Secondary brain ischaemia (SBI) usually develops after aneurysmal subarachnoid haemorrhage (SAH) and severe traumatic brain injury (TBI). The current management strategies are based on intracranial pressure-targeted therapy (ICP-targeted) with cerebral microdialysis monitoring (modified Lund concept) or cerebral perfusion pressure-targeted therapy (CPP-targeted) [1–3]. We present a randomised controlled study to compare the two management strategies.
Sixty comatose operated patients with SBI following aneurysmal SAH and severe TBI were randomized into ICP-targeted therapy with cerebral microdialysis monitoring and CPP-targeted therapy groups. Mortality rates in both groups were calculated and biochemical signs of cerebral ischaemia were analysed using cerebral microdialysis. Outcome for cerebral microdialysis was measured as poor outcome (Glasgow Outcome Scale score 1, 2 and 3) or good outcome (Glasgow Outcome Scale score 4 and 5).
Patients treated by ICP-targeted therapy with cerebral microdialysis monitoring had a significantly lower mortality rate compared with those treated by CPP-targeted therapy (P = 0.03). Patients undergoing cerebral microdialysis with poor outcome had lower mean values of glucose and higher mean values of glycerol and lactate/pyruvate ratio as compared with those with good outcome (glucose: P = 0.003; glycerol: P = 0.02; lactate/pyruvate ratio: P = 0.01). There was no difference in the outcome between aneurysmal SAH and severe TBI in the two groups.
The ICP-targeted therapy based on modified Lund concept showed better results compared with CPP-targeted therapy in the treatment of comatose patients sustaining SBI after aneurysmal SAH and severe TBI.
Belli A, Sen J, Petzold A, et al.: Metabolic failure precedes intracranial pressure rises in traumatic brain injury: a microdialysis study. Acta Neurochir 2008, 150: 461-469. 10.1007/s00701-008-1580-3
Grände PO: The 'Lund Concept' for the treatment of severe head trauma - physiological principles and clinical application. Intensive Care Med 2006, 32: 1475-1484.
Nordström CH: The 'Lund concept': what it is and what it isn't [correspondence]. Intensive Care Med 2007, 33: 558.
Rights and permissions
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Hamdan, M., Dizdarevic, K. Modified Lund concept versus cerebral perfusion pressure-targeted therapy: a randomized controlled study in patients with secondary brain ischaemia. Crit Care 15 (Suppl 1), P342 (2011). https://doi.org/10.1186/cc9762
- Traumatic Brain Injury
- Management Strategy
- Cerebral Ischaemia
- Subarachnoid Haemorrhage
- Therapy Group