Improving physical activity, pain and function in patients waiting for hip and knee arthroplasty by combining targeted exercise training with behaviour change counselling: study protocol for a randomised controlled trial
Osteoarthritis often results in prolonged periods of reduced physical activity and is associated with adverse health outcomes, including increased risk of cardiovascular and metabolic diseases. Exercise interventions for patients on the waiting list for arthroplasty can reduce the risk of long-term adverse outcomes by increasing activity levels. However, uptake and ongoing positive rates of physical activity in this population are low and the impact of pre-operative behaviour counselling on exercise is not known.
The exercise and behaviour change counselling (ENHANCE) trial is a two-arm assessor-blind randomised controlled trial to assess the effectiveness of a 12-week exercise intervention designed to improve long-term physical activity and functional abilities for people awaiting arthroplasty. Participants on the waiting list for hip and knee arthroplasty are recruited from one clinical site in Australia. After collection of baseline data, participants are randomised to either an intervention or control group. The control group receive usual care, as recommended by evidence-based guidelines. The intervention group receive an individualised programme of exercises and counselling sessions. The 12-week exercise programme integrates multiple elements, including up to five in-person counselling sessions, supported by written materials. Participants are encouraged to seek social support among their friends and self-monitor their physical activity. The primary outcome is physical activity (daily step count and percentage of day spent in sedentary activities). Secondary outcomes include pain ratings, physical function, psychosocial factors and changes in clinical markers linked with potential common chronic diseases (diabetes and cardiovascular disease). All outcomes are assessed at baseline and 26 weeks later and again at 26 weeks post-surgery.
This study seeks to address a significant gap in current osteoarthritis management practice by providing evidence for the effectiveness of an exercise programme combined with behaviour counselling for adults waiting for hip and knee arthroplasty. Theory-driven evidence-based strategies that can improve an individual’s exercise self-efficacy and self-management capacity could have a significant impact on the development of secondary chronic disease in this population. Information gained from this study will contribute to the evidence base on the management of adults waiting for hip and knee arthroplasty.
Australian New Zealand Clinical Trials Registry, ACTRN12617000357358. Registered on 8 March 2017.
KeywordsOsteoarthritis Physical activity and Health Action Process Approach
Accredited exercise physiologist
Analysis of covariance
Exercise and behaviour change counselling
Health Action Process Approach
- HR max
Maximum heart rate
Maximal voluntary contraction
Short Form 12-item health survey on medical outcomes
Osteoarthritis (OA) is a common musculoskeletal problem, which affects over 40% of adults over the age of 70 years  and is associated with substantial pain and disability . Patients with advanced OA of the hip or knee are often referred for surgery to replace the affected joints. Internationally, the waiting time for surgery varies from 6 to 12 months . Due to pain, physical activity levels in patients with OA are substantially lower than levels in non-arthritic older people . The prolonged periods of reduced physical activity during the wait for elective surgery significantly increase the risk of developing other major health problems, such as cardiovascular and metabolic diseases . Inactivity may exacerbate physical impairments, such as muscle weakness, resulting in an increased rate of functional decline  and reduced rate of recovery post-surgery. In contrast, substantial research supports the benefits of regular physical activity in the prevention and treatment of chronic medical conditions including OA [7, 8] at all stages of the disease.
Previous research has largely concentrated on the effects of pre-operative exercise on post-operative pain and mobility . Despite small improvements of 10% in physical activity after joint replacement, activity remains much lower than in healthy people . The reason for this is unknown but may be because patients’ adherence to exercise tends to drop over time  and clinicians often do not appreciate and promote exercise as a treatment option . Consequently, the immediate small positive benefits in pain and mobility are not sustained, as participants are not adequately supported to maintain exercise levels once the intervention finishes. An individualised intervention programme with a counselling component may address the challenge of achieving prolonged increases in physical activity for patients with OA.
