Mechanical ventilation patterns and trends over 20 years in an Israeli hospital system: policy ramifications
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Mechanical ventilation is a life supporting modality increasingly utilized when caring for severely ill patients. Its increasing use has extended the survival of the critically ill leading to increasing healthcare expenditures. We examined changes in the hospital-wide use of mechanical ventilation over 20 years (1997–2016) in two Israeli hospitals to determine whether there were specific patterns (e.g. seasonality, weekday vs. weekend) and trends (e.g. increases or decreases) among various hospital departments and units.
Retrospective analysis of prospectively collected data on all mechanically ventilated patients over 20-years in a two-hospital Israeli medical system was performed. Data were collected for each hospital unit caring for ventilated patients. Time-series analysis examined short and long-term trends, seasonality and intra-week variation.
Over two decades overall ventilator-days increased from 11,164 (31 patients/day) in 1997 to 24,317 (67 patients/day) in 2016 mainly due to more patients ventilated on internal medicine wards (1997: 4 patients/day; 2016: 24 patients/day). The increases in other hospital areas did not approach the magnitude of the internal medicine wards increases. Ventilation on wards reflected the insufficient number of ICU beds in Israel. A detailed snapshot over 4 months of patients ventilated on internal medicine wards (n = 745) showed that they tended to be elderly (median age 75 years) and that 24% were ventilated for more than a week. Hospital-wide ventilation patterns were the weighted sum of the various individual patient units with the most noticeable pattern being peak winter prevalence on the internal medical wards and in the emergency department. This seasonality is not surprising, given the greater incidence of respiratory ailments in winter.
Increased mechanical ventilation plus seasonality have budgetary, operational and staffing consequences for individual hospitals and the entire healthcare system. The Israeli healthcare leadership needs to plan and support expanding, equipping and staffing acute and chronic care units that are staffed by providers trained to care for such complex patients.
KeywordsMechanical ventilation Seasonality Internal medicine Intensive care unit Respiratory care Intensive care unit
Mechanical ventilation is a life supporting modality often employed in the care of severely ill patients. The increasing use of mechanical ventilation parallels greater hospitalization in intensive care units and is attributed to an aging population, the advent of sophisticated surgical procedures, more aggressive medical, neurological and oncological treatments and improved treatment of critical illness [1, 2, 3]. Recent epidemiological research in the US revealed that about 310 persons per 100,000 adult population undergo invasive ventilation for nonsurgical indications . This situation has led to increased healthcare expenditures [4, 5]. In the United States daily intensive care unit (ICU) costs are three to five times the costs of regular ward care [6, 7]. A portion of these higher costs is attributable to the equipment, supply and personnel expenditures required to care for ventilated patients . However, mechanically ventilated patients are not only found in ICUs but also in intermediate care units, ventilator weaning units and patient wards [9, 10, 11]. In Israel, many seriously ill patients are mechanically ventilated in internal medicine wards due to a shortage of ICU beds [10, 12, 13, 14].
In an era of increasing awareness of healthcare costs it is important to be cognizant of the patterns of in-patient mechanical ventilator utilization not only within ICUs but also in other areas of the hospital. This study explores the prevalence patterns of mechanical ventilation using a dataset collected over a 20-year period (1997–2016) in a two-hospital Israeli medical system that includes a tertiary care medical center and a community hospital. We examined hospital-wide ventilator use and patterns of ventilation in various areas of the hospital ranging from the surgical ICU to the internal medicine floors. The aim was to determine patterns of ventilator use (e.g. seasonality, weekday vs. weekend).. Another goal was to provide useful information to healthcare leaders about budgeting, staffing, equipment purchasing and materials management. Among the hypotheses tested was that over 20 years there have been substantial increases in the prevalence of mechanical ventilation. Another hypothesis examined was that although the overall pattern of mechanical ventilator utilization is seasonal, this pattern is due to internal medicine and not surgical activity.
Materials and methods
Data were assembled from an administrative database of the Hadassah-Hebrew University Medical Center. This two-hospital system includes a 900-bed tertiary care university hospital which serves as the major referral center and regional level 1 trauma center for a metropolitan area of over 1 million inhabitants. The other hospital is a 300-bed community hospital. The dataset includes the routine daily ventilator (both invasive and non-invasive) census collected at 8:00 AM over a 20-year period (1997 through 2016) by the Respiratory Care Service. The data were collected separately for each hospital unit that cared for ventilated patients. Patients not accommodated in medical intensive care units (MICU) are routinely ventilated on the internal medicine floors. However, surgical and pediatric patients are rarely ventilated outside an ICU.
