Predictors of Right Ventricular Ejection Fraction in Patients with Nonischemic Cardiomyopathy
KeywordsIndependent Predictor Leave Ventricular Ejection Fraction Mitral Regurgitation Ventricular Dysfunction Male Gender
Right ventricular dysfunction is a known predictor of mortality in patients with nonischemic cardiomyopathy (NICM), however predictors of right ventricular ejection fraction (RVEF) in this patient population are poorly understood. We sought to identify independent predictors of RVEF, measured using cardiac MRI, in patients with NICM.
We retrospectively evaluated 140 consecutive patients with NICM who underwent delayed hyperenhancement cardiac MRI between 2002 and 2009. A Cox proportional hazards model was used to evaluate the association between RVEF and the composite outcome of death, left ventricular assist device implantation, or heart transplantation. Predictors of RVEF were evaluated using a multivariable linear regression model.
Right ventricular dysfunction has been shown to predict poor outcomes in patients with NICM, but predictors of RVEF in this cohort are not well defined. We found male gender, lower LVEF, higher LV myocardial fibrosis, and the presence of RBBB were independent predictors of lower RVEF. While MR severity was associated with RVEF on univariate analysis, this relationship was not significant independent of LVEF.
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