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BMC Gastroenterology

, 19:176 | Cite as

Pneumatosis cystoides intestinalis: a case report and literature review

  • Fangmei Ling
  • Di Guo
  • Liangru ZhuEmail author
Open Access
Case report
  • 148 Downloads
Part of the following topical collections:
  1. Intestinal disorders

Abstract

Background

Pneumatosis cystoides intestinalis (PCI) is a low-incidence disease that confuses many doctors. A vast number of factors are suspected to contribute to its pathogenesis, such as Crohn’s disease, intestinal stenosis, ulcerative colitis, drug use, extra-gastrointestinal diseases, and chronic obstructive pulmonary disease. Most consider its pathogenesis interrelated to an increase in intra-intestinal pressure and the accumulation of gas produced by aerogenic bacteria, and patients with atypical symptoms and imaging manifestations tend to be misdiagnosed.

Case presentation

A 64-year-old man complained of a 3-month history of bloody stool without mucopurulent discharge, abdominal pain, or diarrhea. Colonoscopy revealed multiple nodular projections into the segmental mucosa of the sigmoid colon. Crohn’s disease and malignant disease ware suspected first according to the patient’s history, but laboratory examinations did not confirm either. Endoscopic ultrasound (EUS) revealed multiple cystic lesions in the submucosa. Moreover, computer tomography scan showed multiple bubble-like cysts. Combined with ultrasonography, computed tomography, and pathology findings, we ultimately made a diagnosis of PCI. Instead of surgery, we recommended conservative treatment consisting of endoscopy and oral drug administration. His symptoms improved with drug therapy after discharge, and no recurrence was noted on follow-up.

Conclusions

The incidence of PCI is low. Due to a lack of specificity in clinical manifestations and endoscopic findings, it often misdiagnosed as intestinal polyps, tumors, inflammatory bowel disease, or other conditions. Colonoscopy, computed tomography, and ultrasonography have demonstrated benefit in patients with multiple nodular projections in colon. Compared to the treatment of the above diseases, PCI treatment is effective and convenient, and the prognosis is optimistic. Therefore, clinicians should increase their awareness of PCI to avoid unnecessary misdiagnosis.

Keywords

Pneumatosis cystoides intestinalis Differential diagnosis Treatment 

Background

Pneumatosis cystoides intestinalis (PCI) was first reported by Du Vernoi in 1730 [1]. In a systematic review and analysis of 239 patients with PCI, Wu et al. reported that the peak age at onset was 45.3 ± 15.6 years (range, 2–81 years), the male to female ratio was 2.4:1, and the mean disease course was 6 months [2]. After examining 123 patients with PCI, Boerner reported an equal incidence in male and female patients and that remission was achieved in 70% of patients using nonsurgical treatment [3].

PCI is distributed throughout the digestive tract, particularly the subserous or submucosa of the small intestine and colon, in which multiple pneumocysts develop. The distal stump of the transverse splenic flexure colon, particularly the descending and sigmoid colon, is most commonly affected [2].

Case presentation

A 64-year-old man presented to the gastroenterology inpatient department with bloody stool in August 2017. There was no obvious cause of bloody stool before the patient was admitted to the hospital 3 months prior with mucus and blood attached to formed stools. The patient had no clear symptoms of abdominal pain, abdominal distension, tenesmus, fever, or night sweats. His weight had decreased by about 9 kg since he first became ill. He had a 5-year history of diabetes that was controlled by acarbose. A physical examination revealed no abnormalities. Laboratory investigations revealed no abnormalities except platelets count of 95 G/L. Colonoscopy revealed multiple nodular projections in the segmental mucosa of the sigmoid colon, some of which were transparent (Fig. 1a). Endoscopic ultrasound (EUS) revealed multiple cystic lesions in the submucosa, followed by ringing artifacts (Fig. 1b). We suspected that the patient had pneumatosis intestinalis based on the EUS findings.
Fig. 1