Additionally, a detailed “snapshot” using data collected by the Respiratory Care Service of the age and duration-of-ventilation of individual patients on the internal medicine wards over 4 months in 2015 was analyzed.
Data were entered onto Excel® spreadsheets (Microsoft Inc., Redmont, WA) where descriptive statistical analysis was performed. Further analysis was performed with Systat 12 (Systat, San Jose, CA) Continuous variables with normal distributions are reported as mean ± standard deviations, those with non-normal distributions are reported as medians. Inter and intra-group comparisons were performed with analysis of variance and Tukey post-hoc tests. Best-fit regression analysis examined the association of ventilator-days patterns with time and was also used to compare ventilation patterns between various units. Statistical significance was inferred at p < 0.05.
Mechanical ventilator prevalence data from each hospital and their individual units, including general (GICU), medical (MICU), pediatric, neonatal, cardiothoracic surgery (CSICU) intensive care units and internal medicine wards were subjected to time-series and frequency domain analysis. The latter used Fourier transformation, while the former used time-series analysis to examine the internal structure of each data-file seeking autocorrelation, short and long-term trends, seasonality and intra-week variation. Winter was defined as December to March.
This study was approved by the Institutional Review Board. Informed Consent was waived due to the retrospective nature of the study.
There were increases in overall ventilator-days at the community hospital (1997: 9 patients/day; 2016: 14 patients/day) that plateaued after 10 years (best fit regression equation: y = 2E-10 × 6 - 1E-07 × 5 + 4E-05 × 4–0.0059 × 3 + 0.4421 × 2–12.653x + 330.97, r2 = 0.41), likely because of a saturation phenomenon due to lack of increases in internal medicine ward beds during the study period (two wards, total 72 beds) (Figs. 1b and 2b).
The increase in ventilator-days in the university hospital was mainly influenced by substantial ventilator-day increases in the internal medicine wards (r2 = 0.88, p < 0.0001) and to a much lesser degree by the GICU (r2 = 0.48, p < 0.001) and MICU (r2 = 0.40, p < 0.001) (Fig. 3). Other units showed smaller increases (pediatric intensive care units) or even small reductions (CSICU) in ventilator activity (Fig. 1). The frequency domain of the internal medicine wards had a major peak at a single frequency, while the pattern in the SICU was more heterogeneous.
This study points out two important aspects of contemporary respiratory care: Increasing use of mechanical ventilation and various unit-specific patterns of mechanical ventilation. The major finding was that over the past two decades there was more than a doubling of ventilator-days in a two-hospital system located in Jerusalem mainly due to more patients ventilated in internal medicine wards. Although there were increases in other hospital areas they did not approach the magnitude of the increases seen in the internal medicine wards. These observations are consistent with those of other investigators who pointed out that the success of ICUs has vastly enhanced the ability and technology to support vital body functions, especially respiration [1, 2, 3]. As a result more and more patients are mechanically ventilated during their hospitalization with their numbers expected to rise in the future . In the early 2000’s prolonged acute mechanical ventilation (≥96 h) in the United States increased at an annualized rate of 5.5% while the population increased by only 1% . In the United States during 2005, 6,469,674 patients were hospitalized in six states with 180,326 (2.8%) receiving invasive mechanical ventilation. A total of 44.6% of the ventilated patients had at least one major co-morbidity; the most common being diabetes (13.2%) and pulmonary disease (13.2%). In-hospital mortality was 34.5% with only 30.8% of patients discharged home . In Israel there are insufficient ICU beds causing many patients, especially elderly ones, to receive mechanical ventilation on internal medicine and neurology wards. This was demonstrated by the present study where the median age of patients ventilated on internal medicine wards was 75 years.
The hospital-wide ventilation patterns were the weighted sum of the patterns of individual patient units. The most apparent pattern was a seasonal one, with the peak prevalence during the winter due to seasonal patterns on the internal medical wards. This seasonal pattern is not surprising, given the greater incidence of pneumonia, influenza and chronic obstructive pulmonary disease (COPD) exacerbations during the winter [17, 18, 19, 20]. In Wales, pneumococcal disease displayed a marked preponderance during winter . Peaks also occur at other times of the year, with peak asthma exacerbations in Canadian children occurring during early September, correlating directly with the start of the school year , although others showed peak ICU asthma admissions during winter . Therefore, on internal medicine and pediatric services seasonal variation among respiratory ailments typically occurs. We observed such a seasonal pattern in the adult emergency department, where ventilated patients often remained for extended periods while awaiting ICU or internal medicine ward beds. This situation contributes to the overload seen in Israeli emergency departments during winter .