Physical activity interventions based on social psychological theory are more effective than atheoretical ones in promoting health-protective behaviour . In addition, interventions are more cost-effective when they have theoretically devised approaches and clearly measurable constructs. A theoretical basis for the intervention components and inclusion of key psychological measures based on theory can demonstrate how the intervention works, highlighting the processes by which behaviour change occurs . The Health Action Process Approach (HAPA)  stipulates a dual-phase approach to action: a motivational phase (i.e. outcome expectancy, risk perception, action self-efficacy and intention) and a volitional phase (i.e. maintenance self-efficacy, recovery self-efficacy, action planning, coping planning and action control). According to HAPA, intention is a necessary but insufficient condition for action initiation and persistence. People also need to identify effective volitional self-regulatory strategies to enact their intentions and prevent relapse. The effectiveness of HAPA-based interventions has been demonstrated in multiple populations and contexts and across multiple health behaviours [15, 16, 17, 18, 19, 20, 21]. The use of this framework to promote physical activity in people with OA does not appear in the literature. However, HAPA has recently been used to identify six physical activity attributes that are most salient to adults with knee OA , which supports this framework in this population.
This report describes the methodology of the ENHANCE trial, a randomised controlled trial to test the effectiveness of the ENHANCE programme for a usual care control group. This study seeks to test the hypothesis that the combination of a targeted exercise prescription with behaviour change counselling based on HAPA will be more effective than usual care in increasing the number of daily steps at all-time points after intervention. Concurrently less pain, improved function and reduced metabolic and cardiovascular risks factors will be recorded.
The study is conducted in Australia at Launceston, Tasmania. The ENHANCE programme is delivered in an exercise physiology clinic at a major university.
To be eligible to participate in the trial, patients have to meet the following criteria: new and existing patients on the surgery waiting list (<6 months on list), aged 80 years and younger (due to older people being less mobile and more sedentary and having more comorbidities and poorer cognition), able to read and understand English, willing to participate in a 12-week exercise intervention and provide informed consent.
Patients will be ineligible to participate in the trial if they meet one or more of the following criteria: an unstable medical condition whereby participation in exercise may present an additional health risk as determined by the consulting surgeon, prior diagnosis of a progressive neurological condition (e.g., Parkinson’s disease) or confined to a wheelchair.
Eligible participants will be invited by a nurse researcher attached to the Launceston General Hospital Orthopaedic Services to participate in the study. They will be provided with an information package and consent form. Potential participants will be provided with further information by a researcher who is an AEP. The AEP will also conduct additional clinically relevant screening of potential participants for conditions that could be made worse by exercise. Participants do not receive any incentives.
Development of the ENHANCE programme
The development of the ENHANCE programme has followed a two-stage process and is informed by the HAPA. First, international guidelines on the development of exercise interventions for adults waiting for hip or knee surgery were reviewed. These guidelines recommend that exercise interventions for people with OA should be multi-dimensional and include exercise to improve whole-body muscle strength, mobility and aerobic capacity. It was, therefore, determined that including participants with both hip and knee arthroplasty widens the applicability of this trial, especially as the current activity levels for both cohorts are similar following arthroplasty.
Second, a series of interviews with people with OA and experienced health-care professionals was conducted. A draft intervention was then produced, which was refined by expert consensus.
Description of the intervention
The ENHANCE programme is a 12-week programme consisting of 24 group classes of progressive exercise intervention combined with five group counselling sessions, delivered after the exercise class. Groups will commence and continue as discrete groups with a maximum of five participants per group. The classes are run twice a week for 60 min each. All sessions are delivered by an AEP. In accordance with recent recommendations for chronic disease management and physical activity guidelines, the intervention is stage-adapted and participants are encouraged to exercise within their own capabilities, which depend on individual symptomatology. Participants in the intervention group also receive an ENHANCE workbook, which includes printed material tailored for people with OA and informed by the principles of HAPA. The workbook was developed by the research team (Additional file 1) and includes general information about the benefits of exercise, setting goals, forming habits and making plans. The booklet describes various activities, which are either scheduled as part of the behaviour counselling face-to-face sessions or are reflective activities for participants to complete at home.
