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Is There a Link Between Expression Levels of Histone Deacetylase/Acetyltransferase in Mouse Sperm and Subsequent Blastocyst Development?

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Abstract

Histone acetylation has been known to be significant in spermatogenesis. Histone acetylation is regulated by the act of histone deacetylases (HDACs) and histone acetyltransferases (HATs). We investigated the link between expression levels of HDACs and HATs in mouse sperm and subsequent blastocyst formation rate. In the univariate analysis, expression levels of HDAC1 and HAT were generally not associated with the blastocyst formation rate. When divided by the mature oocyte number category, a significant positive association was observed between the expression levels of HDAC1 and the blastocyst-forming rate in the highest (> 75th) percentile group (a group with ≥34 mature oocytes). In conclusion, expression of sperm HDAC1 could be considered as a possible predictor of embryo development in mice with high ovarian response.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Cha Gangnam Hospital, Cha University, Seoul, South Korea

    Jayeon Kim MD, MPH

  2. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea

    Byung-Chul Jee MD, PhD, Chang-Suk Suh MD, PhD & Seok-Hyun Kim MD

  3. Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, 300 Gumi, Bundang, Seongnam, Gyeonggi, 463-707, Bundang, South Korea

    Jayeon Kim MD, MPH, Ji-Hee Kim MD & Seok-Hyun Kim MD

  4. Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, South Korea

    Byung-Chul Jee MD, PhD & Chang-Suk Suh MD, PhD

Authors
  1. Jayeon Kim MD, MPH
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  2. Ji-Hee Kim MD
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  3. Byung-Chul Jee MD, PhD
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  4. Chang-Suk Suh MD, PhD
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  5. Seok-Hyun Kim MD
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Correspondence to Byung-Chul Jee MD, PhD.

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Kim, J., Kim, JH., Jee, BC. et al. Is There a Link Between Expression Levels of Histone Deacetylase/Acetyltransferase in Mouse Sperm and Subsequent Blastocyst Development?. Reprod. Sci. 22, 1387–1392 (2015). https://doi.org/10.1177/1933719115580997

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  • DOI: https://doi.org/10.1177/1933719115580997

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