Skip to main content
SpringerLink
Log in

The Common Single-Nucleotide Polymorphism rs2681472 Is Associated With Early-Onset Preeclampsia in Northern Han Chinese Women

  • Original Article
  • Published:
Reproductive Sciences Aims and scope Submit manuscript

Abstract

Preeclampsia, characterized by hypertension and proteinuria, remains a leading cause of maternal morbidity and mortality. Recently, a genome-wide association study (GWAS) identified the single-nucleotide polymorphism, rs2681472, as a new hypertension susceptibility genetic variant. The purpose of this study was to evaluate the association between preeclampsia and rs268172 in a Northern Han Chinese population. We genotyped 1218 unrelated Northern Han Chinese women, including 515 patients with preeclampsia and 703 healthy controls. No significant differences were detected in the allele frequencies between patients and controls (P = .23). When patients were divided into early-onset and late-onset preeclampsia according to gestational age of disease onset, the allele frequencies significantly differed between controls and patients with early-onset preeclampsia (P = .02). Genotype frequencies also were significantly different between controls and patients early-onset preeclampsia when data were analyzed under additive (P = .03) and dominant (P = .009) models. We replicated this association in an independent Northern Han Chinese population and observed a significant difference in the allele frequencies between patients with early-onset preeclampsia and controls (P = .011). We report that rs2681472 is associated with early-onset preeclampsia in Northern Han Chinese women.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Salonen Ros H, Lichtenstein P, Lipworth L, Cnattingius S. Genetic effects on the liability of developing pre-eclampsia and gestational hypertension. Am J Med Genet. 2000;91(4):256–260.

    Article  CAS  Google Scholar 

  2. Levy D, Ehret GB, Rice K, et al. Genome-wide association study of blood pressure and hypertension. Nat Genet. 2009;41(6): 677–687.

    Article  CAS  Google Scholar 

  3. Kohara K, Tabara Y, Nakura J, et al. Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension. Hypertens Res. 2008;31(2):203–212.

    Article  CAS  Google Scholar 

  4. Cho YS, Go MJ, Kim YJ, et al. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet. 2009;41(5):527–534.

    Article  CAS  Google Scholar 

  5. Hong KW, Go MJ, Jin HS, et al. Genetic variations in ATP2B1, CSK, ARSG and CSMD1 loci are related to blood pressure and/ or hypertension in two Korean cohorts. J Hum Hypertens. 2010; 24(6):367–372.

    Article  CAS  Google Scholar 

  6. Hong KW, Jin HS, Lim JE, Kim S, Go MJ, Oh B. Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population. J Hum Genet. 2010;55(6):336–341.

    Article  CAS  Google Scholar 

  7. Tabara Y, Kohara K, Kita Y, et al. Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese millennium genome project. Hypertension. 2010; 56(5):973–980.

    Article  CAS  Google Scholar 

  8. Takeuchi F, Isono M, Katsuya T, et al. Blood pressure and hypertension are associated with 7 loci in the Japanese population. Circulation. 2010;121(21):2302–2309.

    Article  Google Scholar 

  9. Ho JE, Levy D, Rose L, Johnson AD, Ridker PM, Chasman DI. Discovery and replication of novel blood pressure genetic loci in the women’s genome health study. J Hypertens. 2011;29(1): 62–69.

    Article  CAS  Google Scholar 

  10. Wang Y, Zhang Y, Li Y, et al. Common variants in the ATP2B1 gene are associated with hypertension and arterial stiffness in Chinese population. Mol Biol Rep. 2013;40(2):1867–1873.

    Article  CAS  Google Scholar 

  11. Xi B, Tang W, Wang Q. Polymorphism near the ATP2B1 gene is associated with hypertension risk in East Asians: a meta-analysis involving 15 909 cases and 18 529 controls. Blood Press. 2012; 21(2):134–138.

    Article  CAS  Google Scholar 

  12. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. Obstet Gynecol. 2002;99(1):159–167.

    Google Scholar 

  13. Tabara Y1, Kohara K, Miki T. Millennium Genome Project for Hypertension. Hunting for genes for hypertension: the millennium genome project for hypertension. Hypertens Res. 2012;35(6):567–573.

    Article  CAS  Google Scholar 

  14. Kobayashi Y, Hirawa N, Tabara Y, et al. Mice lacking hypertension candidate gene ATP2B1 in vascular smooth muscle cells show significant blood pressure elevation. Hypertension. 2012; 59(4):854–860.

