Introduction
Pulmonary dysfunction after cardiac arrest is a common phenomenon. Evidence appears to support the usefulness of quanti-tative assessment of pulmonary dysfunction using extravascular lung water (EVLW) and the pulmonary vascular permeability index (PVPI). We hypothesized that the duration of cardiac arrest (CPA TIME) would impact the pulmonary dysfunction in patients with postcardiac arrest syndrome. The aim of the present study was to investigate the lung dysfunction quantitatively using EVLW and PVPI in successfully resuscitated patients after cardiac arrest (CPA).
Methods
This was a prospective observational study of 106 (59 male, 47 female) postcardiac arrest syndrome patients. Eligible patients included all who were in CPA on arrival at the hospital and experienced effective resuscitation resulting in resumption of spontaneous circulation. All patients were resuscitated per therapeutic protocol in our hospital. The CPA TIME from the scene was recorded. The patients were divided into two groups by the cause of CPA; cardiogenic (CG) or noncardiogenic (NCG). Thermodilutional EVLW and PVPI measurements were performed using the PiCCO monitoring system (Pulsion Medical Systems, Munich, Germany) as soon as the patients were admitted to the ICU.
Results
A moderate positive correlation was documented between the CPA TIME, EVLW (r = 0.36, P < 0.001) and PVPI (r = 0.43, P < 0.001) in all 106 patients. In the CG group, we found a very close positive correlation between the CPA TIME, EVLW (r = 0.52, P < 0.001) and PVPI (r = 0.75; P < 0.001). No correlations were documented between the CPA TIME, EVLW (r = 0.25, P = 0.05) and PVPI (r = 0.24, P = 0.06) in the NCG group.
Conclusions
The duration of cardiac arrest impacts on the increase in the EVLW and PVPI, especially in patients with CG postcardiac arrest syndrome.
Acknowledgements
Clinical trial registration UMIN-CTR: UMIN00000 3224.
Author information
Authors and Affiliations
Rights and permissions
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Tagami, T., Tosa, R., Omura, M. et al. Impact of cardiac arrest duration on extravascular lung water and pulmonary vascular permeability in patients with postcardiac arrest syndrome: a prospective observational study. Crit Care 15 (Suppl 1), P140 (2011). https://doi.org/10.1186/cc9560
Published:
DOI: https://doi.org/10.1186/cc9560