Correction: Journal of Neuroinflammation (2023) 20:214 https://doi.org/10.1186/s12974-023-02895-7
In this article, the paragraph beginning with “More examples of….” were corrected. The corrected papragraph is given below.
More examples of divergent results have arisen from modeling of therapeutic intervention using anti-TREM2 antibodies. Antibody 4D9 blocks shedding of sTREM2, activates protective TREM2 signaling, and improves pathology in a mouse model of AD amyloidopathy [17]. Agonistic antibodies such as 4D9 and others are currently being tested in clinical trials [17, 18]. It is worth noting that while TREM2-activating antibodies show promise in reducing amyloid burden at early stages, if treatment is continued into later stages of pathology, TREM2 agonism may exacerbate seeding and spreading of tauopathy [19].
The original article has been corrected.
Reference
Gandy S, Ehrlich ME. miR155, TREM2, INPP5D: Disease stage and cell-type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer’s amyloidopathy. J Neuroinflammation. 2023;20:214. https://doi.org/10.1186/s12974-023-02895-7.
Author information
Authors and Affiliations
Corresponding authors
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Gandy, S., Ehrlich, M.E. Correction: miR155, TREM2, INPP5D: Disease stage and cell-type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer’s amyloidopathy. J Neuroinflammation 20, 288 (2023). https://doi.org/10.1186/s12974-023-02954-z
Published:
DOI: https://doi.org/10.1186/s12974-023-02954-z