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A review on SNP and other types of molecular markers and their use in animal genetics

  • Alain VignalEmail author
  • Denis Milan
  • Magali SanCristobal
  • André Eggen
Open Access
Research

Abstract

During the last ten years, the use of molecular markers, revealing polymorphism at the DNA level, has been playing an increasing part in animal genetics studies. Amongst others, the microsatellite DNA marker has been the most widely used, due to its easy use by simple PCR, followed by a denaturing gel electrophoresis for allele size determination, and to the high degree of information provided by its large number of alleles per locus. Despite this, a new marker type, named SNP, for Single Nucleotide Polymorphism, is now on the scene and has gained high popularity, even though it is only a bi-allelic type of marker. In this review, we will discuss the reasons for this apparent step backwards, and the pertinence of the use of SNPs in animal genetics, in comparison with other marker types.

Keywords

SNP microsatellite molecular marker genome polymorphism 

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Copyright information

© INRA, EDP Sciences 2002

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors and Affiliations

  • Alain Vignal
    • 1
    Email author
  • Denis Milan
    • 1
  • Magali SanCristobal
    • 1
  • André Eggen
    • 2
  1. 1.Laboratoire de génétique cellulaire, InraCastanet-Tolosan cedexFrance
  2. 2.Laboratoire de génétique biochimique et de cytogénétique, InraJouy-en-Josas cedexFrance

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