Seasonal variation was not found in the GICU, which treated mainly surgical patients, nor in the CSICU or Neurosurgical ICU. This confirms the hypothesis that surgical ICUs do not contribute to the overall seasonality of mechanical ventilator use. This lack of seasonality can be explained by surgical illnesses, such as abdominal catastrophes and acute cardiac syndrome not being seasonal. However, trauma is often a seasonal occurrence, with peak incidence during summer [24, 25, 26]. A study of neurotrauma in Israel reported spring and summer peaks . However, lack of seasonality in GICU mechanical ventilator use might be explained by a summer decrease in elective surgery requiring postoperative ICU care offsetting the increase in trauma . The former decrease is attributable to surgeons, anesthesiologists and operating room nurses taking summer vacations thus decreasing elective surgical volume . This complex pattern was demonstrated by the multi-peaked GICU frequency domain, unlike the singular-peaked pattern seen in the medical wards. Over the 20-year study there were small increases in GICU ventilator-days, despite a 60% increase in surgical volume and a 48% increase in GICU daily occupancy (C. Weissman, personnel communication). The introduction of advanced anesthetic and surgical techniques, including minimally invasive surgery, endovascular stents and angiographic control of traumatic hemorrhage have reduced postoperative mechanical ventilation, but not ICU admission. There was a small, but significantly greater number of ventilated GICU patients on Sunday than on Wednesday morning, likely reflecting a greater weekend trauma admission rate [29, 30]. The CSICU had a within-week pattern consistent with the weekdays that elective operations were performed. There were also fewer ventilated patients during April and September/October consistent with Israeli holiday periods and reduced elective surgery. A similar reduction in elective surgery coinciding with holidays was also observed with hip and knee replacement surgery in Canada [31, 32].
Implications for hospitals
Analyzing both overall and unit-specific prevalence patterns helps plan for sufficient and adequately equipped and staffed locations for safe mechanical ventilation.
Areas with seasonal patterns, like internal medicine wards, require more nursing and respiratory care staff during the winter, while locations without seasonality require stable staffing throughout the year. This eases the burden on respiratory care departments when staff wish to take summer vacations .
Most hospital monthly supply budgets are the same throughout the year. However, in units with marked seasonal variation, budgets for respiratory care and other supplies should have a seasonal pattern to prevent shortfalls during the winter [34, 35].
Implications for the healthcare system
Ideally, hospitalized acutely ill mechanically ventilated patients should be cared for in settings, such as intensive and intermediate care units, where nurse:patient ratios are high (1:1 to 1:4) and medical and nursing staffs specially trained to care for complex respiratory problems, as well as in weaning such patients from their ventilators . Optimally, patients unable to wean from their ventilators should be directly transferred either to specialized weaning units or to outside facilities that provide chronic ventilator care for further evaluation, weaning attempts and if weaning is unsuccessful, prolonged mechanical ventilation .
Israel has insufficient ICU beds causing many patients to receive mechanical ventilation on internal medicine, geriatric and neurology wards . Izhakian and Buchs  found a 72% in-hospital mortality rate among 437 ventilated patients (median age 83 years) admitted directly from the emergency department to the medical wards of an Israeli hospital. This mortality rate was similar to reports from other Israeli medical wards. Studies from Israel, Britain and Hong Kong showed better survival of patients admitted directly to ICUs or transferred to an ICU shortly after starting mechanical ventilation, than those cared for exclusively on medicine wards [10, 13, 40, 41, 42, 43]. However, this statement must be qualified since patients admitted to the ICU often having better functional status than those admitted to the wards . In fact, some Israeli patients ventilated on medical or other wards were never presented for admission to the ICU staff.
Capital Expenditures: Purchasing mechanical ventilators and equipping wards with infrastructure (medical gases, physiologic monitors, centralized alarm systems) to support safe ventilation.
Operating Costs: More respiratory supplies plus employing added respiratory and biomedical engineering technicians tasked with maintaining mechanical ventilators.
Physicians and Nurses: Occupancy rates during winter routinely reach 105–110% of capacity in Israeli internal medicine wards, heavily burdening nurses and physicians since among the added patients, are high acuity ventilated ones . These latter patients require both higher nurse:patient ratios and nurses and physicians with enhanced skill sets. However, budgetary limitations plus a nationwide nursing shortage often do not permit adequate staff expansion. This likely retards the ability to optimally care for these seriously ill patients likely leading to extended lengths-of-stay and reduced success with weaning from mechanical ventilation. In one report such patients had a one month post-discharge mortality of 79% .
