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Oocyte Donation From Donor Older Than 35 Years. Is It Worth Trying?

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Abstract

Introduction

Due to several reasons, in some countries commercial oocyte donation is not possible. Accordingly, patients should find their own donors who may be over 35 years. The aim of this study was to compare the results of oocyte donation from donors <35 years (young donors) and donors ≥35 years old (older donors).

Material and Methods

A retrospective cohort study was conducted at a single academic reproductive center. We compared the results of oocyte donation from donors <35 years (345 cycles) and from donor ≥35 years old (83 cycles). We also performed subgroup analysis for single embryo transfer (SET) and fresh and frozen embryo transfers.

Results

Recipient demographic characteristics of the 2 groups were comparable. The age of the donors was 29.8 ± 3.9 years in the young donor group and 37.6 ± 2.1 years in the older donor group (P <.0001). Pregnancy and implantation rates in the recipients from young donor group were statistically significantly higher than those from the older donor group (50.7% and 40.9% vs 38.3% and 23%; P =.04, P <.001). Cumulative pregnancy and live birth rates were significantly higher in the young donor group compared to the older donor group (86.1% vs 57.4% P <.0001 and 52.2% vs 33.3%, P =.02, respectively). Subgroup analysis showed comparable pregnancy and live birth rates for SET cycles (45.5% vs 40.4% and 25.0% vs 21.2%, respectively) and fresh cycles (54.7% vs 42.6% and 35.8% vs 29.6%, respectively).

Conclusion

In nonanonymous oocyte donation programs, donation from older donors with good ovarian reserve is an acceptable approach when young donor is not available.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, McGill University, 5771 Eldridge Av, Montreal, Quebec, H4W 2E3, Canada

    Tal Shavit MD, Joseph Hasson MD, Na’ama al Ma’mari MD, Weon-Yong Son PhD, Ahmad Badeghiesh MD, Tannus Samer MD & Togas Tulandi MD, MHCM

  2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Tal Shavit MD, Joseph Hasson MD, Anat Klement-Hershko MD & Amir Wiser MD

Authors
  1. Tal Shavit MD
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  2. Joseph Hasson MD
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  3. Na’ama al Ma’mari MD
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  4. Weon-Yong Son PhD
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  5. Ahmad Badeghiesh MD
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  6. Tannus Samer MD
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  7. Anat Klement-Hershko MD
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  8. Amir Wiser MD
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  9. Togas Tulandi MD, MHCM
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Corresponding author

Correspondence to Tal Shavit MD.

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Authors’ Note

The study was conducted in Montreal, Quebec, Canada, McGill Reproductive Center, McGill University Health Center.

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Shavit, T., Hasson, J., al Ma’mari, N. et al. Oocyte Donation From Donor Older Than 35 Years. Is It Worth Trying?. Reprod. Sci. 26, 503–509 (2019). https://doi.org/10.1177/1933719118776791

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  • DOI: https://doi.org/10.1177/1933719118776791

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