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Overexpression of IL-18 in the Proliferative Phase Endometrium of Patients With Polycystic Ovary Syndrome

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Abstract

Women with polycystic ovary syndrome (PCOS) exhibit low implantation rate and high abortion rate. To explore the effect of low-grade chronic inflammation on endometrium of women with PCOS, we investigated the expression of interleukin 18 (IL-18) in the endometrium of 23 women with PCOS and 20 healthy women. Endometrial tissue samples were obtained during hysteroscopic surgery. We found that IL-18 was significantly increased in the endometrium of women with PCOS compared with normal groups. In overweight women, IL-18 was obviously overexpressed in the PCOS group compared to the healthy group. However, in normal-weight women, there was no statistically significant difference between the 2 groups, and there was no significant difference in IL-18 expression in patients having PCOS with or without insulin resistance. We conclude that IL-18 protein and messenger RNA levels are increased in the endometrium of patients with PCOS, and this effect is correlated with body mass index.

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Authors and Affiliations

  1. Department of Obstetrics and, Gynecology, Center of Reproductive Medicine, Peking University Third Hospital, Beijing, 100191, China

    Xiaoyu Long PhD, Rong Li MD PhD, Yan Yang PhD & Jie Qiao MD PhD

  2. Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China

    Xiaoyu Long PhD, Rong Li MD PhD, Yan Yang PhD & Jie Qiao MD PhD

  3. Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China

    Xiaoyu Long PhD, Rong Li MD PhD, Yan Yang PhD & Jie Qiao MD PhD

Authors
  1. Xiaoyu Long PhD
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  2. Rong Li MD PhD
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  3. Yan Yang PhD
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  4. Jie Qiao MD PhD
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Correspondence to Yan Yang PhD.

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Long, X., Li, R., Yang, Y. et al. Overexpression of IL-18 in the Proliferative Phase Endometrium of Patients With Polycystic Ovary Syndrome. Reprod. Sci. 24, 252–257 (2017). https://doi.org/10.1177/1933719116653681

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