Serum estradiol/progesterone ratio on day of embryo transfer may predict reproductive outcome following controlled ovarian hyperstimulation and in vitro fertilization
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To determine whether estradiol-to-progesterone (E2/P) ratios at the time of embryo transfer (ET) have an effect on implantation and pregnancy in IVF cycles.
239 women consecutively treated by IVF or ICSI were retrospectively analyzed and early luteal serum E2 and P were measured on the day of ET. Transfer occurred after a variable in vitro culture period ranging from 4–7 days after ovulation induction (OI). Following ET, serum E2/P ratios were calculated for clinical pregnancies, preclinical abortions and non-coneption cycles.
Receiver-operator curve analysis demonstrated that the E2/P ratio could differentiate between clinical pregnancies and non-pregnant cycles (area under the curve on OI +4 days = 0.70; 95% CI = 0.60–0.80; p = 0.003, on OI +5 days = 0.76; 95% CI = 0.64–0.88; p = 0.001, OI +7 days = 0.85; 95% CI = 0.75–0.96; p < 0.0001).
These retrospective data may hold prognostic value regarding endometrial receptivity as reflected by E2/P measurements and may help improve IVF treatment outcome. Further prospective studies should be undertaken to confirm these obersveration.
- 3.Albano C, Grimbizis G, Smitz J, Riethmuller-Winzen H, Reissmann T, Van Steirteghem A, Devroey P: The luteal phase of nonsupplemented cycles after ovarian superovulation with human menopausal gonadotrophin-realising hormone antagonist Cetrorelix. Fertil Steril. 1998, 70: 357-359. 10.1016/S0015-0282(98)00135-6.CrossRefPubMedGoogle Scholar
- 6.Ng Hung Yu E, Shu Biu Yeung W, Yee Lan Lau E, Wai Ki So W, Ho Chung P: A rapid decline in serum oestradiol concentrations around the mid-luteal phase had no adverse effect on outcome in 763 assisted reproduction cycles. Hum Reprod. 2000, 15: 1903-1908. 10.1093/humrep/15.9.1903.CrossRefGoogle Scholar
- 9.Weitlauf HM: Biology of implantation. The Physiology of Reproduction. 1994, New York: Raven Press, 233-277.Google Scholar
- 18.Macklon NS, Fauser BC: Impact of ovarian hyperstimulation on the luteal phase. J Reprod Fertil. 2000, 101-108. Suppl 55Google Scholar
- 21.Beckers NG, Macklon NS, Eijkemans MJ, Ludwig M, Felberbaum RE, Diedrich K, Bustion S, Loumaye E, Fauser BC: Nonsupplemented luteal phase characteristics after the administration of recombinant human chorionic gonadotropin, recombinant luteinizing hormone, or gonadotropin-releasing hormone (GnRH) agonist to induce final oocyte maturation in in vitro fertilization patients after ovarian stimulation with recombinant follicle-stimulating hormone and GnRH antagonist co treatment. J Clin Endocrinol Metab. 2003, 88: 4186-4192. 10.1210/jc.2002-021953.CrossRefPubMedGoogle Scholar
- 22.Papanikolaou EG, Bourgain C, Kolibianakis E, Tournaye H, Devroey P: Steroid recepter expression in late follicular phase endometrium in GnRH antagonist IVF cycles is already transformation in the absence of secretory changes. Hum Reprod. 2005, 20: 1541-1547. 10.1093/humrep/deh793.CrossRefPubMedGoogle Scholar
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