Repaired coarctation of the aorta, persistent arterial hypertension and the selfish brain
It has been estimated that 20–30% of repaired aortic coarctation (CoA) patients develop hypertension, with significant cardiovascular morbidity and mortality. Vertebral artery hypoplasia (VAH) with an incomplete posterior circle of Willis (ipCoW; VAH + ipCoW) is associated with increased cerebrovascular resistance before the onset of increased sympathetic nerve activity in borderline hypertensive humans, suggesting brainstem hypoperfusion may evoke hypertension to maintain cerebral blood flow: the “selfish brain” hypothesis. We now assess the “selfish brain” in hypertension post-CoA repair.
Time-of-flight cardiovascular magnetic resonance angiography from 127 repaired CoA patients (34 ± 14 years, 61% male, systolic blood pressure (SBP) 138 ± 19 mmHg, diastolic blood pressure (DBP) 76 ± 11 mmHg) was compared with 33 normotensive controls (42 ± 14 years, 48% male, SBP 124 ± 10 mmHg, DBP 76 ± 8 mmHg). VAH was defined as < 2 mm and ipCoW as hypoplasia of one or both posterior communicating arteries.
VAH + ipCoW was more prevalent in repaired CoA than controls (odds ratio: 5.8 [1.6–20.8], p = 0.007), after controlling for age, sex and body mass index (BMI). VAH + ipCoW was an independent predictor of hypertension (odds ratio: 2.5 [1.2–5.2], p = 0.017), after controlling for age, gender and BMI. Repaired CoA subjects with VAH + ipCoW were more likely to have difficult to treat hypertension (odds ratio: 3.3 [1.01–10.7], p = 0.049). Neither age at time of CoA repair nor any specific repair type were significant predictors of VAH + ipCoW in univariate regression analysis.
VAH + ipCoW predicts arterial hypertension and difficult to treat hypertension in repaired CoA. It is unrelated to age at time of repair or repair type. CoA appears to be a marker of wider congenital cerebrovascular problems. Understanding the “selfish brain” in post-CoA repair may help guide management.
Journal subject codes
High Blood Pressure; Hypertension; Magnetic Resonance Imaging (MRI); Cardiovascular Surgery; Cerebrovascular Malformations.
KeywordsCoarctation Hypertension Circle of Willis Vertebral artery
Body mass index
Coarctation of the aorta
Diastolic blood pressure
Incomplete posterior circle of Willis
Magnetic resonance angiography
Systolic blood pressure
Sympathetic nerve activity
Vertebral artery hypoplasia
Coarctation of the aorta (CoA) occurs in approximately 4/10,000 live births, accounting for 4–6% of all congenital heart defects [1, 2]. CoA is associated with increased risk of multiple cardiovascular complications including coronary artery disease, aortic aneurysm formation and cerebrovascular disease [3, 4, 5]. Arterial hypertension occurs in approximately 30% following CoA repair [6, 7] and is a unifying risk factor. Upper body hypertension would be predicted if CoA repair was inadequate  or if subsequent growth of the arch or repaired segment was suboptimal . However, hypertension is common even in the presence of a good repair [3, 5, 10] and associated with autonomic imbalance . Age at the time of the original CoA repair has been shown to contribute to subsequent risk of hypertension . However, a high prevalence of hypertension has been subsequently demonstrated in children aged 7–16 years who were treated for CoA at a median age of 0.2 years and without residual significant arch obstruction . Consequently, the reason why hypertension is so common in repaired CoA remains enigmatic.
Recently, our group investigated the role of the “selfish brain” hypothesis in the development of hypertension in-vivo, in human . Humans with hypertension had higher prevalence of vertebral artery hypoplasia (VAH) and incomplete posterior circle of Willis (ipCoW), which was coupled with elevated cerebrovascular resistance (CVR) and diminished cerebral blood flow. Importantly, CVR was increased prior to the development of arterial hypertension and elevated sympathetic nerve activity (SNA) in untreated borderline hypertensive subjects, suggesting that the cerebral hypoperfusion occurred prior to overt activation of the sympathetic nervous system.
We now investigate the role of the “selfish brain” in hypertension following CoA repair. The hypothesis was that VAH with ipCoW (VAH + ipCoW) would be more prevalent in the repaired CoA population developing arterial hypertension compared to normotensive controls and this would predict the development of hypertension after CoA repair.