Endoscopic and CT examination. a Colonoscopy disclosed multiple nodular lesions in the transverse colon and sigmoid colon. b Endoscopic ultrasonography showed hypoechoic lesions (white allows). c CT Horizontal scan. Image adjusted to lung window (black allows). d CT Horizontal scan. Image adjusted to abdominal window (black allows). e CT Vertical scan. Multiple grape-like gases were visible in sigmoid colon ((black allows)

We performed further examinations to confirm the diagnosis. Intestinal computed tomography (CT) scan showed intramural gas in the sigmoid colon only (Fig. 1c, d, e). Consequently, the diagnosis of PCI was gradually established. To obtain better management, we used forceps to break the sac wall to exhaust the gas. The white bulge of the submucosa resembled a bubble after we used a snare to resect the surface of the mucosa with high-frequency electroscission (Fig. 2a, b, c). After being punctured by needles, the bubbles collapsed and the mucosa was removed and sent for pathological examination (Fig. 2d). Chronic mucosal inflammation was noted (Fig. 2e). The patient’s symptoms resolved, and he was cured 3 months later after administering intestinal flora microecological therapy and other conservative medical treatments (Fig. 2f). In addition to administering 5-aminosalicylic acid, we recommended that the patient discontinue the use of alpha-glucosidase inhibitor (α-GI) in the follow-up. No recurrence of digestive tract symptoms or other discomfort occurred during the 1 year of follow-up.
Fig. 2

Imaging and pathological features. a Cystic nodules were seen, with mucosal hyperemia and erosion. b Image after mucosal surface resection. c White bubble-like lesions of submucosa were seen. d Cyst collapse after fine needle puncture. e Pathology revealed chronic inflammation. f Colonoscopy showed that the surface of the mucosa was smooth

Discussion and conclusions

PCI can be divided into primary (15%) and secondary (85%) types [2, 4]. The secondary type occurs secondary to diseases such as digestive tract stenosis, obstructive pulmonary disease, abdominal external injury or surgery, and malnutrition [2, 3]. There are three hypotheses of PCI pathogenesis: (1) mechanical theory: involving an increase in intraluminal pressure that causes mechanical damage and mucosal rupture of the intestinal wall, leading to the migration of gas from the gastrointestinal cavity to the intestinal wall [1]; (2) pulmonary theory: chronic lung diseases such as chronic obstructive pulmonary disease, asthma, and interstitial pneumonia lead to alveolar rupture, causing mediastinal emphysema and release of gas along the aorta and mesenteric blood vessels into the intestinal wall [5]; and (3) bacterial theory: aerogenic bacteria penetrate the intestinal mucosal barrier, ferment in the intestinal wall, and produce gas [6].

In the present case, the patient was taking an alpha-glucosidase inhibitor (α-GI) to control blood glucose. Some scholars reported that α-GI use was associated with the pathogenesis of PCI [7, 8]; α-GIs suppress the absorption of carbohydrates by inhibiting α-GI activity. Carbon dioxide, hydrogen, methane, and other metabolites are produced by the fermentation of carbohydrates. Meanwhile, pneumocysts are formed due to increased intraluminal pressure, which is attributed to peristaltic hypofunction associated with diabetes mellitus and gas-producing bacteria breaking through the mucosal integrity and invading the mucosa. Patients improve with conservative treatment, such as fasting, fluid replacement, and discontinuation of α-GIs. Since about 30% of Japanese diabetic patients use α-GIs, recent reports on the relationship between α-GIs and PCI have been published primarily in Japan [7]. Kojima reported a case of PCI associated with miglitol [9]. However, whether the etiology of PCI is related to α-GIs requires further exploration. Therefore, in clinical practice, when patients with diabetes complain of gastrointestinal symptoms, the possibility of PCI should be considered.

PCI lesions are mainly located in the colon (46%) and small intestine (27%), followed by the large and small intestine (7%) and stomach (5%) [10]. The clinical manifestations of primary PCI are nonspecific, such as abdominal pain (59%), diarrhea (53%), nausea and vomiting (14%), mucus in stool (12%), and hematochezia (12%) [2]. Secondary PCI also has primary disease manifestations. About 3% of the patients with PCI complained of complications, including pneumoperitoneum, volvulus, intestinal obstruction, and intestinal ischemia [1, 2, 11, 12, 13]. Serious complications may alter the decision-making process for the therapeutic schedule.

