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Maternal and Fetal Thrombophilia in Intrauterine Growth Restriction in the Presence or Absence of Maternal Hypertensive Disease

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Abstract

Intrauterine growth restriction (IUGR) depends on the placental capacity to transfer oxygen and nutrients from the maternal to the fetal circulation. Placental insufficiency may be caused by impairment of the maternal or fetal circulation by a thrombotic event, possibly associated with thrombophilic disorders. The goals of our study were to define the role of maternal/fetal gain-of-function factor V Leiden and prothrombin G20210A mutations in the development of IUGR and to evaluate whether maternal pregnancy-induced hypertensive diseases would modify any such association. This is a case—control study: controls were 259 normal pregnancies, cases were 77 IUGR, 28 with and 49 without preeclampsia (PE) or pregnancy-induced hypertension (PIH). An association was found between IUGR and fetal thrombophilia (OR 2.09 CI 95% 1–4.5). The association was stronger in IUGR without PE and PIH (OR 2.9 CI 95% 1.3–6.6). This suggests a role for the fetal genotype in the development of IUGR.

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Authors and Affiliations

  1. Unit of Obstetrics and Gynecology, Department of Clinical Sciences, Hospital Luigi Sacco, and Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Medicine and Medical Specialties, University of Milan, Milan, Italy

    Paola Pileri MD, Chiara Mandò PhD & Patrizio Antonazzo MD, PhD

  2. IRCCS Policlinico, Mangiagalli and Regina Elena Foundation, Milan, Italy

    Franca Franchi BSc, Buthaina Ibrahim BSN, Federica Rossi BSN & Eugenia Biguzzi MD

  3. Ostetricia e Ginecologia, Ospedale Luigi Sacco, Via G.B. Grassi 74, 20157, Milan, Italy

    Irene Cetin MD, PhD

Authors
  1. Paola Pileri MD
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  2. Franca Franchi BSc
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  3. Irene Cetin MD, PhD
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  4. Chiara Mandò PhD
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  5. Patrizio Antonazzo MD, PhD
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  6. Buthaina Ibrahim BSN
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  7. Federica Rossi BSN
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  8. Eugenia Biguzzi MD
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Corresponding author

Correspondence to Irene Cetin MD, PhD.

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Pileri, P., Franchi, F., Cetin, I. et al. Maternal and Fetal Thrombophilia in Intrauterine Growth Restriction in the Presence or Absence of Maternal Hypertensive Disease. Reprod. Sci. 17, 844–848 (2010). https://doi.org/10.1177/1933719110371516

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  • DOI: https://doi.org/10.1177/1933719110371516

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