Association between thyroid dysfunction and perinatal outcomes in women with gestational hypertension: a retrospective study

Table 3 Logistic regression results for the associations between gestational hypertension disease, thyroid dysfunction and neonatal outcomes (preterm birth and low birth weight)

Characteristics	preterm birth		low birth weight
Characteristics	Unadjusted	Adjusted	Unadjusted	Adjusted
severity of gestational hypertension (PIH, MPE, SPE)
OR	4.914	4.360	4.119	4.023
95% CI	2.354–10.255	2.050–9.271	2.084–8.144	1.933–8.372
P Value	< 0.001	< 0.001	< 0.001	< 0.001
Onset time of gestational hypertension (EPE, LPE)
OR	0.036	0.331	0.1108	0.097
95% CI	0.011–0.112	0.009–0.110	0.041–0.283	0.033–0.282
P Value	< 0.001	< 0.001	< 0.001	< 0.001
Thyroid dysfunction
OR	2.829	3.011	2.140	2.187
95% CI	1.261–6.346	1.248–7.262	0.969–4.726	0.919–5.208
P Value	0.012	0.014	0.060	0.077
Hypothyroidism
OR	6.182	3.373	15.455	11.306
95% CI	0.993–38.478	0.411–33.893	1.625–146.973	1.040–122.889
P Value	0.051	0.242	0.017	0.046
Both FT3 and FT4 under the lower limit
OR	1.448	1.496	1.493	1.531
95% CI	1.064–1.971	1.000–2.237	1.103–2.021	1.049–2.234
P Value	0.019	0.242	0.009	0.027

Adjusted for age, gestational history, menstrual cycle, family history, and history of gestational hypertension
PIH pregnant induced hypertension; MPE mild preeclampsia; SPE severe preeclampsia; EPE early onset preeclampsia; LPE late onset preeclampsia; FT3 free triiodothyronine; FT4 free thyroxine; TSH thyrotropic hormone