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Table 1 Comparisons of the clinical data from three groups of gestational hypertension according to the severity of the disease

From: Association between thyroid dysfunction and perinatal outcomes in women with gestational hypertension: a retrospective study

Characteristics PIH (N = 30) MPE (N = 20) SPE (N = 85) PIH vs. MPE PIH vs. SPE MPE vs. SPE
Age (year, mean ± SD) 30.43 ± 4.99 31.65 ± 4.44 31.45 ± 5.23 P = 0.407 P = 0.346 P = 0.876
Gestational weeks (at delivery) (week, mean ± SD) 38.53 ± 1.53 38.16 ± 2.37 34.42 ± 4.13 P = 0.899 P < 0.001 P < 0.001
Sex of baby (male, n%) 60.9% (14/23) 50% (8/16) 54.1% (40/74) P = 0.730 P = 0.566 P = 0.768
Neonatal birth weight (g, mean ± SD) 3192.41 ± 629.84
(N = 29)
3134.21 ± 720.14
(N = 19)
2356.06 ± 787.95
(N = 71)
P = 0.791 P < 0.001 P < 0.001
Hematocrit (L/L, mean ± SD) 0.38 ± 0.03 0.37 ± 0.02 0.37 ± 0.04 P = 0.853 P = 0.328 P = 0.534
Hemoglobin (g/L, mean ± SD) 123.40 ± 9.36 123.90 ± 8.43 121.63 ± 14.41 P = 0.892 P = 0.514 P = 0.474
Platelet (10^9/L, mean ± SD) 220.53 ± 40.22 204.90 ± 45.86 194.38 ± 67.10 P = 0.524 P = 0.047 P = 0.797
Fibrinogen (g/L, mean ± SD) 4.06 ± 0.74 3.93 ± 0.63 3.73 ± 0.81 P = 0.575 P = 0.052 P = 0.301
D-Dimer (mg/L, medians and interquartile ranges) 1.67 (1.16–2.82) 1.76 (1.07–2.97) 1.84 (1.20–2.41) P = 0.823 P = 0.607 P = 0.877
Brain natriuretic peptide (pg/mL, medians and interquartile ranges) 26.50 (17.25–65.50) 40 (21–90) 84.5 (34.75–231.25) P = 0.265 P = 0.002 P = 0.075
FT3 (pg/mL, medians and interquartile ranges) 2.54 (2.24–2.69) 2.65 (2.52–2.89) 2.49 (2.26–2.70) P = 0.040 P = 0.767 P = 0.014
FT4 (ng/dL, medians and interquartile ranges) 0.98 (0.90–1.06) 0.98 (0.86–1.06) 0.93 (0.85–1.06) P = 0.992 P = 0.286 P = 0.311
TSH (mIU/L, medians and interquartile ranges) 2.32 (1.79–3.26) 2.09 (1.65–2.96) 2.58 (1.76–3.74) P = 0.342 P = 0.881 P = 0.361
Triglyceride (mmol/L, medians and interquartile ranges) 3.56 (2.78–5.93) 4.15 (2.83–4.80) 3.98 (2.85–4.94) P = 1.000 P = 0.974 P = 0.947
Total cholesterol (mmol/L, mean ± SD) 6.23 ± 1.06 5.25 ± 1.69 6.28 ± 1.75 P = 0.150 P = 0.998 P = 0.121
Low density lipoprotein (mmol/L, mean ± SD) 2.92 ± 0.93 2.15 ± 1.08 2.72 ± 1.39 P = 0.064 P = 0.490 P = 0.114
High density lipoprotein (mmol/L, mean ± SD) 1.95 ± 0.38 1.59 ± 0.73 1.76 ± 0.80 P = 0.126 P = 0.241 P = 0.408
Rate of preterm birth (n%) 7.1% (2/28) 15.8% (3/19) 58.6% (41/70) P = 0.644 P < 0.001 P = 0.001
Rate of abortion (n%) 0 0 1.3% (1/75) NS NS NS
Rate of induced labor (n%) 0 0 2.7% (2/75) NS NS NS
Rate of fetal death (n%) 0 0 2.7% (2/75) NS NS NS
Thyroid dysfunction (n%) 60% (18/30) 40% (8/20) 70.6% (60/85) P = 0.166 P = 0.286 P = 0.010
Hypothyroidism (n%) 0 0 9.4% (8/85) NS NS NS
Subclinical hypothyroidism (n%) 20% (6/30) 15% (3/20) 11.8% (10/85) P = 0.748 P = 0.622 P = 0.988
FT3 under the lower limit (n%) 6.7% (2/30) 0 8.2% (7/85) NS P = 0.847 NS
FT4 under the lower limit (n%) 16.7% (5/30) 20% (4/20) 22.4% (19/85) P = 1.000 P = 0.324 P = 0.330
FT3 and FT4 both under the lower limit (n%) 6.7% (2/30) 5% (1/20) 9.4% (8/85) P = 1.000 P = 0.709 P = 0.517
Hashimoto thyroiditis (n%) 13.3% (4/30) 10% (2/20) 5.9% (5/85) P = 0.66 P = 0.69 P = 1
hyperthyroidism (n%) 0 0 3.5% (3/85) NS NS NS
  1. A nominal 2-sided probability value < 0.05 was considered to indicate statistical significance, and adjustments were made for multiple comparisons in chi-square test and Kruskal Wallis Test (Padjust < 0.017)
  2. PIH pregnant induced hypertension; MPE mild preeclampsia; SPE severe preeclampsia; FT3 free triiodothyronine; FT4 free thyroxine; TSH thyrotropic hormone