The laboratory examination and pathological biopsy of PCI are nonspecific; the diagnosis mainly depends on colonoscopy, CT, radiography, and ultrasound findings. However, it is easily confused with intestinal polyps [14], cancer [15], or inflammatory bowel disease [16], necrotising enterocolitis [17], even if colonoscopy and biopsy are performed due to a lack of awareness of PCI. Many cases can be found in clinical practice in which patients with pneumoperitoneum signs were initially misdiagnosed as having digestive tract perforation and suffered from unnecessary surgery [18, 19, 20].

Some researchers reported that the abdominal CT characteristics of PCI are multiple submucosal or subserosal cystic transmission areas that resemble a bunch of grapes [12]. Furthermore, CT images taken at different levels enable estimation of lesion location and extent through three-dimensional scanning. The image can be observed more clearly when adjusted to the lung window. The discovery of the presence of gas in the portal vein is one of the advantages of CT examination, which is particularly important for making therapeutic decisions. Lassandro et al. found that gas in the portal vein was present in approximately 25.5% of PCI patients. In these patients, the incidence of intestinal obstruction increased and the mortality rate increased to 50% [21]. EUS has high diagnostic value in PCI: multiple cystic lesions without echoes are visible at the sigmoid colon with rear ringing artifacts. EUS provides reliable imaging evidence for making a definitive diagnosis. Ribaldone et al. mentioned that EUS is effective for analyzing the nature and source of intestinal masses, which is a unique advantage [22].

Although the diagnosis of PCI mainly depends on medical imaging, biopsy is still highly recommended. First, the endoscopic manifestations of PCI patients usually present as polypoid or protuberant lesions. With the development of industrialized countries in the twenty-first century, the incidence of Crohn’s disease and colon cancer has continually increased and concomitantly, the number of colonoscopy examinations [23, 24]. The symptoms, location, and endoscopic manifestations of PCI are also similar to those of other diseases, such as inflammatory bowel disease, intestinal neoplasms, and intestinal polyps [14, 15, 16]. Additionally, PCI has been associated with Crohn’s disease and both can coexist in the same patient [25]. Moreover, the specific etiology of Crohn’s disease combined with PCI is unclear, which may be a result of the surgical history of Crohn’s disease patients [26]. A pathological biopsy cannot be neglected in this situation and can be conducive for accurate and systematic analysis. Pathological findings of giant cell arrays and partial or collapsed cysts may be helpful in differentiating PCI [27]. Therefore, increasing the doctor’s understanding of PCI is imperative for proper management. Making correct judgments on PCI avoids increasing the psychological and economic burden on patients and unnecessary medical procedures, such as mucosal dissection and surgery, especially by doctors in grassroots units, whose clinical experience is relatively lacking.

If a PCI is suspected, CT examination and ultrasound endoscopy should be performed when conditions permit, and the factors causing PCI should be explored. In addition to gastrointestinal diseases and emphysema, some rare events are associated to PCI, such as alpha-glucosidase inhibitors [7], sunitinib [20], lung transplantation [28], bone marrow transplantation [29], systemic lupus erythematosus [30], systemic sclerosis [11], myeloma [31], granulomatosis with polyangiitis [32]. Moreover, the mucosal damage caused by colonoscopy and biopsy may result in the gas entering the intestinal mucosa, thereby promoting the occurrence of PCI [33]. Therefore, it is not enough to reach a superficial diagnosis, as more examination are necessary to investigate the disease etiology. In our case, the cause of PCI could be related to the use of α-GI. It is worth mentioning that in 2019 we re-enrolled a patient with PCI who also had a history of taking acarbose, who is currently undergoing treatment. For patients with PCI, we should investigate their medical history as far as possible, inquring about the recent use of alpha-glucosidase inhibitor, multi-tyrosine kinase inhibitor, glucocorticoid, and other drugs, exploring whether there is a combination of lung diseases, gastrointestinal diseases, diabetes, autoimmune diseases, cancer history, and organ transplantation history. At the same time, combined with medical history is beneficial to pertinently screen the pathogeny and eliminate potential influencing factors, such as mucosal damage, increased intestinal pressure, and bacterial infection. A thorough assessment of the clinical background of PCI and the correct comprehension of the differential diagnosis of PCI is essential to avoid unnecessary surgery.

