Abstract
The oxygen supply to the joint cartilage depends on the oxygen transport from the capsular arteries to the capillaries, the oxygen diffusion across the synovial membrane and the oxygen transport through the synovia. In osteoarthritis the resistance to transport across all 3 barriers may be increased because of the joint effusion, the elevated intraarticular pressure and the inflammatory changes of the synovial membrane.
In the present study we describe a method to determine 2 important parameters affecting the oxygen transport through the synovial membrane: the oxygen consumption and diffusion capacity of the membrane. The principle of the method is to perfuse the joint cavity of the knee by saline saturated with air and to record the relationship between the oxygen partial pressure in the outflowing perfusate and the perfusion rate.
The values found for the diffusion capacity and oxygen consumption were 0.039 ± 0.013 μl O2/min/Torr and 0.93 ± 0.90 μl O2/min (mean ± s).
Sammendrag
Iltforsyningen til den hyaline ledbrusk er afhængig af transport fra kapselarterierne til kapillærerne, diffusion over synovialmembranen, samt transport gennem synovi. Osteoartritis og andre effusive ledlidelser kan hypotetisk medføre en nedsat ilt overførsel over alle tre barrierer. I nærværende arbejde redegøres for en ny metode baseret på ledperfusion til bestemmelse af synovialmembranens metabolisme og diffusionskapacitet in vivo.
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References
Ahlqvist, J.: A hypothesis on the pathogenesis of rheumatoid and other non-specific synovitides. Medical Hypotheses 1984, 13, 257–302.
Bartels, H. & H. Harms: Sauerstoffdissoziationskurven des Blutes von Säugetieren. (Oxygen dissociation curves in mammal blood). Pflügers Arch. 1959, 268, 334–365.
Gill, P. E. & W. Murray: Algorithms for the solution of the non-linear least squares problem. SIAM Journal on Numerical Analysis 1978, 15, 977–992.
Goetzl, E. J., K. H. Falchuk, L. S. Zeiger, A. L. Sullivan, C. L. Hebert, J. P. Adams & L. Decker: A physiological Approach to the Assessment of Disease Activity in Rheumatoid Arthritis. J. clin. Invest. 1971, 50, 1167–1179.
Grønlund, J.: Errors due to data reduction in single-breath method for measurement of pulmonary blood flow. J. appl. Physiol. 1982, 52, 104–108.
Grønlund, J. & P. Christensen: Error due to dead-space admixture in single-breath method for estimation of pulmonary blood flow. J. appl. Physiol. 1985, 58, 1034–1039.
Jayson, M. I. V. & A. St. J. Dixon: Intra-articular pressure in rheumatoid arthritis of the knee. Pressure changes during passive joint distension. Ann. Rheum. Dis. 1970, 29, 261–265.
Lane, J. M., C. T. Brighton & B. J. Menkowitz: Anaerobic and aerobic metabolism in articular cartilage. J. Rheumatol. 1977, 4, 334–342.
Lucht, U., C. Bünger, B. Krebs, J. Hjermind & J. Bülow: Blood flow in the juvenile hip in relation to changes of the intraarticular pressure. Acta orthop. scand. 1983, 54, 182–187.
Lundsgaard, J. S., B. Jensen & J. Grønlund: Fast-responding flow-independent blood gas catheter for oxygen measurement. J. appl. Physiol. 1980, 48, 376–381.
Phelps, P., A. D. Steele & D. J. McCarty: Significance of xenon-133 clearance rate from canine and human joints. Arth. & Rheum. 1972, 15, 360–370.
Siggaard-Andersen, O.: The Acid-Base Status of the Blood. 4th ed. Munksgaard, Copenhagen 1974, p. 32.
Svalastoga, E. & L Reimann: Experimental osteoarthritis in the rabbit. I. Histological changes in the synovial membrane. Acta vet. scand. 1985, 26, 313–325.
Weathersby, P. K. & L. D. Homer: Solubility of inert gases in biological fluids and tissues: a review. Undersea Biomed. Res. 1980, 7, 277–296.
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Svalastoga, E., Grønlund, J. Experimental Osteoarthritis in the Rabbit. Acta Vet Scand 26, 326–339 (1985). https://doi.org/10.1186/BF03546533
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DOI: https://doi.org/10.1186/BF03546533