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Permissive hypotensive resuscitation in patients with traumatic hemorrhagic shock

  • Kai-Hung Ho
  • Yih-Wen Tarng
  • Yi-Pin ChouEmail author
  • Hsing-Lin LinEmail author
Open Access
Commentary

Abstract

We read the article “Risks and benefits of hypotensive resuscitation in patients with traumatic hemorrhagic shock: a meta-analysis” by Natthida Owattanapanich et al. with great interest and found it to be insightful. In our commentary, we propose possible reasons why mortality was lower in the permissive hypotension group and how the need for blood transfusion decreased in this group. No significant difference in acute kidney injury (AKI) was evident among patient groups, possibly because all these patients might have AKI. However, we do agree that permissive hypotension is of considerable benefit to trauma patients and worth further study.

To the Editor:

Sir,

We read the article “Risks and benefits of hypotensive resuscitation in patients with traumatic hemorrhagic shock: a meta-analysis” by Natthida Owattanapanich et al. [1] with great interest. The study provided the evidences of using hypotensive resuscitation for reducing mortality, the need for blood transfusions, the incidence of acute respiratory distress syndrome, and multiple organ dysfunction in traumatic hemorrhagic shock patients without inducing significant acute kidney injury (AKI). Permissive hypotension might be used for critical patients who require transfer to trauma center or pre-operation in extreme situations. Short-term hypotension is acceptably tolerated if the bleeding in the trauma patient is not severe, which signifies that the patient may only have small-artery bleeding rather than large-vessel injury. However, if patients condition continues to deteriorate, intravenous fluids should be immediately administered because such patients are at a high risk of mortality. Therefore, compared with patients not subject to aggressive resuscitation efforts, it is not surprising that the mortality rate is higher among these patients.

In addition, the need for blood transfusion can be reduced in patients who receive appropriate procedures to stop bleeding—time is a critical factor in the process. If the bleeding can be stopped in a short time through timely appropriate treatment, the necessary volume of blood transfused can be reduced, obviating the need for permissive hypotension. Time is also critical in cases of AKI when the patient is in shock, but AKI can occur in any patient experiencing shock regardless of whether they receive aggressive resuscitation. Therefore, it is difficult to compare the outcome of AKI in patients all have AKI. Younger patients are known to recover faster from AKI; therefore, subgroup analysis could be performed on the basis of age.

In permissive hypotension, a trauma patient is treated with restricted fluid resuscitation, and permissive hypotension is a major topic in trauma research recently [2]. Another treatment employed during operation is deliberate hypotension, which is applied during orthopedic surgery [3]. These two treatments aim to control systolic blood pressure, maintaining it within 80–100 mmHg, and to decrease bleeding from the arteries of an injured person or an operative site. Permissive hypotension can be applied preoperatively and perioperatively; however, after bleeding is stopped through invasive interventions, it is necessary to maintain normal blood pressure and sufficient urine output. Permissive hypotension can be applied in trauma patients who respond to resuscitation; however, major trauma patients who do not respond to resuscitation, even aggressive fluid resuscitation, may have higher mortality, and permissive hypotension should not be applied in these patients.

Currently, no consensus strategy governs when or how to administer permissive hypotension during resuscitation. Further study should investigate the acceptable duration of low blood pressure and its tolerability.

Notes

Acknowledgements

Not applicable.

Funding

No funding was received for this commentary. The authors paid the article processing charges.

Availability of data and materials

Data sharing is not applicable to this article because no data sets were generated or analyzed during the current study.

Authors’ contributions

HLL conceived the commentary. All three authors (KHH, YWT, and YPC) contributed equally to the writing of the manuscript. All authors read and approved the final manuscript.

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

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References

  1. 1.
    Owattanapanich N, Chittawatanarat K, Benyakorn T, Sirikun J. Risks and benefits of hypotensive resuscitation in patients with traumatic hemorrhagic shock: a meta-analysis. Scand J Trauma Resusc Emerg Med. 2018;26:107.CrossRefGoogle Scholar
  2. 2.
    Chatrath V, Khetarpal R, Ahuja J. Fluid management in patients with trauma: restrictive versus liberal approach. J Anaesthesiol Clin Pharmacol. 2015;31:308–16.CrossRefGoogle Scholar
  3. 3.
    Jiang J, Yue Y, Bo L, Zhou R. Deliberate hypotension for orthopaedic surgery. Cochrane Database Syst Rev. 2016. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012096/epdf/full.

Copyright information

© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors and Affiliations

  1. 1.Division of Trauma Surgery, Department of EmergencyKaohsiung Veterans General HospitalKaohsiungTaiwan
  2. 2.Division of Acute Care Surgery, Department of Critical Care MedicineKaohsiung Veterans General HospitalKaohsiung CityTaiwan
  3. 3.Division of Thoracic Surgery, Department of SurgeryKaohsiung Veterans General HospitalKaohsiungTaiwan
  4. 4.Department of OrthopaedicKaohsiung Veterans General HospitalKaohsiungTaiwan
  5. 5.Department of Cosmetic ScienceCollege of Human Ecology, Chang Gung University of Science and TechnologyTaoyuanTaiwan

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