Supervised (twice weekly)
40–60% HR max, 12–14 repetitions; walking, cycling or arm ergometry
Low to moderate intensity (40–60% HR max, 12–14 repetitions); a home programme aiming to accumulate 20–30 min a day for 2–5 days a week will be progressively introduced where safe and practical
Flexibility: static stretching
Building to 3–5 stretches of up to 30 s duration
Initially, once daily at home to comfortable end of range (up to 15 s holds)
Strengthening isometric exercises
40% MVC with up to 10 holds for up to 6 s
Where safe and practical, this will be expanded to the home exercise programme and repeated daily
Strengthening isotonic exercises with TheraBands
40% MVC up to 15 repetitions
Will commence at low levels (40% MVC with between 10 and 15 repetitions) and progress when possible to higher loads and fewer repetitions to stimulate strength gains; once weekly
The AEP will regularly review participants’ original or amended goals, participation in their home exercise programme since the previous class, barriers experienced, motivation for exercise, recent symptoms and pain status. Attendance and adverse events will be documented.
Behaviour change counselling programme
Overview of the behavioural counselling components of the ENHANCE intervention
Why is exercise good for me?
Creating plans and habits
Staying in control
Visualising the future
General health benefits of physical activity and recommendations for enhancing physical activity
Goal setting for the end of the intervention
Organisational aspects of the programme
Begin exercising hints and safety tips
Previous success stories
Sharing success stories
Goal setting, action planning and coping for the following week
Identification of individual barriers to and resources for physical activity (significance of social support)
Strategies for dealing with barriers
Goal setting, action planning and coping for the future post-surgery
Proposed HAPA-based intervention components, behaviour change techniques, and potential mediators
Behaviour change techniques
Providing information on the risk factors of a sedentary lifestyle
Providing information on the benefits and advantages of regular walking
Positive outcome expectancy
Establishing confidence to start regular walking
Identification of resources
Modelling (modelling by others)
Formulating the intentions of regular walking
Making plans on when, where, how and with whom to conduct regular walking
Developing strategies to cope with the barriers that may interfere with regular walking
Identification of barriers
Developing confidence in maintaining regular walking with barriers, as well as resuming regular walking if interrupted
Mastery experience (past experience)
Maintenance self- efficacy
Developing strategies to remind and monitor regular walking
Reminders and sign-in table
Participants work with the AEP to identify small, gradual changes to exercise patterns that can be mastered and maintained, rather than drastic changes that are less likely to be maintained over time. This facilitates a sense of mastery and confidence, which can be built upon throughout the intervention to build self-efficacy. Each intervention contact results in a behaviourally specific action plan that specifies exactly what the participant intends to do and when. Also in the contact sessions, barriers and supports are identified, confidence is assessed and problem-solving is discussed as necessary. These steps are repeated during intervention counselling sessions, with goals being adjusted as necessary. Participants are encouraged to set their own goals based on their fitness level and circumstances.
Participants in the control group receive a generic information brochure at their baseline assessment point, Arthritis (osteoarthritis) and exercise, produced by Exercise is Medicine Australia . Otherwise, participants allocated to usual care receive their concomitant care while they are on the surgical waiting list, attending for ENHANCE assessments at 6 months after baseline and at 6 months after their surgery.
The sample size has been determined to be 50 patients in each group to detect an increase of 1200 (24%) daily steps (alpha 0.05, power 0.8) based on research indicating usual changes in step count after lower limb joint replacement . The study that our sample size calculations are based upon experienced a low withdrawal rate of 4%. We have made a conservative estimate of a 10% withdrawal rate and, hence, will recruit 110 participants.
