Background
Left ventricular non-compaction (LVNC) cardiomyopathy is characterized by a thin, compacted epimyocardial and a thick non-compacted, trabeculated endomyocardial layer. High-resolution cardiac magnetic resonance imaging (CMR) has been clinically successfully used to establish a Non-compact-to-compact- (NCTC) ratio of 2.3 in a 4-chamber view which is regarded pathological. Clinically, in patients with dilated cardiomyopathy (DCMP) and noticeably even in volunteers with physiological myocardial trabecularisation, up to 28% of verifiably healthy participants demonstrated the NCTC-ratio ≥ 2.3 so that there is a clinical need for a better distinction between patients with LVNC, DCMP and healthy subjects.
We hypothesized that MRI is able to clearly distinguish LVNC from DCMP and healthy volunteers by a novel combined MRI and statistical approach of morphological and functional parameters.
Methods
31 LVNC patients, defined by an MRI NCTC-ratio >2.3 (in a 4-chamber view plus one additional parameter (fulfilment of echo-criteria, histology, genetic proof, invasive X-ray), 13 patients with histologically proven inflammatory DCMP as well as 117 male/female healthy volunteers were studied employing a vector-ECG gated multi-slice 2-, 3-, 4-chamber and short axis (SA) standard cine SSFP-sequence covering the entire left ventricle. Functional parameters like end-diastolic, end-systolic volumes and ejection fraction were generated via SA SSFP slices as usual. Compacted and non-compacted thicknesses were defined in 2-,3-,4-chamber views as illustrated in Figure 1A-C, as previously published. With a stepwise discriminant analysis, statistically significant morphological and functional predictors for clear distinction of LVNC, DCMP and physiological trabeculation were found and were successfully cross-validated with a jackknife procedure.
![figure 1](http://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2F1532-429X-14-S1-M7/MediaObjects/12968_2012_Article_2046_Fig1_HTML.jpg)
Figure 1
Results
Six predictors were determined to improve correct prediction: ejection fraction, compact thicknesses in 2- and 4-chamber views, NCTC-ratios in 2-and 4-chamber views and the non-compacted thickness in 3-chamber views. The combination of these six predictors led to a correct categorisation in 93% of cases which can be seen from Figure 2.
![figure 2](http://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2F1532-429X-14-S1-M7/MediaObjects/12968_2012_Article_2046_Fig2_HTML.jpg)
Figure 2
Conclusions
The correct identification of patients with cardiomyopathies and their clear distinction from healthy volunteers is clinically and therapeutically as well as socio-economically of paramount importance. By simple combination of values for ejection fraction, compact thicknesses in 2- and 4-chamber views, NCTC-ratios in 2-and 4-chamber views and the non-compacted thickness in 3-chamber views, we present a method that sufficiently distincts LVNC and DCMP patients from healthy volunteers. Prospective clinical trials have to be conducted to validate this approach in the future.
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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Burger, A., Lehrke, S., Voss, A. et al. MRI morphological and functional method for clear distinction of patients with left ventricular non-compaction, inflammatory dilated cardiomyopathy and physiological myocardial trabeculation. J Cardiovasc Magn Reson 14 (Suppl 1), M7 (2012). https://doi.org/10.1186/1532-429X-14-S1-M7
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DOI: https://doi.org/10.1186/1532-429X-14-S1-M7