Adding ICU beds only addresses part of the problem given the many ventilated patients and greater expenses involved in building and operating ICU beds as opposed to intermediate care or ward beds.
Higher per-diem reimbursement for mechanically ventilated patients. Although, over the 20-year period per-diem reimbursement has increased due to inflation and wage increases, no special reimbursement rate for non-ICU mechanically ventilated patients has been established. This lack of differential payments for mechanically ventilated patients has resulted in a situation where hospital revenues do not increase in accord with greater patient acuity and these patients’ increased personnel and equipment needs. This is part of a broader problem in Israel’s hospital reimbursement system where there are differential payments for some surgical admissions, which are generally reimbursed as Procedure Related Groups while there are no differential payments for internal medical admissions [45, 46].
Increasing nurse staffing and improving knowledge and skills to better care for mechanically ventilated patients outside ICUs.
Introducing bachelor degree level respiratory therapists to aid in caring and weaning mechanically ventilated patients. In the United States and Canada such licensed practitioners enhance the care of respiratory patients by relieving nurses of many technical and clinical respiratory care tasks plus providing specialized expertise in liberating patients from mechanical ventilation [47, 48].
Physicians: The burden of caring for much of the increase in ventilated patients falls on internal and emergency medicine physicians, especially residents. However, often these physicians do not have specialized training in the technical and clinical aspects of mechanical ventilation [49, 50]. Also, most internal medicine residents plan to subspecialize in disciplines that do not care for such patients . Whether internal medicine residency programs should include 3–4 months of required ICU training to improve residents’ skills could be considered. Another, possibility is training more critical care medicine specialists to consult on difficult to wean ventilated patients.
Expand existing and add skilled nursing facilities capable of caring for chronically ventilated patients: In the current study, a quarter of ventilated internal medicine ward patients were ventilated for > 7 days. Many such patients are candidates for transfer to skilled nursing facilities but existing Israeli facilities are unable to meet demand resulting in chronically ventilated patients remaining in acute care hospitals for extended periods .
The ethical issues of end-of-life care, advanced directives and living wills are crucial for the Israeli healthcare system. Among the reasons for publishing the present data was to spur socio-ethical research on mechanical ventilation and other life-supporting (extending) modalities, especially among patient populations ventilated on internal medicine, geriatric and neurology wards. Yet, this is a sensitive issue in Israel with its varied populations and religious beliefs.
Strengths and limitations
This study’s major strength is that it analyzes in-patient mechanical ventilation using methods borrowed from econometrics, a discipline that specializes in exploring trends. Another strength was a dataset spanning 20 years that permitted us to examine both short and long-term trends. A limitation is that it included data from only two hospitals. However, research from other Israeli hospitals reported similar trends but over much shorter time frames [39, 37].
Detailed analysis of the long-term trends of mechanical ventilation in a two-hospital system provided insight into a major issue facing Israeli healthcare. Increased prevalence of mechanical ventilation is a marker of the increasing age and illness severity of the hospitalized population, especially the denizens of internal medicine wards. This upward trend should continue as the proportion of the population over 65 years increases from 10 to 15% by 2035 . Therefore, the healthcare leadership must plan to care for such patients, specifically, to provide financial support to adequately expand, equip and staff acute and chronic care facilities staffed by providers trained to care for such complex patients. This program should be supported by continuous data collection and statistical analysis similar to that performed in this study. Among other possible initiatives are higher per-diem hospital reimbursements for ventilated patients, training bachelor degree level respiratory therapists, improved training of nurses and house officers and establishing more dedicated weaning units in acute care hospitals and/or skilled nursing facilities. Moreover, the subject of advanced directives, living wills and end-of-life care should be addressed .
The authors thank the staff of the Respiratory Care Service for collecting the daily ventilator census.
Availability of data and materials
All data generated or analysed during this study are included in this published article.
RYZ – study design, interpreted data. Reviewed and critiqued manuscript; CW – study design, analyzed data, wrote and edited manuscript; YGW – Commented on study design, reviewed data, edited and commented on manuscript. All authors read and approved the final manuscript.
Ethics approval and consent to participate
This study was approved by the Institutional Review Board. Informed Consent was waived due to the retrospective nature of the study.
Consent for publication
The authors declare that they have no competing interest.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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