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Table 1 Clinical and Conventional Imaging Characteristics

From: Impact of diastolic dysfunction severity on global left ventricular volumetric filling - assessment by automated segmentation of routine cine cardiovascular magnetic resonance

  Normal
Diastolic
Filling
(n = 40)
Grade 1
Diastolic
Dysfunction
(n = 21)
Grade 2
Diastolic
Dysfunction
(n = 45)
Grade 3
Diastolic
Dysfunction
(n = 9)
P
CLINICAL      
Age (year) 50 ± 10 62 ± 7 61 ± 14 52 ± 12 < 0.001
Male gender 90% (36) 86% (18) 71% (32) 100% (9) 0.05*
Atherosclerosis Risk Factors      
   Hypertension 28% (11) 43% (9) 62% (28) 22% (2) 0.007
   Hyperlipidemia 33% (13) 38% (8) 60% (27) 56% (5) 0.06*
   Diabetes Mellitus 18% (7) 10% (2) 27% (12) 22% (2) 0.41
   Tobacco Use 40% (16) 24% (5) 40% (18) 33% (3) 0.58
   Family History 38% (15) 24% (5) 18% (8) 22% (3) 0.22
Coronary Artery Disease History      
   Prior Myocardial Infarction 3% (1) 14% (3) 4% (2) 0% (-) 0.20
   Prior Coronary Revascularization 5% (2) 19% (4) 11% (5) 11% (1) 0.40
Cardiovascular Medications      
   Beta-blocker 100% (40) 100% (21) 98% (44) 100% (9) 0.67
   ACE Inhibitor/ARB 73% (29) 62% (13) 82% (37) 67% (6) 0.33
   HMG-CoA Reductase Inhibitor 98% (39) 100% (21) 93% (42) 100% (9) .47
   Aspirin 100% (40) 100% (21) 100% (45) 100% (9) -
   Thienopyridines 98% (39) 95% (20) 93% (42) 100% (9) 0.72
Infarct Related Artery      
   Left Anterior Descending 58% (23) 62% (13) 64% (29) 78% (7) 0.71
   Right Coronary 33% (13) 24% (5) 29% (13) 11% (1) 0.60
   Left Circumflex 10% (4) 14% (3) 7% (3) 0% (-) 0.57
Revascularization Strategy      
   Primary Percutaneous Intervention 73% (29) 62% (13) 67% (30) 56% (5) 0.72
   Primary Thrombolysis 25% (10) 43% (9) 27% (12) 44% (4) 0.36
ECHOCARDIOGRAPHY      
LV Morphology/Systolic Function      
   Ejection Fraction (%) 50 ± 8 50 ± 11 48 ± 12 32 ± 15 < 0.001
   Wall Motion Score 13 ± 10 14 ± 11 15 ± 12 33 ± 14 < 0.001
   End-diastolic diameter (cm) 5.6 ± 0.5 5.8 ± 0.5 5.6 ± 0.5 6.2 ± 0.4 0.01
   End-systolic diameter (cm) 4.1 ± 0.5 4.3 ± 0.6 4.2 ± 0.6 5.1 ± 0.7 < 0.001
   Relative Wall Thickness (g/m2) .030 ± 0.04 0.29 ± 0.03 0.31 ± 0.04 0.25 ± 0.04 0.005
   Myocardial Mass (g/m2) 92 ± 15 97 ± 14 96 ± 15 92 ± 16 0.56
Left Atrial Diameter (cm) 3.8 ± 0.5 3.9 ± 0.6 4.0 ± 0.5 4.4 ± 0.4 0.005
CARDIOVASCULAR MAGNETIC RESONANCE      
LV Morphology/Systolic Function      
   Ejection fraction (%) 57 ± 8 55 ± 9 54 ± 12 41 ± 10 0.001
   Wall motion Score 11 ± 9 14 ± 7 15 ± 10 29 ± 12 < 0.001
   End-diastolic volume (ml) 151 ± 34 141 ± 32 149 ± 45 220 ± 49 < 0.001
   End-systolic volume (ml) 66 ± 24 66 ± 26 70 ± 36 133 ± 49 < 0.001
   Myocardial Mass (g/m2) 67 ± 12 71 ± 14 72 ± 17 79 ± 20 0.15
LV Infarct Size (% myocardium) 14 ± 9 16 ± 9 17 ± 10 27 ± 8 0.005
Left Atrial Volume (ml) 80 ± 19 77 ± 20 95 ± 31 115 ± 25 < 0.001
  1. Boldface type indicates p value < 0.05
  2. * indicates p < 0.1