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The Emerging Roles of Adiponectin in Female Reproductive System-Associated Disorders and Pregnancy

Reproductive Sciences volume 20, pages 872–881 (2013)Cite this article

Abstract

Adiponectin, the most abundant adipose-released cytokine, has an important role in metabolism, primarily through reducing insulin resistance. Reproductive functions are known to be influenced by energy balance and adiponectin may be involved in the underlying mechanisms connecting reproduction and metabolism. Interestingly, adiponectin has been shown to exert actions in the female reproductive system, including the hypothalamic—pituitary—ovarian axis and the endometrium. The peripheral effects of this adipocytokine are mediated mainly via 2 receptors, AdipoR1 and AdipoR2. The expression of these receptors has been reported in the brain, ovaries, endometrium, and the placenta. Thus, adiponectin may influence fertility and pregnancy. Furthermore, adiponectin concentrations and effects have been assessed in some pregnancy-associated disorders and gynecological conditions. The findings may lead to the use of adiponectin or its receptors as therapeutic targets in novel treatment strategies of these disorders.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Medical School, University of Thessalia, 41110, Mezourlo, Larissa, Greece

    George Angelidis MD, Varvara Valotassiou MD, Dimitrios Psimadas MSc & Panagiotis Georgoulias MD

  2. Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece

    Konstantinos Dafopoulos MD, Christina I. Messini MD & Ioannis E. Messinis MD, PhD

  3. Department of Obstetrics and Gynecology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece

    Panagiotis Tsikouras MD

  4. Department of Obstetrics and Gynecology, Medical School, National and Kapodestrian University of Athens, Athens, Greece

    Nikolaos Vrachnis MD

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  1. George Angelidis MD
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  2. Konstantinos Dafopoulos MD
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  3. Christina I. Messini MD
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  4. Varvara Valotassiou MD
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  5. Panagiotis Tsikouras MD
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  6. Nikolaos Vrachnis MD
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  7. Dimitrios Psimadas MSc
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  8. Panagiotis Georgoulias MD
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  9. Ioannis E. Messinis MD, PhD
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Correspondence to George Angelidis MD.

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Angelidis, G., Dafopoulos, K., Messini, C.I. et al. The Emerging Roles of Adiponectin in Female Reproductive System-Associated Disorders and Pregnancy. Reprod. Sci. 20, 872–881 (2013). https://doi.org/10.1177/1933719112468954

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  • DOI: https://doi.org/10.1177/1933719112468954

Keywords

  • adiponectin
  • gonadotropins
  • pregnancy
  • fertility

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