Plasma Levels of β-Endorphin During Pregnancy and Use of Labor Analgesia

Abstract

β-endorphins are endogenous opioid substances produced by the pituitary gland and placenta. The aims of this project were to longitudinally follow plasma levels of β-endorphin during pregnancy in women with a healthy pregnancy and to investigate whether plasma levels of β-endorphin in late pregnancy are associated with need for additional pain medication beyond nitrous oxide during labor. Plasma samples from 45 women were collected at gestational weeks 10, 25, 28, 33 and 37, and β-endorphin was analyzed by radioimmunoassay (RIA). Plasma levels of β-endorphin displayed a significant decrease in gestational weeks 28 and 33 compared to week 10, followed by a subsequent increase between gestational weeks 28 and 37. However, there was no change in levels of β-endorphin between gestational weeks 10 and 37. Low levels of β-endorphin at the end of pregnancy were associated with need for additional pain medication beyond nitrous oxide during labor, although the causal relationship is unclear.

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References

  1. 1.

    Gintzler. Endorphin-mediated increases in pain threshold during pregnancy. Science. 1980;210(4466):193–195.

    CAS  Article  Google Scholar 

  2. 2.

    Goolkasian PRB. Pain reactions in pregnant women. Pain. 1984;20(1):87–95.

    CAS  Article  Google Scholar 

  3. 3.

    Cogan R, Spinnato JA. Pain and discomfort thresholds in late pregnancy. Pain. 1986;27(1):63–68.

    CAS  Article  Google Scholar 

  4. 4.

    Carvalho B, Wang P, Cohen SE. A survey of labor patient-controlled epidural anesthesia practice in California hospitals. Int J Obstet Anesth. 2006;15(3):217–222.

    CAS  Article  Google Scholar 

  5. 5.

    Ohel I, Walfisch A, Shitenberg D, Sheiner E, Hallak M. A rise in pain threshold during labor: a prospective clinical trial. Pain. 2007;132(suppl 1):S104–S108.

    Article  Google Scholar 

  6. 6.

    Imura H, Nakai Y. “Endorphins” in pituitary and other tissues. Annu Rev Physiol. 1981;43:265–278.

    CAS  Article  Google Scholar 

  7. 7.

    Krieger DT. Placenta as a source of ‘brain’ and ‘pituitary’ hormones. Biol Reprod. 1982;26(1):55–71.

    CAS  Article  Google Scholar 

  8. 8.

    Hofmeyr GJ, Gülmezoglu AM, Nikodem VC, Van der Spuy ZM, Hendricks MS. Labor experience and beta-endorphin levels. Int J Gynecol Obstet. 1995;50(3):299–300.

    CAS  Article  Google Scholar 

  9. 9.

    Goebelsmann U, Abboud TK, Hoffman DI, Hung TT. Beta-endorphin in pregnancy. Eur J Obstet Gynecol Reprod Biol. 1984;17(2–3):77–89.

    CAS  Article  Google Scholar 

  10. 10.

    Hoffman DI, Abboud TK, Haase HR, Hung TT, Goebelsmann U. Plasma beta-endorphin concentrations prior to and during pregnancy, in labor, and after delivery. Am J Obstet Gynecol. 1984;150(5 pt 1):492–496.

    CAS  Article  Google Scholar 

  11. 11.

    Goland RS, Wardlaw SL, Stark RI, Frantz AG. Human plasma beta-endorphin during pregnancy, labor, and delivery. J Clin Endocrinol Metab. 1981;52(1):74–78.

    CAS  Article  Google Scholar 

  12. 12.

    Csontos K, Rust M, Hollt V, Mahr W, Kromer W, Teschemacher HJ. Elevated plasma beta-endorphin levels in pregnant women and their neonates. Life Sci. 1979;25(10):835–844.

    CAS  Article  Google Scholar 

  13. 13.

    Genazzani AR, Facchinetti F, Parrini D. Beta-lipotrophin and beta-endorphin plasma levels during pregnancy. Clin Endocrinol (Oxf). 1981;14(4):409–418.

    CAS  Article  Google Scholar 

  14. 14.

    Browning AJ, Butt WR, Lynch SS, Shakespear RA. Maternal plasma concentrations of beta-lipotrophin, beta-endorphin and gamma-lipotrophin throughout pregnancy. Br J Obstet Gynaecol. 1983;90(12):1147–1151.

    CAS  Article  Google Scholar 

  15. 15.

    Sandman CA GL, Wadhwa PD, Chicz-DeMet A, Porto M, Garite T. Third trimester POMC disregulation predicts use of anesthesia at vaginal delivery. Peptides. 1995;16(2):187–190.

    CAS  Article  Google Scholar 

  16. 16.

    Varrassi G, Bazzano C, Edwards WT. Effects of physical activity on maternal plasma beta-endorphin levels and perception of labor pain. Am J Obstet Gynecol. 1989;160(3):707–712.

    CAS  Article  Google Scholar 

  17. 17.

    Glamsta EL, Morkrid L, Lantz I, Nyberg F. Concomitant increase in blood plasma levels of immunoreactive hemorphin-7 and beta-endorphin following long distance running. Regul Pept. 1993;49(1):9–18.

    CAS  Article  Google Scholar 

  18. 18.

    Wuitchik M, Hesson K, Bakal DA. Perinatal predictors of pain and distress during labor. Birth. 1990;17(4):186–191.

    CAS  Article  Google Scholar 

  19. 19.

    McCrea H, Wright ME, Stringer M. Psychosocial factors influencing personal control in pain relief. Int J Nurs Stud. 2000;37(6):493–503.

    CAS  Article  Google Scholar 

  20. 20.

    Rowlands S, Permezel M. Physiology of pain in labour. Baillieres Clin Obstet Gynaecol. 1998;12(3):347–362.

    CAS  Article  Google Scholar 

  21. 21.

    Waldenstrom U, Bergman V, Vasell G. The complexity of labor pain: experiences of 278 women. J Psychosom Obstet Gynaecol. 1996;17(4):215–228.

    CAS  Article  Google Scholar 

  22. 22.

    McLean M, Thompson D, Zhang HP, Brinsmead M, Smith R. Corticotrophin-releasing hormone and beta-endorphin in labour. Eur J Endocrinol. 1994;131(2):167–172.

    CAS  Article  Google Scholar 

  23. 23.

    Goldfarb AH, Jamurtas AZ. Beta-endorphin response to exercise. An update. Sports Med. 1997;24(1):8–16.

    CAS  Article  Google Scholar 

  24. 24.

    Hegadoren KM, O’Donnell T, Lanius R, Coupland N, Lacaze-Masmonteil NJ. The role of beta-endorphin in the pathophysiology of major depression. Neuropeptides. 2009;43(5):341–353.

    CAS  Article  Google Scholar 

  25. 25.

    Vogl SE, Worda C, Egarter C, et al. Mode of delivery is associated with maternal and fetal endocrine stress response. BJOG. 2006;113(4):441–445.

    CAS  Article  Google Scholar 

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Correspondence to Helena Åkerud MD, PhD.

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Dabo, F., Nyberg, F., Zhou, Q. et al. Plasma Levels of β-Endorphin During Pregnancy and Use of Labor Analgesia. Reprod. Sci. 17, 742–747 (2010). https://doi.org/10.1177/1933719110370059

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Keywords

  • Analgesia
  • β-endorphin
  • labor
  • pain
  • pregnancy