After completing all baseline data collection measures, participants are randomised to either the intervention group or the control group. Participants in the intervention group receive evidence-based physical activity guidelines supervised by an AEP for the 12 weeks. In addition, those in the intervention group receive an instructor-developed exercise booklet, along with innovative counselling classes five times directly after their exercise session. Participants in the control group will receive an information sheet with general advice on the benefits of physical activity for adults with OA. Participants in either group may receive relevant concomitant care and interventions.
The randomisation schedule has been prepared by a researcher independent of the research project using a computer-generated random number table. To conceal randomisation, the independent researcher has prepared consecutively numbered, sealed, opaque envelopes, which are kept in a locked location. As ENHANCE is an exercise intervention, blinding of the participants and the researchers who conduct the exercise sessions is not possible. Outcome assessors will not be involved in the delivery of the intervention and will be blinded to group allocations.
All staff at the trial site have been trained in the study protocol and the procedures for collecting informed consent and assessment data. A data collection training manual has been developed to guide research staff in the administration of the informed consent and data collection procedures. Assessments are completed in person at baseline, at 26 weeks and at 26 weeks post-surgery (Fig. 1). Once the data have been entered into the local database, they will be transferred to the data manager for the trial, who will compare the hard copies with the database to check accuracy. The data manager will check all the primary outcome variables and a randomly chosen 20% of the other variables. If there are any errors in the primary outcomes, or more than 1% errors for other variables, all data will be checked. The database will not include the assigned treatments. These will be recorded in a separate database, so that the statistician analysing the data will remain blind to treatment allocation.
Potential participants complete a brief screening by telephone conducted by the research nurse. During the screen, an in-person baseline assessment is scheduled for eligible participants. Informed consent is obtained before the assessment. All questionnaires are administered by an interviewer. All baseline and follow-up assessments will be conducted at the intervention site.
All assessment sessions (baseline [time 1], week 26 [time 2] and 26 weeks post-surgery [time 3]) will include a measurement of the primary and secondary outcomes. An ENHANCE questionnaire on data related to the HAPA constructs and a range of dimensions related to health outcomes will also be administered (see Table 2). The baseline assessment will collect additional demographic information related to health, medical history and general health status.
Primary outcome measure
The primary outcome measure is daily physical activity (daily step count and percentage of day spent in sedentary activities). Participants will wear an activity monitor (activePAL™) for seven consecutive days. Data from the device will be recorded and uploaded to a computer. These data will be averaged over the 7 days of activity to calculate a daily step count. The percentage of the day spent in sedentary activities will also be recorded. This measure will be taken upon entry to the study (test 1), and at approximately 6 months (test 2), and then at 6 months after surgery (test 3).
The secondary outcomes include assessment of pain, function, general quality of life, clinical markers and psychological HAPA-based constructs. Specifically, tools to gather these data include measures of pain (visual analogue scale), quality of life (Short Form 12-item health survey on medical outcomes or SF-12), function (Oxford Hip and Knee Score) and Timed Up and Go. Clinical markers of comorbidities, such as cardiovascular and metabolic disease, will be assessed at all time points. Clinical markers relating to cardiovascular health (blood pressure), metabolic health (blood glucose and HbA1c) and body composition (waist circumference, body mass index and body fat percentage) will also be recorded. Psychological HAPA-based constructs (see potential mediators in Table 3) will be measured on multi-item psychometric instruments developed using standardised guidelines and validated in previous studies [15, 16, 17, 18, 19, 20, 21] and adapted for use in the current study. All secondary measures will be taken upon entry to the study (test 1), and at approximately 6 months (test 2), and then 6 months after surgery (test 3).
Assessment of pain, function, general quality of life and clinical markers
Physical functional will be measured using the Timed Up and Go assessment . Briefly, this test involves the client standing up from an armless chair and walking around a cone placed 2.44 m in front of the chair, returning to the chair and sitting down. It is a reliable and valid measure of physical function that is used widely in clinical practice .
Quality of life will be evaluated using the SF-12. This survey includes 12 items which capture information on two subscales describing physical well-being (the physical component summary) and mental well-being (the mental component summary). It is validated and has been widely used to measure quality of life in a range of populations [27, 28, 29].
