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Genetic Variants in TEX15 Gene Conferred Susceptibility to Spermatogenic Failure in the Chinese Han Population

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Abstract

This study aimed to analyze the distribution of single-nucleotide polymorphisms (SNPs) of testis-expressed 15 (TEX15) gene in the Chinese Han infertile men and fertile men. This case–control study comprised 309 infertile men with nonobstructive azoospermia (NOA, n = 199) or severe oligozoospermia (SO, n = 110) and 377 fertile controls. Six SNPs were genotyped by Sequenom iplex technology. The results showed that the variants rs323346 and rs323347 contributed to the increasing risk of SO (P = .041, odds ratio [OR] = 1.635, 95% confidence interval [CI] = 1.018–2.628 and P = .046, OR = 1.616, 95% CI = 1.006-2.597). The haplotype AT of the SNPs rs323347 and rs323346 could reduce risk in the patients with SO (P = .040, OR = 0.616, and 95% CI = 0.383–0.990). The haplotype GC of the variants rs323347 and rs323346 conferred a significantly increased risk of SO (P = .040, OR = 1.624, 95% CI = 1.010–2.610). Thus, the polymorphisms rs323346 and rs323347 of the TEX15 gene could be considered the genetic risk factors for spermatogenic failure in the Chinese Han population.

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  1. The authors contributed equally to this manuscript.

Authors and Affiliations

  1. Key Lab of Genome Research of Anhui Province, Anhui Medical University, 230032, Hefei, China

    Jian Ruan MS, Wei-Dong Du MD, Yuan Zhou MS & Song Xu MS

  2. Department of Biology, Anhui Medical University, Hefei, China

    Jian Ruan MS, Yuan Zhou MS, Song Xu MS & Li-Bin Fang PhD

  3. Reproduction Medical Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China

    Xiao-Jin He MD & Yun-Xia Cao MD, PhD

  4. State Key Laboratory Incubation Base of Dermatology, Ministry of National Science and Technology, Hefei, China

    Wei-Dong Du MD, Gang Chen MS, Xian-Bo Zuo MS & Xue-Jun Zhang MD, PhD

  5. Sektion Experimentelle Anaesthesiologie, Universitaetsklinikum Ulm, Ulm, Germany

    Wei-Dong Du MD

Authors
  1. Jian Ruan MS
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  2. Xiao-Jin He MD
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  4. Gang Chen MS
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  5. Yuan Zhou MS
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  6. Song Xu MS
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  7. Xian-Bo Zuo MS
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  8. Li-Bin Fang PhD
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  9. Yun-Xia Cao MD, PhD
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  10. Xue-Jun Zhang MD, PhD
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Correspondence to Wei-Dong Du MD or Yun-Xia Cao MD, PhD.

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Ruan, J., He, XJ., Du, WD. et al. Genetic Variants in TEX15 Gene Conferred Susceptibility to Spermatogenic Failure in the Chinese Han Population. Reprod. Sci. 19, 1190–1196 (2012). https://doi.org/10.1177/1933719112446076

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  • DOI: https://doi.org/10.1177/1933719112446076

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