Most researchers believe that PCI is a benign disease with conservative treatments: (1) observation; (2) oxygen or hyperbaric oxygen therapy. Kensuke Nakatani et al. reported that hyperbaric oxygen therapy is the preferred method [32]; (3) antibiotics including metronidazole and quinolones can inhibit intestinal bacterial infection; and (4) endoscopic treatment. Endoscopic fine needle aspiration contributes to the diagnosis and treatment of PCI, by puncturing the cyst to exhaust gas [34, 35, 36, 37]. PCI-induced intestinal obstruction can be treated by the high-freguency endoscopic resection of the cyst wall, and cyst collapse after gas discharge [36]. Because the presence of multiple sites of operations and biopsies increase the risk of infection by nearly 9 times, local implementations are generally recommended [36, 37]. However, some patients developed intestinal obstruction again after relieving the first obstruction. At this point, sclerotherapy of the cyst wall after puncture may be a solution to prevent the cyst from expanding again [18].

Surgical intervention is not absolutely necessary to treat PCI. How accurately identifying the timing of surgery has become a clinical challenge. Generally speaking, the prognosis of PCI is good, and the poor predictors of prognosis include pH value < 7.3, bicarbonate level < 20 ml/L, lactate level > 2 mmol/L, amylase level > 200 U/L, and presence of portal venous gas [4, 11, 13, 38]. A level of > 2 mmol/l of lactate was the strongest predictor of pathological PCI and correlated with adverse outcomes [13]. In order to more rapidly identify and manage patients with severe PCI, patients should be divided into three groups: patients requiring surgery, patients with invalid surgery, and patients with benign intestinal emphysema. The primary operative indications are considered if the patient meets any of the following criteria: obstructive symptoms, WBC > 12 c/mm3 or CT findings of portal vein gas, especially when the patient is older than 60 years old, due to the high mortality rate associated with this condition. For secondary indications, if patients have sepsis or signs of acidosis (pH < 7.3, lactate > 2.0, bicarbonate < 20), surgery should be performed [4]. Patients with acute abdomen, acute kidney injury, or hypotension can also be treated surgically [38]. Accordingly, PCI patients should undergo detailed physical examination and as well as renal function and blood-gas analysis, CT, and tests for amylase and C-reactive protein levels, along with other tests, so as to quickly identify patients who need surgery and patients who can be relieved by conservative treatment. Although lactic acid was not detected in our case, the patient was evaluated for benign PCI from abdominal signs, white blood cells, blood pressure, and CT. Therefore, non-surgical treatments to eliminate cysts were selected. PCI is relatively unfamiliar to inexperienced clinicians, and an optimal PCI management model has yet to be suggested.

To conclude, PCI is a not uncommon disease with male predominance and unclear etiology and pathogenesis. Because abdominal pain, diarrhea, and other nonspecific abdominal symptoms are the main clinical manifestations, it is easily confused with intestinal polyps, cancer, or inflammatory bowel disease. With increase in the number of endoscopies, it is essential to improve the doctor’s comprehension of PCI. The diagnosis mainly depends on abdominal CT and colonoscopy findings. For example, CT shows a number of grape-like or beaded low-density cystic light transmission areas. Treatment includes observation, oxygen therapy, endoscopic treatment, and surgery. The treatment should be tailored to the clinical symptoms and endoscopic manifestations to avoid unnecessary surgery. If no serious complications occur, the prognosis is optimistic.

Notes

Acknowledgements

We sincerely thank the department of pathology and radiology in our hospital for providing information.

