How I ventilate an obese patient
Acute respiratory distress syndrome
Predicted body weight
Positive end-expiratory pressure
Ventilator-induced lung injury
Induction and intubation
During induction and intubation, difficult ventilation and airway management must be anticipated, as the use of sedatives and neuromuscular blocking agents determine early loss of lung aeration and airway collapse in obese patients. We recommend the application of non-invasive positive pressure ventilation pre-oxygenation to improve gas exchange and procedural safety . During the intubation phase, the fraction of inspired oxygen (FiO2) can be safely kept at 100% to increase the oxygen reserve. Alternative strategies including video laryngoscopes and supraglottic devices must be readily available, as well as fluids and vasoactive drugs to face hemodynamic impairment.
Setting up initial mechanical ventilation
Once a safe airway is ensured, FiO2 can be lowered to avoid potentially harmful hyperoxia. Tidal volume size (VT) is a major determinant of VILI and should be titrated based on the predicted body weight (PBW) rather on the actual body weight. We recommend targeting VT to 4–6 and 6–8 ml/kg PBW in patients with and without acute respiratory distress syndrome (ARDS), respectively, taking into account the high discrepancy between predicted and actual body weight in obese patients . We prefer using volume—versus pressure-controlled mode, due to the frequent occurrence of airway closure in obese patients and observational data suggesting clinical advantages in surgical patients at high risk of developing postoperative pulmonary complications . While PEEP increases end-expiratory lung volume and prevents airway collapse, it is associated with hemodynamic impairment and its optimal clinical use in obese is debated. In patients with healthy lungs, we suggest starting with a low-moderate PEEP of 5–8 cmH2O, while considering the ARDS Network low-PEEP table as a standard of care in obese ARDS patients .
Titrating mechanical ventilation parameters
Overall, we suggest targeting gas exchange when titrating ventilation settings, as most obese patients can safely maintain PaO2 55–80 mmHg and SatO2 88–94% and carbon dioxide levels resulting in pHa > 7.25, also tolerating mild hypercapnia, especially in ARDS patients. We suggest changing FiO2 and respiratory rate as first methods to achieve these goals, respectively. However, using elevated respiratory rates may lead to increase intrinsic PEEP (PEEPi) due to airway closure and expiratory flow limitation. We strongly recommend to inspect visually the expiratory flow-time curve and to perform an expiratory hold when the presence of PEEPi is suspected. Driving pressure (∆P), i.e., the difference between plateau pressure (Pplat)—PEEP, was not associated with mortality in obese ARDS patients ; however, this parameter has an important role in VILI and should be ideally limited to a maximum value of 17 cmH2O in ARDS and 15 cmH2O in non-ARDS obese patients. Titration of PEEP levels is controversial. Hemodynamic is more frequent than respiratory impairment in obese patients without ARDS . We prefer prioritizing FiO2 increase over PEEP increase in patients with ARDS. Increases in PEEP should never result in an increase of ∆P, as it suggests hyperinflation and could result in worse clinical outcome . However, a low-PEEP strategy might not ensure acceptable oxygenation in all patients. In patients with persistent hypoxemia, we consider using higher PEEP levels titrated on the lowest ∆P in a decremental PEEP trial [9, 10] or based on transpulmonary pressure . In an observational study, higher PEEP was associated with better survival in ARDS obese patients , but definitive evidence is lacking, and we recommend balancing the negative effects of PEEP, especially on hemodynamics.
Assessing harmfulness of mechanical ventilation
Planning rescue strategies
We do not consider routine recruitment maneuvers as part of the standard ventilatory management of obese patients, but rather as a rescue tool in case of refractory gas exchange impairment, to be performed with gradual changes in the ventilator settings, such as stepwise increases in PEEP and/or inspiratory pressures . Prone positioning has an established role as a rescue therapy in ARDS patients, and its feasibility, safety, and effectiveness have also been shown in obese patients . When these conventional rescue therapies fail, extracorporeal membrane oxygenation should be considered.
The use of neuromuscular blocking agents and opioids should be limited in obese patients, in both cases preferring short-acting molecules and those with an effective antidote. Non-invasive ventilation support can be considered following extubation in selected patients .
In conclusion, mechanical ventilation of obese patients poses specific challenges, reflecting the profound pathophysiologic alterations frequently seen in this population. Education and training among health care professionals to improve knowledge and team working are the keys to optimize mechanical ventilation aiming at better clinical outcomes.
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