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Retrovirology

, 3:S51 | Cite as

Entry inhibitors as topical microbicides to prevent HIV-1 sexual transmission

  • John P Moore
Open Access
Oral presentation
  • 779 Downloads

Keywords

Peptide Infectious Disease Cancer Research Small Molecule Specific Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Specific inhibitors of HIV-1 attachment, fusion and entry are one approach to a topical microbicide. We have been evaluating several such compounds (small molecules and peptides) targeting several different stages of the fusion process, for their abilities to prevent experimental infection of rhesus macaques with various SHIVs, after vaginal challenge. These results will be presented and discussed, in the context of developing a practical product for use in women and men.

Copyright information

© Moore; licensee BioMed Central Ltd. 2006

This article is published under license to BioMed Central Ltd.

Authors and Affiliations

  • John P Moore
    • 1
  1. 1.Professor of Microbiology and ImmunologyWeill Cornell Medical CollegeNew YorkUSA

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