The visual analogue scale is a unidimensional valid measure of pain intensity , which has been shown to be sensitive to clinical change in people with arthritis. The Oxford Hip and Knee Function scales are clinically useful patient self-report tools, originally designed to be administered to determine the efficacy of joint replacement . They contain 12 questions related to the impact of their condition on daily functioning over the previous 4 weeks. The hip assessment tool is valid, reliable and responsive to change . The Oxford Knee Scale has good internal validity .
Three indicators of body composition (body mass index, waist circumference and percent body fat) will be measured. These measures are simple and easy to attain and have been widely used as indicators of cardiovascular disease  and mortality risk  in large-scale population studies. Body mass index will be calculated from height and body weight. Waist circumference will be measured at the narrowest point between the base of the ribcage and the iliac crest as per standard methods. Body fat percentage will be assessed with bio-impedance analysis scales (Tanita BC-1000; Tanita Corp; Tokyo, Japan), which have previously been shown to be a reliable and reproducible method for determining body composition .
Brachial blood pressure will be measured with an aneroid sphygmomanometer by an experienced practitioner using standardised techniques after 5 minutes of seated rest.
Blood measures of metabolic health [blood glucose and glycosylated haemoglobin (HbA1c)] will be measured from finger-prick blood samples using point of care analysers. Random blood glucose will be measured using a Hemocue Point of Care device (Hemocue Glucose 201; Hemocue AB; Angelholm, Sweden), a reliable and valid device for measuring blood glucose . HbA1c will be measured with a DCA Vantage point of care analyser (Siemens Healthcare, Tarrytown, NY). The DCA Vantage analyser has previously been demonstrated to be a reliable and valid method for determining HbA1c .
Assessment of psychological HAPA-based constructs
Regular exercise will be assessed using a multi-item scale. ‘Think about the past week. In general, how often did you do regular exercise?’ Responses are rated from 1 (never) to 4 (very often). ‘Think about the past week. In general, to what extent did you do regular exercise?’ Responses are rated from 1 (never) to 4 (a large extent). In addition, an open format item ‘Think about the entire past week and count, how many days you did exercise (e.g., if you exercised for at least 20 minutes at a time every day then the response is 7)?’
Habit strength is assessed using the four-item Self-Report Behavioural Automaticity Index . A sample item is ‘Do you agree that doing regular exercise is something… I do automatically?’ Responses are rated from 1 (strongly disagree) to 7 (strongly agree).
Intention is assessed with three items. A sample item is ‘In regards to doing regular exercise over the next week, do you agree that… I intend to exercise?’ Responses are rated from 1 (strongly disagree) to 7 (strongly agree).
Attitude is assessed with three items. A sample item is ‘Doing regular exercise over the next week would be… unpleasant.’ Responses are rated on semantic differential scales from unpleasant to pleasant, bad to good, or harmful to beneficial.
Social influence is assessed with four items. A sample item is ‘In regards to doing regular exercise over the next week, do you agree that… People give me support to ensure I regular exercise?’ Responses are rated from 1 (strongly disagree) to 7 (strongly agree).
Perceived Behavioural Control is assessed with four items. A sample item is ‘In regards to doing regular exercise over the next week, do you agree that… I have complete control over whether I do regular exercise?’ Responses were rated from 1 (strongly disagree) to 7 (strongly agree).
Barrier self-efficacy is assessed with five items. A sample item is ‘I am confident I can do regular exercise over the next week… even when I am in pain.’ Responses are rated from 1 (not at all confident) to 7 (definitely confident).
Action planning is assessed with four items. A sample item is ‘In regards to doing regular exercise over the next week, do you agree that I have made a plan regarding… When to regularly exercise?’ Responses are rated from 1 (not at all true) to 7 (definitely true).
