Cutaneous squamous cell carcinoma (SCC) is a malignant neoplasm of the keratinizing epidermal cells and it accounts for 20% of all cases of nonmelanoma skin cancer. Important etiologic factors to the development of SCC are host characteristics, such as male gender, age, skin pigmentation, and environmental elements, the most important being long-time exposure to sunlight. Other predisposing factors include ionizing radiation, exposure to UV light, exposure to chemical carcinogens and chronic immunosuppression which is not HIV-associated. Though cutaneous SCC had been reported in several regions of the body, we are reporting two cases of cutaneous squamous cell carcinoma in the penile shaft and left gluteal region.