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Impact of Endometrioma Resection on Eutopic Endometrium Metabolite Contents: Noninvasive Evaluation of Endometrium Receptivity

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Abstract

The aim of this study was to determine whether endometrioma resection alters most commonly defined endometrial metabolites, lactate (Lac), N-acetylaspartate (NAA), creatine 1 (Cr1), creatine 2 (Cr2), and choline (Cho) during the window of implantation. Twenty patients with uni- or bilateral endometrioma and 7 patients having nonendometriotic benign ovarian cyst were included. Midluteal phase magnetic resonance spectroscopy analysis of eutopic endometrium was performed before surgery. Second spectrum of endometrium was obtained 3 to 5 months after laparoscopic endometrioma resection. Pre- and postoperative endometrial peaks of Lac, NAA, Cr, and Cho were measured in units and denominated in parts per million (ppm). Compared to preoperative peak values, significantly decreased NAA, Lac, and Cr1 signals were noted in patients undergoing endometrioma surgery. Nearly 5-fold decline in the NAA signal occurred after endometrioma surgery (1.94 ± 3.24 vs 0.37 ± 0.55). Likewise, 2.5-fold decline in Lac signals was noted after endometrioma resection (2.81 ± 2.64 vs 1.06 ± 1.88). Both uni- and bilateral endometrioma affected endometrium signals the same. The peak intensity of Cho, Cr1, Cr2, NAA, and Lac did not alter significantly after nonendometriotic cyst surgery. Endometrioma surgery straightens endometrial NAA, Lac, and Cr1 peaks, suggesting improvement in endometrial receptivity.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Bahcesehir University School of Medicine, Istanbul, Turkey

    Aynur Ersahin MD

  2. Private Clinic, Obstetrics and Gynecology, Usak, Turkey

    Onder Celik MD

  3. Department of Obstetrics and Gynecology, Medipol University School of Medicine, Istanbul, Turkey

    Mustafa Acet MD

  4. Department of Obstetrics and Gynecology, Kemerburgaz University Medical Faculty, Istanbul, Turkey

    Suphan Ersahin MD

  5. Department of Obstetrics and Gynecology, Medicine Hospital, Istanbul, Turkey

    Tuba Acet MD

  6. Department of Radiology, Altinova Private Hospital, Sakarya, Turkey

    Duygu Kara Bozkurt MD

  7. Department of Obstetrics and Gynecology, Istanbul Yeniufuk Hospital, Istanbul, Turkey

    Yasemin Yavuz MD

  8. Department of Medical Pharmacology, Firat University School of Medicine, Elaziğ, Turkey

    Selcuk Ilhan MD

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  1. Aynur Ersahin MD
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  2. Onder Celik MD
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  3. Mustafa Acet MD
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  4. Suphan Ersahin MD
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  7. Yasemin Yavuz MD
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Correspondence to Aynur Ersahin MD.

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Ersahin, A., Celik, O., Acet, M. et al. Impact of Endometrioma Resection on Eutopic Endometrium Metabolite Contents: Noninvasive Evaluation of Endometrium Receptivity. Reprod. Sci. 24, 790–795 (2017). https://doi.org/10.1177/1933719116670039

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  • DOI: https://doi.org/10.1177/1933719116670039

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