Authors’ contributions

FL wrote the manuscript and acquired information of the patient. DG performed literature review and followed-up. LZ revised the manuscript. All authors have read and approved the final manuscript.

Funding

This case report was not supported by relevant funds.

Ethics approval and consent to participate

Not applicable

Consent for publication

We have obtained the patient’s consent and signed the patient consent. A copy of the written consent is available for review from the Editor-in-Chief of this journal.

Competing interests

The authors declare that they have no competing interests. All authors have confirmed that no support from any organization for the submitted work; no financial relationships with any organization that might have an interest in the submitted work in the previous 3 years, no other relationships or activities that could appear to have influenced the submitted work.

References

  1. 1.
    Khail PN, Huber-Wagner S, Ladurner R, Kleespies A, Siebeck M, Mutschler W, Halfeldt K, Kanz KG. Natural history, clinical pattern, and surgical consideration of pneumatosis interstialis. Eur J Med Res. 2009;14(6):231–9.CrossRefGoogle Scholar
  2. 2.
    Wu L-L, Yang Y-S, Dou Y, Liu Q-S. A systemic analysis of pneumatosis cystoids intestinalis. World J Gastroenterol. 2013;19(August (30)):4973–8.PubMedPubMedCentralCrossRefGoogle Scholar
  3. 3.
    Boerner RM, Frie DB, Warshauer DM, Isaacs K. Pneumatosis intestinalis. Two case reports and a retrospective review of literature from 1985 to 1995. Dig Dis Sci. 1996;41(11):2272–85.PubMedCrossRefGoogle Scholar
  4. 4.
    Greenstein AJ, Nguyen SQ, Berlin A, Corona J, Lee J, Wong E, Factor SH, Divino CM. Pneumatosis intestinalis in adults: managements, surgical indivations, and risk factors for mortality. J Gastrointest Surg. 2007;11(10):1268–74.PubMedCrossRefGoogle Scholar
  5. 5.
    Keyting WS, McCarver RR, Kovarik JL, Daywitt AL. Pneumatosis intestinalis: a new concept. Radiology. 1961;76:733–41.PubMedCrossRefGoogle Scholar
  6. 6.
    Gillon J, Tadesse K, Logan RF, Holt S, Sircus W. Breath hydrogen in pneumatosis cystoides intestinalis. Gut. 1979;20:1008–11.PubMedPubMedCentralCrossRefGoogle Scholar
  7. 7.
    Tsujimoto T, Shioyama E, Moriya K. Pneumatosis cystoides intestinalis following alpha-glucosidase inhibitor treatment: a case report and review of the literature. World J Gastroenterol. 2008;14(39):6087–92.PubMedPubMedCentralCrossRefGoogle Scholar
  8. 8.
    Hayakawa T, Yoneshima M, Abe T, Nomura G. Pneumatosis cystoides intestinalis after treatment with an alpha-glucosidase inhibitor. Diabetes Care. 1999;22:366–7.PubMedCrossRefGoogle Scholar
  9. 9.
    Kojima K, Tsujimoto T, Fujii H, Morimoto T, Yoshioka S, Kato S, Yasuhara Y, Aizawa S, Sawai M, Makutani S, Yamamoto K, Mochi T, Fukui H. Pneumatosis cystoides intestinalis induced by the α-glucosidase inhibitor miglitol. Intern Med. 2010;49(15):1545–8.PubMedCrossRefGoogle Scholar
  10. 10.
    Morris MS, Gee AC, Cho SD, Limbaugh K, Underwood S, Ham B, Schreiber MA. Management and outcome of pneumatosis intestinalis. Am J Surg. 2008;195(5):679–82.PubMedCrossRefGoogle Scholar
  11. 11.