Aortic MRA had been performed in all repaired CoA subjects to assess for repair site complications. Briefly, following the injection of 0.1 mmol/kg of intravenous gadobutrol (Gadovist, Bayer Pharma AG, Berline, Germany), a 3D systemic arterial MRA at 1.5 T (Avanto, Siemens Healthineers, Erlangen, Germany) from thoracic apex to groins was acquired (TR/TE = 3.1/10.9 ms, flip angle = 25 degrees, voxel size = 1.1x1x1mm, matrix 448 × 265). Intracranial time of flight MRA is routinely performed at the time of first presentation imaging surveillance in all new subjects with history of repaired CoA presenting to our Adult Congenital Heart Disease Unit to screen for intracranial aneurysms as previously described . In brief, a 3D time-of-flight MRA at 1.5 T (Avanto, SiemensHealthineers) with dedicated head coil to assess arterial anatomy (TR 38 ms, TE 5.28 ms, flip angle 25 degrees, voxel size 0.7 × 0.5 × 0.8 mm, field of view 200 mm, covering major arteries feeding into the circle of Willis. The normotensive controls were scanned using 3 T (GE HDx, General Electric Healthcare, Waukesha, Wisconsin, USA) to generate a 3D time-of-flight MRA (TR/TE 24/2.7 ms flip angle 20 degrees, voxel size 0.34 × 0.34 × 0.5 mm3, field of view 192x192x85 mm3).
Aortic MRA analysis
Source aortic MRA data were routinely reported by a consultant cardiovascular radiologist and retrospectively independently reviewed by an imaging cardiologist with > 2 years’ experience blinded to clinical details, including CoA repair type, degree of residual narrowing and normotensive/hypertensive state. As previously described [15, 16], re-coarctation was defined when the diameter of the repaired CoA segment divided by the diameter of the descending thoracic aorta at the diaphragmatic hiatus was < 40%. Re-coarctation on imaging could not be directly assessed in stent repair due to artifact. However, there were no clinical features (such as arm-leg SBP discrepancy) to suggest a clinically relevant re-coarctation in any post-CoA repair subjects. Arch hypoplasia was assessed by the ratio of the minimum mid aortic arch diameter to the descending thoracic aorta at the level of the left atrium, as previously . Multi-planar reformatted gadolinium-enhanced aortic MRA images were also reviewed for the presence of renal artery stenosis, defined as as > 50% focal reduction in vessel diameter .
Intracranial arterial MRA analysis
Statistical analysis was performed using SPSSv.21 (Statistical Package for the Social Sciences (SSPS), International Business Machines, Inc., Armonk, New York, USA). An overall sample size of 49 provides a power of > 80% to find a 27% difference (estimated from a prior study ) in the prevalence of VAH between the two groups, with a two-sided type one error of 0.05. All data analysis was blinded. Normality was determined by the Shapiro-Wilks test. Differences between: 1) controls and CoA subjects and 2) CoA subjects with VAH + ipCoW and CoA subjects without VAH + ipCoW were assessed by unpaired Students t-tests, independent samples Mann-Whitney U tests or Fisher’s exact tests as appropriate. Binary logistic regression analysis was performed to determine differences, controlling for age, male gender and body mass index (BMI), in odds ratios for: 1) the presence of VAH + ipCoW in CoA compared to normotensives and 2) the presence of a diagnosis of hypertension in subjects with VAH + ipCoW compared to those without. Differences in prevalence of VAH + ipCoW between CoA hypertensive and non-hypertensive subgroups was assessed with a Fisher’s exact test. Univariate and multivariate regression analysis was performed to assess for determinants of VAH + ipCoW in repaired CoA subjects. Where appropriate, data are reported as mean ± standard deviation, median with range, as a percentage or odds ratio with 95% confidence intervals. All statistical tests were two-tailed. Significance was set at P < 0.05.