    Article  CAS  Google Scholar 

  15. Kisters K, Barenbrock M, Louwen F, Hausberg M, Rahn KH, Kosch M. Membrane, intracellular, and plasma magnesium and calcium concentrations in preeclampsia. Am J Hypertens. 2000; 13(7):765–769.

    Article  CAS  Google Scholar 

  16. Kisters K, Korner J, Louwen F, et al. Plasma and membrane Ca2+ and Mg2+ concentrations in normal pregnancy and in preeclampsia. Gynecol Obstet Invest. 1998;46(3):158–163.

    Article  CAS  Google Scholar 

  17. Steinert JR, Wyatt AW, Poston L, Jacob R, Mann GE. Preeclampsia is associated with altered Ca2+ regulation and NO production in human fetal venous endothelial cells. Faseb J 2002;16:721–3.

    Article  CAS  Google Scholar 

  18. Idogun ES, Imarengiaye CO, Momoh SM. Extracellular calcium and magnesium in preeclampsia and eclampsia. Afr J Reprod Health. 2007;11(2):89–94.

    Article  CAS  Google Scholar 

  19. Nardulli G, Proverbio F, Limongi FG, Marin R, Proverbio T. Preeclampsia and calcium adenosine triphosphatase activity of red blood cell ghosts. Am J Obstet Gynecol. 1994;171(5): 1361–1365.

    Article  CAS  Google Scholar 

  20. Casart Y, Proverbio T, Marin R, Proverbio F. Comparative study of the calcium adenosine triphosphatase of basal membranes of human placental trophoblasts from normotensive and preeclamptic pregnant women. Gynecol Obstet Invest. 2001;51(1): 28–31.

    Article  CAS  Google Scholar 

  21. Carreiras MM, Proverbio T, Proverbio F, Marin R. Preeclampsia and calcium-ATPase activity of red cell ghosts from neonatal and maternal blood. Hypertens Pregnancy. 2002;21(2):97–107.

    Article  CAS  Google Scholar 

  22. Carrera F, Casart YC, Proverbio T, Proverbio F, Marin R. Preeclampsia and calcium-ATPase activity of plasma membranes from human myometrium and placental trophoblast. Hypertens Pregnancy. 2003;22(3):295–304.

    Article  CAS  Google Scholar 

  23. Hernandez-Diaz S, Toh S, Cnattingius S. Risk of pre-eclampsia in first and subsequent pregnancies: prospective cohort study. BMJ. 2009;338:b2255.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, 250021, Jinan, China

    Ji-Peng Wan MD, PhD, Hong Wang MD, Chang-Zhong Li MD, PhD, Dong-Hong Shi MD, Hong Lv MD, PhD, Fei Wang MD, PhD, Ze-Qing Wen MD & Xie-Tong Wang MD, PhD

  2. Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China

    Han Zhao MD, PhD, Li You MD, PhD & Zi-Jiang Chen MD, PhD

  3. National Research Center for Assisted Reproductive Technology and Reproductive Genetics, China

    Han Zhao MD, PhD, Li You MD, PhD & Zi-Jiang Chen MD, PhD

  4. The Key laboratory for Reproductive Endocrinology of Ministry of Education, China

    Han Zhao MD, PhD, Li You MD, PhD & Zi-Jiang Chen MD, PhD

  5. Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China

    Han Zhao MD, PhD, Li You MD, PhD & Zi-Jiang Chen MD, PhD

  6. Department of Obstetrics and Gynecology, Qingdao Municipal Hospital, Qingdao, China

    Xiu-Hua Sun MD

Authors
  1. Ji-Peng Wan MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hong Wang MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chang-Zhong Li MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Han Zhao MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Li You MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Dong-Hong Shi MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Xiu-Hua Sun MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hong Lv MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Fei Wang MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Ze-Qing Wen MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Xie-Tong Wang MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Zi-Jiang Chen MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xie-Tong Wang MD, PhD.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wan, JP., Wang, H., Li, CZ. et al. The Common Single-Nucleotide Polymorphism rs2681472 Is Associated With Early-Onset Preeclampsia in Northern Han Chinese Women. Reprod. Sci. 21, 1423–1427 (2014). https://doi.org/10.1177/1933719114527354

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1177/1933719114527354

Keywords

Search

Navigation