    Kanchela D, Vattikuti S, Vipperla K. Pnematosis cystoides intestinalis: is surgery always indicated? Cleve Clin J Med. 2015;82(3):151–2.CrossRefGoogle Scholar
  12. 12.
    Ogul H, Pirimoglu B, Kisaoglu A, Karaca L, Havan N, Ozogul B, Kantarci M. Pneumatosis cystoides intestinalis: an unusual cause of intestinal ischemia and pneumoperitoneum. Int Surg. 2015;100(2):221–4.PubMedPubMedCentralCrossRefGoogle Scholar
  13. 13.
    DuBose JJ, Lissauer M, Maung AA, Piper GL, O'Callaghan TA, Luo-Owen X, Inaba K, Okoye O, Shestopalov A, Fielder WD, Ferrada P, Wilson A, Channel J, Moore FO, Paul DB, Johnson S. Pneumatosis intestinalis predictive evaluation study (PIPES):a multicenter epidemiologic study of the eastern association for the surgery of trauma. J Trauma Acute Care Surg. 2013;75(1):15–23.PubMedCrossRefGoogle Scholar
  14. 14.
    Ponz de Leon M, Bertarelli C, Casadei GP, Grilli A, Bacchini P, Pedroni M, Jovine E. A case of pneumatosis cystoides intestinalis mimicking familial adenomatous polyposis. Familial Cancer. 2013;12(3):573–6.PubMedCrossRefGoogle Scholar
  15. 15.
    Liu T, Zhang S, Mao H. Gastrointestinal malignant neoplasms disguised as pneumatosis cystoids intestinalis: a case report and literature review. Medicine (Baltimore). 2017;96(51):e9410.CrossRefGoogle Scholar
  16. 16.
    Suarez V, Chesner IM, Price AB, Newman J. Pneumatosis cystoides intestinalis. Histological mucosal changes mimicking inflammatory bowel disease. Arch Pathol Lab Med. 1989;113(8):898–901.PubMedGoogle Scholar
  17. 17.
    Ang CH, Li XF, Ong LY, Low Y. Pneumatosis Intestinalis in meconium inspissation mimicking Necrotising Enterocolitis. Indian J Pediatr. 2017;84(4):328–9.PubMedCrossRefGoogle Scholar
  18. 18.
    Johansson K, Lindström E. Treatment of obstructive pneumatosis coli with endoscopic sclerotherapy: report of a case. Dis Colon Rectum. 1991;34(1):94–6.PubMedCrossRefGoogle Scholar
  19. 19.
    Dhadie S, Mehanna D, McCourtney J. Pneumatosis intestinalis a trap for the unway: case series and literature review. Int J Surg Case Rep. 2018;53:214–7.CrossRefGoogle Scholar
  20. 20.
    Lee YS, Han JJ, Kim SY, Maeng CH. Pneumatosis cystoides intestinalis associated with sunitinib and a literature review. BMC Cancer. 2017;17(1):732.PubMedPubMedCentralCrossRefGoogle Scholar
  21. 21.
    Lassandro F, Mangoni de Santo Stefano ML, Porto AM, Grassi R, Scaglione M, Rotondo A. Intestinal pneumatosis in adults: diagnostic and prognostic value. Emerg Radiol. 2010;17(5):361–5.PubMedCrossRefGoogle Scholar
  22. 22.
    Ribaldone DG, Bruno M, Gaia S, Saracco GM, De Angelis C. Endoscopic ultrasound to diagnose pneumatosis cystoides intestinalis (with video). Endosc Ultrasound. 2017;6(6):416–7.PubMedPubMedCentralCrossRefGoogle Scholar
  23. 23.
    Kaplan GG. The global burden of IBD: from 2015 to 2025. Nat Rev Gastroenterol Hepatol. 2015;12(12):720–7.PubMedCrossRefGoogle Scholar
  24. 24.
    Mármol I, Sánchez-de-Diego C, Pradilla Dieste A, Cerrada E, Rodriguez Yoldi MJ. Colorectal carcinoma: a general overview and future perspective in colorectal cancer. Int J Mol Sci. 2017;18(1):197.PubMedCentralCrossRefGoogle Scholar
  25. 25.
    Galandiuk S, Fazio VW, Petras RE. Pneumatosis cystoides intestinalis in Crohn’s disease. Report of two cases. Dis Colon Rectum. 1985;28(12):951–6.PubMedCrossRefGoogle Scholar