Baseline demographics and cerebrovascular variant prevalence
(n = 33)
(n = 127)
42 ± 14
34 ± 14
Male gender n [%]
24 ± 3
25 ± 5
Office SBP (mmHg)
124 ± 10
138 ± 19
Office DBP (mmHg)
76 ± 8
76 ± 11
Vertebral artery and Circle of Willis data
VAH n [%]
ipCoW n [%]
VAH + incomplete pCoW n [%]
VAH and ipCoW occurs more frequently in repaired CoA than controls
We addressed the question: does VAH and ipCoW occur more frequently in repaired CoA subjects, a requisite if the “selfish brain” hypothesis is implicated in the development of hypertension following repaired CoA. Odds ratios from multivariate logistic regression analysis, controlling for age, male gender and BMI, showed that patients with repaired CoA (n = 127) were 5.8 times more likely to have VAH + ipCoW than controls (n = 33)(β: 5.795, 95th CI: 1.614–20.812, p = 0.007) but age (β: 1.013, 95th CI: 0.985–1.041, p = 0.37), male gender (β: 1.429, 95th CI: 0.681–2.999, p = 0.35) and BMI (β: 1.038, 95th CI: 0.966–1.115, p = 0.31) were not significant predictors of VAH and ipCoW.
VAH and iCoW is a predictor of hypertension in repaired CoA
Next, we sought to answer the question: does VAH + ipCoW predict hypertension following CoA repair? Prevalence of VAH and ipCoW in coarctation with hypertension (n = 64) was significantly higher than controls (n = 33) (44% vs 9%, p < 0.0001, Fisher’s exact test). Additionally, the prevalence of VAH and ipCoW in coarctation without hypertension or anti-hypertensive medication (n = 63) was significantly higher than controls (n = 33) (29% vs 9%, p = 0.037, Fisher’s exact test). There were no differences in percentage restenosis at the site of CoA repair (17 ± 27% vs 16 ± 19%, p = 0.74) or degree of arch hypoplasia (arch hypoplasia index: 0.79 ± 0.20 vs 0.76 ± 0.17, p = 0.32) between repaired CoA cohorts with or without hypertension. However, there was only a trend towards higher prevalence of hypertension in repaired CoA with VAH + ipCoW compared to those without (61% vs 44%, p = 0.097) but repaired CoA subjects with VAH + ipCoW had higher SBP (145 ± 20 vs 134 ± 18 mmHg, p = 0.003) despite more having anti-hypertensive medications prescribed (54% vs 33%, p = 0.025). Furthermore, repaired CoA subjects with VAH + ipCoW and hypertension were older than those without hypertension (38 ± 11 vs 30 ± 12 years, p = 0.035).
In multivariate logistic regression analysis, correcting for age, male gender and BMI, VAH + ipCoW was a significant independent predictor of a diagnosis of hypertension; where present, this increased the odds of a diagnosis of hypertension independently by 2.5 times (β: 2.473, 95th CI: 1.173–5.212, p = 0.017).
VAH ipCoW is associated with higher BP and uncontrolled hypertension
Subgroup analysis of repaired CoA subject with and without VAH + ipCoW
Repaired coarctation patients
No VAH + ipCoW
(n = 81)
VAH + ipCoW
(n = 46)
33 ± 14
35 ± 12
Male gender n [%]
25 ± 5
26 ± 5
Blood pressure data
Office SBP (mmHg)
134 ± 18
145 ± 20
Office DBP (mmHg)
75 ± 10
77 ± 11
Uncontrolled HTNa n [%]
On anti-HTN Rx n [%]
ACEi /ARB n [%]
CCB n [%]
Beta-blocker n [%]
Other congenital heart defects
Bicuspid aortic valve n [%]
Coarctation repair datab
Age at repair (years)
End to End repair n [%]
Subclavian flap n [%]
Patch repair n [%]
Angioplastyc n [%]
Recoarctation n [%]
Not all subjects with repaired CoA and VAH + ipCoW had hypertension. Subgroup analysis demonstrated that subjects with repaired CoA, VAH + ipCoW and hypertension (n = 28) were significantly older than subjects with repaired CoA, VAH + ipCoW without hypertension (n = 18) (38 ± 11 vs 30 ± 12 years, p = 0.035, Student’s t-test) but there were no significant differences in BMI (26 ± 5 vs 26 ± 7 kg/m2, p = 0.99, Student’s t-test) or sex (75% (21/28) male vs 56% (10/18) male, p = 0.21, Fisher’s Exact test). There were no significant differences in prevalence of repair types between repaired CoA with VAH + ipCoW and hypertension compared to those without hypertension. In addition, Amongst subjects with repaired coarctation but without VAH + ipCoW, those with hypertension were older than those still normotensive (37 ± 15 vs 29 ± 11 years, p = 0.013, Student’s t-test).
