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Effectiveness and Safety of Lower Doses of Mifepristone Combined With Misoprostol for the Termination of Ultra-Early Pregnancy: A Dose-Ranging Randomized Controlled Trial

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Abstract

This study aimed to investigate the effectiveness and safety of lower doses of mifepristone combined with misoprostol for the termination of ultra-early pregnancy. A total of 2500 women with ultra-early pregnancy (amenorrhea ≤ 35 days) were randomly divided into 5 groups with gradually decreased dose of oral mifepristone from 150 to 50 mg followed by 200 µg of oral misoprostol 24 hours later. The primary end point was complete abortion without surgical intervention. Secondary end points were vaginal bleeding, return of menses, and side effects. Rates of complete abortion were high in all groups. Moreover, the lower doses of mifepristone led to shorter vaginal bleeding period, the return of menses on the expected date, and fewer side effects. Lower doses of mifepristone combined with 200 µg of misoprostol are as effective and safe as higher doses of this combination for the termination of ultra-early pregnancy with lower possibility of vaginal bleeding and side effects.

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Authors and Affiliations

  1. The Third Affiliated Hospital of Guangzhou Medical University & Key Laboratory for Major Obstetric Diseases of Guangdong Province, 63 Duobao Road, Liwan District, 510145, Guangzhou, China

    Cui-Lan Li MD, PhD, Dun-Jin Chen MD, Li-Ping Song MD, Yan Wang MD, Zhong-Fang Zhang MD, Ming-Xing Liu MD & Wei-Ling Chen MD

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  1. Cui-Lan Li MD, PhD
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  2. Dun-Jin Chen MD
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  3. Li-Ping Song MD
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  4. Yan Wang MD
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  5. Zhong-Fang Zhang MD
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  6. Ming-Xing Liu MD
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  7. Wei-Ling Chen MD
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Correspondence to Cui-Lan Li MD, PhD.

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Li, CL., Chen, DJ., Song, LP. et al. Effectiveness and Safety of Lower Doses of Mifepristone Combined With Misoprostol for the Termination of Ultra-Early Pregnancy: A Dose-Ranging Randomized Controlled Trial. Reprod. Sci. 22, 706–711 (2015). https://doi.org/10.1177/1933719114557897

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