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Responses of Amniotic Fluid Volume and Its Four Major Flows to Lung Liquid Diversion and Amniotic Infusion in the Ovine Fetus

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Abstract

We designed experiments to allow direct measurement of amniotic fluid volume and continuous measurement of lung liquid production, swallowing, and urine production in fetal sheep. From these values, the rate of intramembranous absorption was calculated. Using this experimental design, the contribution of lung liquid to the control of amniotic fluid volume was examined. Fetuses were assigned to 1 of 4 protocols, each protocol lasting 3 days: control, isovolemic replacement of lung liquid, supplementation of amniotic fluid inflow by 4 L/day, and supplementation of amniotic inflow during isovolemic replacement of lung liquid. We found no effect of lung liquid replacement on any of the known flows into and out of the amniotic fluid. Although intramembranous absorption increased greatly during supplementation, the amniochorionic function curves were not altered by isovolemic lung liquid replacement. We conclude that lung liquid does not appear to contain a significant regulatory substance for amniotic fluid volume control.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, USA

    Patricia Robertson MD, Robert A. Brace PhD, A. Roger Hohimer PhD & Lowell E. Davis MD

  2. Heart Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon, 97239, USA

    J. Job Faber MD, PhD, Samantha Louey PhD & Debra F. Anderson PhD

Authors
  1. Patricia Robertson MD
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  2. J. Job Faber MD, PhD
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  3. Robert A. Brace PhD
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  4. Samantha Louey PhD
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  5. A. Roger Hohimer PhD
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  6. Lowell E. Davis MD
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  7. Debra F. Anderson PhD
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Corresponding author

Correspondence to Debra F. Anderson PhD.

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Robertson, P., Faber, J.J., Brace, R.A. et al. Responses of Amniotic Fluid Volume and Its Four Major Flows to Lung Liquid Diversion and Amniotic Infusion in the Ovine Fetus. Reprod. Sci. 16, 88–93 (2009). https://doi.org/10.1177/1933719108324888

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  • DOI: https://doi.org/10.1177/1933719108324888

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