175–243)
139 (100–177 Gy)
Chest wall     
Dmax
D30cc
D50cc
Grade 2 chest wall pain, n = 1 (7%) 411 Gy
107 Gy
83 Gy
Grade 2 chest wall pain, n = 3 (13%) 386 Gy (353–452)
243 Gy (175–310)
177 Gy (100–255)
Dmax
D30cc
D50cc
Grade 3 chest wall pain, n = 1 (7%) 390 Gy
339 Gy
308 Gy
- -
Total Lung     
Mean
Dmax
V5
V20
V35
Mean
Dmax
V5
V20
V35
Grade 2 pneumonitis, n = 1 (7%)
Grade 3 pneumonitis, n = 1 (7%)
15 Gy
451 Gy
32%
13%
10%
35 Gy
481 Gy
32%
23%
20%
Grade 2 pneumonitis, n = 1 (4%)
Grade 3 pneumonitis, n = 2 (8%)
29 Gy
382 Gy
67%
33%
25%
21 Gy (20–22)
391 (332–449)
36% (34–37)
24% (23–25)
19% (18–19)
Total lung     
Mean
Dmax
V5
V20
V35
Grade 2 dyspnea, n = 3 (21%) 24 Gy (11–33)
487 Gy (377–622)
49% (23–77)
27% (11–45)
17% (7–25)
Grade 2 dyspnea, n = 2 (8%) 33 Gy (32–34)
444 Gy (362–526)
62% (55–68)
36% (30–41)
28% (24–31)
Mean
Dmax
V5
V20
V35
Grade 3 dyspnea, n = 1 (7%) 35 Gy
481 Gy
32%
23%
20%
Grade 3 dyspnea, n = 2 (8%) 26 Gy (22–29)
416 Gy (382–449)
52% (37–67)
28% (23–33)
22% (19–25)