Target-site penetration was evaluated in autopsy samples (lung, brain, kidneys, liver, spleen, heart) of two patients who had died during treatment with VOR. Patient 1 had obtained a single-dose of VOR (200 mg), the interval between the last administration and death was 36 hours. Patient 2 was on VOR therapy under steady-state (day 10, cumulative dose 3,800 mg). He died 12 hours after the last VOR infusion. Tissue samples were obtained during routine autopsy, homogenized, purified and quantified by HPLC.