Advertisement

Safety of soy-derived phosphatidic acid supplementation in healthy young males

  • Joshua E Dudeck
  • Jordan M Joy
  • Ryan P Lowery
  • Eduardo O De Souza
  • Ralf Jäger
  • Sean A McCleary
  • Stephanie M C Wilson
  • Martin Purpura
  • Jacob M WilsonEmail author
Open Access
Poster presentation

Keywords

Resistance Training Specific Gravity Blood Urea Nitrogen Phosphatidic Acid Muscle Hypertrophy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Background

The mammalian target of rapamycin (mTOR) has been shown to regulate rates of muscle protein synthesis, and one novel nutritional activator of mTOR is the phospholipid Phosphatidic Acid (PA). We have recently found that PA supplementation over 8 weeks of resistance training augmented responses in skeletal muscle hypertrophy and strength. However, we are unaware of research investigating the safety of PA in human subjects. Therefore the purpose of this study was to investigate the effects of 8 weeks of 750 mg per day of PA supplementation on safety parameters in healthy college aged males.

Methods

Twenty-eight healthy, college aged male subjects (21 ± 3 years of age, bodyweight of 76 ± 9 kg, and height of 176 cm ± 9 cm) participated in this study. Subjects were equally divided into experimental and control conditions. The experimental condition (EXP) received 750 mg of soy-derived PA (Mediator™, Chemi Nutra, White Bear Lake, MN), while the control condition (CON) received a visually identical placebo (rice flour). Measures of cardiovascular, kidney, and liver function were analyzed with a full CMP and CBC prior to and 8 weeks following supplementation. This analysis included: total, high density, and low density lipoproteins, blood glucose, blood urea nitrogen, creatinine, eGFR, Na, K, Cl, CO2, Ca, protein, albumin, globulin, albumin:globulin ratio, total bilirubin, alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase. In addition a sample of urine was submitted for analysis of urine specific gravity and pH. A 2x2 repeated measures ANOVA was used to determine group, time, and group x time interactions. A Tukey post-hoc was used to locate differences.

Results

There were no differences at baseline in blood chemistry and hematology between the CON and EXP supplemented groups. Additionally no differences were observed in urinalysis values between the groups. Moreover no group, or group X time effects were found following 8 weeks of supplementation.

Conclusions

Soy-derived PA is a safe nutritional supplement for healthy college aged subjects if taken up to a dosage of 750 mg over an eight week period.

Notes

Acknowledgements

Supported by Chemi Nutra, White Bear Lake, MN, USA.

Copyright information

© Dudeck et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Authors and Affiliations

  • Joshua E Dudeck
    • 1
  • Jordan M Joy
    • 1
  • Ryan P Lowery
    • 1
  • Eduardo O De Souza
    • 2
  • Ralf Jäger
    • 3
  • Sean A McCleary
    • 1
  • Stephanie M C Wilson
    • 4
  • Martin Purpura
    • 3
  • Jacob M Wilson
    • 1
    Email author
  1. 1.Department of Health Sciences and Human PerformanceThe University of TampaTampaUSA
  2. 2.Laboratory of Neuromuscular Adaptations to Strength TrainingSchool of Physical Education and Sport, University of São PauloSão PauloBrazil
  3. 3.Increnovo LLCMilwaukeeUSA
  4. 4.Department of NutritionIMG Performance Institute, IMG AcademyBradentonUSA

Personalised recommendations