Determinants of VAH and ipCoW in repaired CoA
Univariate and multivariate logistic regression for determinants of VAH + ipCoW in repaired CoA
OR (95% CI)
OR (95% CI)
Age at time of repair (years)
End to End repair
Subclavian flap repair
Balloon / Stent angioplasty
For the first time, we investigated the “selfish brain” hypothesis in hypertension following surgical CoA repair. Our novel findings are: 1) there is a higher prevalence of VAH + ipCoW in repaired CoA patients than controls, 2) VAH + ipCoW is an independent predictor of hypertension after controlling for age, gender and BMI, 3) repaired CoA subjects with VAH + ipCoW are more likely to have higher BP and uncontrolled hypertension than those without and 4) neither the age at time of repair nor any specific repair type were significant predictors of VAH + ipCoW. Together, these findings suggest that VAH + ipCoW in repaired CoA subjects may be congenital or acquired, independent of the timing and type of repair and could account for the development of hypertension or its persistence, following CoA repair.
SNA is elevated in most hypertensive humans [21, 22, 23] and in patients with a history of CoA and hypertension . However, the driver behind the elevated SNA is not clear. Both work in the spontaneously hypertensive rat model  and post-mortem humans studies  have suggested that brain blood flow is crucial in determining SNA and therefore systemic arterial pressure. At post-mortem, Dickinson and Thomason demonstrated that vertebral arteries in patients with ante-mortem hypertension were narrower than those who were normotensive ante-mortem and that vertebral artery resistance correlated positively with ante-mortem blood pressure . This paved the way for the development of “the selfish brain hypothesis” of hypertension, which proposes that vertebral artery narrowing with resultant brainstem hypoperfusion results in neurogenic-mediated increases in SNA in an attempt to increase systemic pressure to compensate for the decreased brain blood flow  . This is supported by rat data that demonstrate that vertebrobasilar artery hypertrophy occurs prior to the development of hypertension and that brainstem ischaemia from bilateral vertebral artery clamping results in significantly increased SNA in pre-hypertensive spontaneously hypertensive rats compared to age-match normotensive rats . Moreover, the brainstem of the spontaneously hypertensive rat is hypoxic compared to the normotensive rat at the same level of blood oxygenation and blood pressure, both at hypertensive levels and markedly so when blood pressure falls .
Recently, our group provided in-vivo evidence for the “selfish brain” hypothesis by demonstrating that humans with hypertension had a higher prevalence of VAH + ipCoW, which was coupled with elevated cerebrovascular resistance and diminished cerebral blood flow . Importantly, cerebral vascular resistance was increased prior to the development of hypertension and elevated SNA was also increased in untreated borderline hypertensive subjects, suggesting a causal link . The findings of the current study provide the first evidence to support a similar pathophysiological process occurring in, at least some, subjects following CoA repair. All patients with repaired CoA undergo assessment of their blood pressure on an annual basis, but it may be that those with VAH + ipCoW need to have more vigilant assessment with more frequent ambulatory blood pressure monitoring, for example.
Our findings raise several important questions. Firstly, when does VAH + ipCoW occur in subjects with CoA? There are at least two possibilities: 1) VAH + ipCoW occurs as a result of CoA, in an attempt to protect the brain from elevated perfusion pressures that may occur in the face of the central aortic obstruction or 2) VAH + ipCoW occurs in conjunction with CoA as a manifestation of a more widespread congenital vascular abnormality. If the former is the case, the severity and duration of the aortic obstruction would likely be important factors in the development of the cerebrovascular variants but we did not demonstrate age at time of repair to be a significant predictor of VAH + ipCoW. The fact that subjects with CoA manifest pathological adjustment of autonomic cardiovascular homeostasis as early as the neonatal period before surgical repair  supports the latter developmental hypothesis. Future longitudinal follow-up studies of subjects with CoA, starting as early as in-utero, with genotyping and paired serial MRI assessments of cerebrovascular anatomy / resistance and assessment of SNA will help further clarify the answer to this question. Interestingly, amongst repaired coarctation subjects without VAH + ipCoW, those who were hypertensive were old than those who were normotensive. It is possible that a significant proportion of patients with repaired coarctation are still destined to become hypertensive and the presence of VAH + ipCoW may accelerate this process. Longitudinal studies will also help address this hypothesis.