  26. 26.
    Breitinger A, Kozarek R, Hauptman E. Pneumatosis cystoides intestinalis in Crohn’s disease. Gastrointest Endosc. 2003;57(2):241.PubMedCrossRefGoogle Scholar
  27. 27.
    Koreishi A, Lauwers GY, Misdraji J. Penmatosis intestinalis:a challenging biopsy diagnosis. Am J Surg Pathol. 2007;31(10):1469–75.PubMedCrossRefGoogle Scholar
  28. 28.
    Beetz O, Kleine M, Vondran FWR, Cammann S, Klempnauer J, Kettler B. A case of recurrent pneumoperitoneum and pneumatosis intestinalis after bilateral lung transplan. Exp Clin Transplant. 2019;17(1):124–7.PubMedCrossRefGoogle Scholar
  29. 29.
    Day DL, Ramsay NK, Letourneau JG. Pneumatosis intestinalis after bone marrow transplantation. AJR Am J Roentgenol. 1988;151(1):85–7.PubMedCrossRefGoogle Scholar
  30. 30.
    Marinello DK, Rafael D, Paiva Edos S, Dominoni RL. Systemic lupus erythematosus complicated by intestinal vasculitis and pneumatosis intestinalis. Rev Bras Reumatol. 2010;50:596–602.PubMedCrossRefGoogle Scholar
  31. 31.
    Raghunathan V, Louis D, Wirk B. Gastrointestinal tract amyloidosis presenting with pneumatosis intestinalis. J Clin Med Res. 2017;9(7):654–8.PubMedPubMedCentralCrossRefGoogle Scholar
  32. 32.
    Nakatani K, Kato T, Okada S, Matsumoto R, Nishida K, Komuro H, Suganuma T. Successful treatment with hyperbaric oxygen therapy for pneumatosis cystoides intestinalis as a complication of granulomatosis with polyangiitis: a case report. J Med Case Rep. 2017;11:263.PubMedPubMedCentralCrossRefGoogle Scholar
  33. 33.
    Deer M, Altorfer J, Pirovino M, Schmid M. Pneumatosis cystoides coli: a rare complication of colonoscopy. Endoscopy. 1983;15:119–20.CrossRefGoogle Scholar
  34. 34.
    Cyrany J, Kopácová M, Rejchrt S, Hornychová H, Tomsová M, Tycová V, Ryska A, Bures J. Puncture and cytology - sufficient for endoscopic diagnosis of pneumatosis cystoides intestinalis? Endoscopy. 2009;41(Suppl 2):E127–8.PubMedCrossRefGoogle Scholar
  35. 35.
    Takahashi K, Fujiya M, Ueno N, Ando K, Kashima S, Moriichi K, Okumura T. Endoscopic fine-needle aspiration is useful for the treatment of pneumatosis cystoides intestinalis with intussusception. Am J Gastroenterol. 2019;114(1):13.PubMedCrossRefGoogle Scholar
  36. 36.
    Wang YJ, Wang YM, Zheng YM, Jiang HQ, Zhang J. Pneumatosis cystoides intestinalis: six case reports and a review of the literature. BMC Gastroenterol. 2018;18(1):100.PubMedPubMedCentralCrossRefGoogle Scholar
  37. 37.
    Kim YG, Kim KJ, Noh SH, Yang DH, Jung KW, Ye BD, Byeon JS, Myung SJ, Yang SK. Clear water filling and puncture: sufficient for endoscopic diagnosis of pneumatosis cystoides intestinalis? (with video). Gastrointest Endosc. 2011;74(5):1170–1.PubMedCrossRefGoogle Scholar
  38. 38.
    Tahiri M, Levy J, Alzaid S, Anderson D. An approach to pneumatosis intestinalis: Factors affecting your management. Int J Surg Case Rep. 2015;6:133–137.CrossRefGoogle Scholar

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Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors and Affiliations

  1. 1.Division of Gastroenterology, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

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