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Mid-Trimester Maternal ADAM12 Levels Differ According to Fetal Gender in Pregnancies Complicated by Preeclampsia

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Abstract

An overrepresentation of adverse pregnancy outcomes has been observed in pregnancies associated with a male fetus. We investigated the association between fetal gender and candidate biomarkers for preeclampsia. Proteins were quantified in samples taken at 20 weeks from women recruited to the SCreening fOr Pregnancy Endpoints (SCOPE) study (preeclampsia n = 150; no preeclampsia n = 450). In contrast to placental growth factor, soluble endoglin, and insulin-like growth factor acid labile subunit, levels of metallopeptidase domain 12 (ADAM12) at 20 weeks were dependent on fetal gender in pregnancies complicated by preeclampsia, for male (n = 73) fetuses the multiples of the median (MoM; interquartile range [IQR] 1.1–1.5) was 1.3, whereas for female fetuses (n = 75) MoM was 1.1 (1.0–1.3); P < .01. Prediction of preeclampsia using ADAM12 levels was improved for pregnancies associated with a male fetus (area under receiver–operator curve [AUC] 0.73 [95% confidence interval [CI] 0.67–0.80]) than that of a female fetus (AUC 0.62 [0.55–0.70]); P = .03. The data presented here fit a contemporary hypothesis that there is a difference between the genders in response to an adverse maternal environment and suggest that an alteration in ADAM12 may reflect an altered placental response in pregnancies subsequently complicated by preeclampsia.

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Authors and Affiliations

  1. Maternal & Fetal Heath Research Centre, Manchester Academic Health Science Centre, University of Manchester, Central Manchester NHS Trust, 5th Floor (Research), St Mary’s Hospital, Oxford Rd, M13 9WL, Manchester, UK

    Jenny E. Myers PhD & Philip N. Baker DM

  2. Pronota, Zwijnaarde, Belgium

    Grégoire Thomas PhD, Robin Tuytten PhD, Yven Van Herrewege PhD & Raoul O. Djiokep MSc

  3. Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, Australia

    Claire T. Roberts PhD

  4. The Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, Ireland

    Louise C. Kenny PhD

  5. Department of Obstetrics and Gynaecology, University of Leeds, Leeds, UK

    Nigel A. B. Simpson MD

  6. Women’s Health Academic Centre, King’s College London, London, UK

    Robyn A. North PhD

  7. Gravida: National Centre for Growth and Development, Liggins Institute, University of Auckland, New Zealand

    Philip N. Baker DM

Authors
  1. Jenny E. Myers PhD
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  2. Grégoire Thomas PhD
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  3. Robin Tuytten PhD
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  4. Yven Van Herrewege PhD
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  6. Claire T. Roberts PhD
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  7. Louise C. Kenny PhD
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  8. Nigel A. B. Simpson MD
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  9. Robyn A. North PhD
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Correspondence to Jenny E. Myers PhD.

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Myers, J.E., Thomas, G., Tuytten, R. et al. Mid-Trimester Maternal ADAM12 Levels Differ According to Fetal Gender in Pregnancies Complicated by Preeclampsia. Reprod. Sci. 22, 235–241 (2015). https://doi.org/10.1177/1933719114537713

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