Regardless of the etiology of the VAH + ipCoW, it is interesting to postulate the impact of the current management of relieving the central aortic obstruction on the cerebral perfusion in individuals with VAH + ipCoW. The anticipated reduction in central aortic pressure following treatment for CoA could potentially aggravate cerebral perfusion in individuals with at risk vasculature. Indeed, in previous work, treatment controlled hypertensive participants had significantly lower cerebral perfusion than normotensive controls  and cerebral blood flow has been demonstrated to be lower in patients with CoA . If this were the case, CoA repair may actually predispose certain subjects to increased neurogenic-mediated SNA. Supporting this notion, increased SNA has been documented in patients after CoA repair  and so-called paradoxical hypertension after treatment of CoA is well-recognized . Determining the prevalence of VAH + ipCoW pre and post intervention, as well as assessing for change in cerebrovascular resistance and perfusion and SNA before and after treatment, will be important to determine the treatment effect on cerebrovascular function.
An important question that remains unanswered is: why do some patients with repaired CoA and VAH + ipCoW develop hypertension and others do not? The current study provides one possible explanation; the group with VAH + ipCoW without hypertension were significantly younger than the group with VAH + ipCoW and hypertension. It is possible that the subjects with the cerebrovascular variants have yet to develop hypertension in this single time-point cross-sectional study. Cerebral autoregulation appears to be impaired in CoA patients , which supports this notion. Longitudinal follow-up for this subgroup in particular will be important to document the incidence of hypertension. It is also important to realize that not all cases of hypertension following CoA repair can be attributed to VAH + ipCoW. There are many other potential causes including endothelial dysfunction  and arterial stiffness , either inherent or due to the presence of a stent as well as suboptimal haemodynamic repair. Additionally, there are other potential considerations that could specifically account for elevated SNA and hypertension beyond VAH + ipCoW, such as renovascular causes of hypertension.
This was retrospective analysis of a prospective database of repaired CoA subjects surviving to adulthood to be seen in a tertiary adult congenital heart disease clinic in the South West of England. This will unavoidably have introduced an element of survival bias into the study sample. This also constrained our analysis to anatomical assessment of VAH + ipCoW. However, our previous work has described the pathophysiological mechanisms associated with this finding in subjects with and without hypertension, which we assume to be similar in the current cohort . In particular, it was demonstrated that the contralateral vertebral artery does not compensate for the hypoplastic artery in terms of cerebral perfusion .
The lack of ambulatory blood pressure data in all subjects is a limitation.
No large differences in surgical repair type were found. However, the absolute numbers in these subgroups is small. Future study is warranted in a larger cohort to detect smaller differences between surgical repair types, particularly since young children undergoing subclavian flap repair have previously been demonstrate to have higher blood pressure and stiffer upper limb arteries compared with matched children undergoing end-to-end anastomosis .
VAH + ipCoW predicts hypertension and difficult to treat hypertension in repaired CoA. It is unrelated to age at time of repair or repair type. CoA may be a marker of wider congenital cerebrovascular problems. Understanding the “selfish brain” in CoA repair may help in identifying those patients at highest risk of developing hypertension, although further research is needed to guide an effective treatment strategy.
NIHR Cardiovascular Biomedical Research Centre at The University of Bristol NHS Foundation Trust and The University of Bristol. The views expressed are those of the authors and not necessarily those of the National Health Service, National Institute for Health Research, or Department of Health and Social Care.
JCLR conceived the study, acquired data, analysed data, drafted the manuscript. MJ,MW, KM, SL acquired data and revised the manuscript. AKN, MCKH, SLC, NEM, JFRP and ECH provided critical intellectual input and revised the manuscript. All authors read and approved the final manuscript.
Cardiovascular magnetic resonance imaging was funded by the NIHR Bristol Cardiovascular Biomedical Research Unit.
JCLR: Clinical Society of Bath Postgraduate Research Bursary 2014 and Royal College of Radiologists Kodak Research Scholarship 2014.
ECH: British Heart Foundation Intermediate Research Fellow (IBSRF FS/11/1/28400). JFRP: British Heart Foundation (RG/12/6/29670).
Ethics approval and consent to participate
All participants gave informed written consent.
Consent for publication
The authors declare that they have no competing interests.
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