Table 1 Participant clinical information and demographics

Age (years)

54.4 ± 7.0

55.9 ± 10.0

54.2 ± 10.7

56.1 ± 9.1

56.2 ± 12.3

0.902 ^a

Sex (male/female)

22/15

10/5

24/12

12/13

6/5

0.632 ^b

Education (years)

7.5 ± 3.2

7.1 ± 4.8

7.3 ± 3.8

6.4 ± 4.0

6.8 ± 4.8

0.702 ^c

Site of onset (spinal/bulbar)

-

13/2

31/5

22/3

9/2

Diagnosis (possible/probable laboratory-supported/probable/definite)

-

7/3/2/3

7/2/21/6

3/1/12/9

3/0/5/3

ASLFRS-R score

-

43.9 ± 2.1

41.4 ± 2.6

35.0 ± 6.8 ^{*, #}

33.0 ± 6.0 ^{*, #}

 < 0.001 ^c

Disease duration (months)

-

14.7 ± 12.0

12.5 ± 7.8

14.4 ± 9.2

19.5 ± 15.1

0.562 ^c

Disease progression rate

-

0.5 ± 0.4

0.8 ± 0.5

1.2 ± 0.8 ^*

1.5 ± 1.8

0.001 ^c