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Genetic parameters for resistance to the Salmonella abortusovis vaccinal strain Rv6 in sheep

  • Carole R MorenoEmail author
  • Frédéric Lantier
  • Patricia Berthon
  • Anne V Gautier-Bouchardon
  • Roger Boivin
  • Isabelle Lantier
  • Jean-Claude Brunel
  • Jean-Louis Weisbecker
  • Dominique François
  • Jacques Bouix
  • Jean-Michel Elsen
Open Access
Research

Abstract

An experimental population (1216 lambs from 30 sires) of the Inra401 sheep was created in an Inra flock to allow QTL detection for susceptibility to Salmonella infection, wool and carcass traits. The Inra401 is a sheep composite line developed from two breeds: Berrichon du Cher and Romanov. At 113 days of age on average, the lambs were inoculated intravenously with 108Salmonella abortusovis Rv6 (vaccinal strain). They were slaughtered 10 days after the inoculation. Several traits were measured at inoculation and/or slaughtering to estimate the genetic resistance of the lambs to Salmonella infection: specific IgM and IgG1 antibody titres, body weight loss, spleen and pre-scapular node weights and counts of viable Salmonella persisting in these organs. This paper presents a quantitative analysis of the genetic variability of the traits related to salmonellosis susceptibility. The heritabilities of the traits varied between 0.10 and 0.64 (significantly different from zero). Thus, in sheep as well as in other species, the determinism of resistance to Salmonella infection is under genetic control. Moreover, the correlations between the traits are in agreement with the known immune mechanisms. The genetic variability observed should help QTL detection.

Keywords

genetic parameters Salmonella sheep disease resistance 

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Copyright information

© INRA, EDP Sciences 2003

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors and Affiliations

  • Carole R Moreno
    • 1
    Email author
  • Frédéric Lantier
    • 3
  • Patricia Berthon
    • 3
  • Anne V Gautier-Bouchardon
    • 3
  • Roger Boivin
    • 3
  • Isabelle Lantier
    • 3
  • Jean-Claude Brunel
    • 2
  • Jean-Louis Weisbecker
    • 2
  • Dominique François
    • 1
  • Jacques Bouix
    • 1
  • Jean-Michel Elsen
    • 1
  1. 1.Station d'amélioration génétique des animauxInstitut national de la recherche agronomiqueCastanet-Tolosan CedexFrance
  2. 2.Domaine de Bourges-La SapinièreInstitut national de la recherche agronomiqueOsmoyFrance
  3. 3.Laboratoire de pathologie infectieuse et immunologieInstitut national de la recherche agronomiqueNouzillyFrance

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