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The role of collagenase in emphysema

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Abstract

The extracellular matrix is essential for the integrity of the lung and when disrupted can lead to the architectural changes seen in emphysema. The etiology of emphysema is believed to be due to an imbalance in the proteases and antiproteases within the lung. Studies have focused on elastolytic enzymes as the primary agents in disease pathogenesis, however, recent data suggest that collagenases may also be involved in the destruction of lung tissue in emphysema. It is hoped that this expanded understanding of the pathophysiology of emphysema will lead to improved therapy in the treatment of the disease.

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Abbreviations

α1-AT:

alpha-1-antitrypsin

COPD:

chronic obstructive pulmonary disease

ECM:

extracellular matrix

MMP:

matrix metalloproteinase

MMP-1:

collagenase

MMP-12:

metalloelastase

MT-MMP:

membrane type matrix metalloproteinase.

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Acknowledgements

We thank K Chada, A Marks and R Cole for critical reading of the manuscript and N Kolesnikova for assistance in the preparation of Figure 1. This work is supported by a National Institutes for Health RO1 grant AG16994-0 (J D'Armiento). J D'Armiento is a recipient of a Burroughs Wellcome Fund Career Award in the Biomedical Sciences.

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  1. Department of Medicine, Columbia University College of Physicians and Surgeons, 630 168th Street, P&S 9-449, New York, New York, USA

    Robert Foronjy & Jeanine D'Armiento

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  1. Robert Foronjy
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  2. Jeanine D'Armiento
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Correspondence to Jeanine D'Armiento.

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Foronjy, R., D'Armiento, J. The role of collagenase in emphysema. Respir Res 2, 348 (2001). https://doi.org/10.1186/rr85

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