Action control is assessed with three items. A sample item is ‘During the last week… I have often had my regular exercise intentions on my mind?’ Responses are rated from 1 (not at all true) to 7 (definitely true).
Participants randomised to the exercise intervention will be allocated to exercise classes based on their starting date and availability. Adherence is categorised as follows: participation in 75% or more of the supervised sessions is excellent, participation in 50–74% of sessions is good, participation in 25–49% of sessions is moderate and participation in less than 25% of the sessions is poor. Adherence to exercise during the exercise intervention will be measured via attendance sheets at group training sessions. After the exercise intervention, participation in the prescribed home exercise will be evaluated via self-report (questionnaire) collected at test 2 and test 3.
Differences in primary and secondary outcomes between groups will be compared using an intention-to-treat analysis. Once a participant is randomised to a study group, they will be considered a trial participant and analysed according to their allocated group, regardless of missing data for follow-ups or the amount of intervention received. Bivariate relationships will be tested with Pearson or Spearman correlations, independent t-tests or Mann–Whitney U tests (to examine relationships between the dependent variables and the independent variables) or chi squared tests for categorical variables. Each primary and secondary outcome will be analysed using a two-way repeated-measures analysis of covariance (ANCOVA) to determine differences between groups (exercise versus usual care) and between time points (test 1, test 2 and test 3). In addition, effects of the intervention targeting the psychological HAPA-based constructs on regular exercise is tested along with the key processes (mediation) involved. Data will be analysed with a linear mixed model with condition as between-participants effects and time points as within-participants effects. A path analysis will be used to determine mediation effects. Data analysis will be performed using statistical software STATA (STATA 13, Stata Corp, College Station, TX, USA) and Mplus. Statistical significance is set at p < 0.05 for all analyses.
All data collected will be regarded as confidential and securely stored.
Eligible participants are assessed for inclusion in the study. All participants are asked to provide written informed consent prior to enrolment in the study.
Ethical and organisational review
Ethical approval for the ENHANCE trial has been granted by the Human Research Ethics Committee (H0016201) at the participating site. The protocol conforms to CONSORT guidelines  for reporting non-pharmacological interventions.
The ENHANCE trial is an intervention designed to improve physical activity participation and health-related outcomes in patients on the waiting list for hip or knee arthroplasty. This study is the first of its kind to use a supervised exercise intervention with behavioural counselling based on HAPA to motivate and change behaviours that support increases in physical activity. Findings from this study will add to the growing research literature on essential components for the optimum delivery of exercise for chronic disease management. Furthermore, this study may yield insights to our understanding of the strengths and limitations of a novel behaviour change intervention that is embedded in an exercise programme for people with a chronic disease, using OA as a model for chronic disease. An exercise intervention that can increase overall physical activity levels and improve individuals’ exercise self-regulatory and self-management capacity could be significant in improving the management in the community of people on the waiting list for hip and knee arthroplasty.
The authors acknowledge the following limitations: a single-centre trial, lack of a cost-effectiveness analysis, and limited patient and public involvement in the design of the intervention (Additional file 2).
The trial is currently ongoing.
We thank Maureen Ashe for reviewing the protocol and making suggestions. The authors acknowledge the staff at Launceston General Hospital, specifically Jane Niekamp and Michelle Davey, for their assistance with screening and the coordination of the project.
This work is supported by the Clifford Craig Foundation.
Availability of data and materials
The datasets supporting the conclusions of this article will be included in a peer-reviewed manuscript.
JM, JF, AW, MLB, SW and JOB conceived of the study and contributed to the concept development, grant application and ethical approval. JM, JF, AW, MLB, JOB, SW and MC participated in the design of the exercise aspect of the study. JM, JF, AW, MLB, JOB, MC and KH participated in the development of the education sessions. MC has participated in the delivery of the intervention. All authors read and approved the final manuscript.
Ethics approval and consent to participate
Ethical approval was gained prior to recruitment of participants.
Consent for publication
Informed written consent was received from all participants.
The authors declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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