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Endometrial Scratch Injury Induces Higher Pregnancy Rate for Women With Unexplained Infertility Undergoing IUI With Ovarian Stimulation: A Randomized Controlled Trial

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Abstract

Objective

To explore the impact of endometrial scratch injury (ESI) on intrauterine insemination (IUI) success.

Methods

One hundred and fifty four infertile women received 100 mg of oral clomiphene citrate for 5 days starting on day 3 of the menstrual cycle. Patients were randomized to 2 equal groups: Group C received IUI without ESI and group S had ESI. Successful pregnancy was confirmed by ultrasound.

Results

13, 21, and 10 women got pregnant after the first, second, and third IUI trials, respectively, with 28.6% cumulative pregnancy rate (PR). The cumulative PR was significantly higher in group S (39%) compared to group C (18.2%). The PR in group S was significantly higher compared to that in group C at the second and third trials. The PR was significantly higher in group S at the second trial compared to that reported in the same group at the first trial but nonsignificantly higher compared to that reported during the third trial, while in group C, the difference was nonsignificant. Eight pregnant women had first trimester abortion with 18.2% total abortion rate with nonsignificant difference between studied groups.

Conclusion

The ESI significantly improves the outcome of IUI in women with unexplained infertility especially when conducted 1 month prior to IUI.

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Authors and Affiliations

  1. Department of Obstetrics & Gynecology, Cairo University, 135 King Faisal Street Haram, Giza, Egypt

    Ahmed M. Maged MD, Hesham Al-Inany MD & Noura Elnassery MD

  2. Department of Obstetrics & Gynecology, Faculty of Medicine, Benha University, Banha, Egypt

    Khaled M. Salama MD, Ibrahim I. Souidan MD & Hesham M. Abo Ragab MD

Authors
  1. Ahmed M. Maged MD
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  2. Hesham Al-Inany MD
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  3. Khaled M. Salama MD
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  4. Ibrahim I. Souidan MD
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  5. Hesham M. Abo Ragab MD
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  6. Noura Elnassery MD
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Correspondence to Ahmed M. Maged MD.

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Maged, A.M., Al-Inany, H., Salama, K.M. et al. Endometrial Scratch Injury Induces Higher Pregnancy Rate for Women With Unexplained Infertility Undergoing IUI With Ovarian Stimulation: A Randomized Controlled Trial. Reprod. Sci. 23, 239–243 (2016). https://doi.org/10.1177/1933719115602776

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