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Plasma and Renal Renin Concentrations in Adult Sheep After Prenatal Betamethasone Exposure

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Abstract

This study examined whether renin expression and secretion and plasma angiotensin II (Ang II) levels were altered in adult sheep exposed to antenatal betamethasone. Pregnant sheep received injections of 0.17 mg/kg betamethasone or vehicle, at 80 and 81 days of gestation, and offspring were studied at 6 and 18 months of age. At 6 months, plasma prorenin concentrations were significantly lower in betamethasone animals (4.63 ± 0.64 vs 7.09 ± 0.83 ng angiotensin I/mL/h, P < .01). The percentage of plasma active renin was significantly higher in the betamethasone group (31.93 ± 4.09% vs 18.57 ± 2.79%, P < .01). Plasma and renocortical renin levels were similar in both groups at 18 months, but plasma renin activity was lower than at 6 months. Ang II levels were suppressed by betamethasone. The data indicate that prenatal exposure to betamethasone alters processing and secretion of renin in offspring at 6 months, but that this difference is not apparent at 18 months.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, 27157, USA

    Lucia Kantorowicz MD, Nancy K. Valego PhD, LiJun Tang PhD, Jorge P. Figueroa MD, PhD, Luke C. Carey PhD & James C. Rose PhD

  2. Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA

    James C. Rose PhD

  3. Center of Research for Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA

    Lucia Kantorowicz MD, Nancy K. Valego PhD, LiJun Tang PhD, Jorge P. Figueroa MD, PhD & Luke C. Carey PhD

  4. Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA

    Mark C. Chappell PhD

Authors
  1. Lucia Kantorowicz MD
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  2. Nancy K. Valego PhD
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  3. LiJun Tang PhD
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  4. Jorge P. Figueroa MD, PhD
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  5. Mark C. Chappell PhD
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  6. Luke C. Carey PhD
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  7. James C. Rose PhD
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Corresponding author

Correspondence to James C. Rose PhD.

Additional information

This research was supported by NIH grants HD17644 and HD47584.

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Kantorowicz, L., Valego, N.K., Tang, L. et al. Plasma and Renal Renin Concentrations in Adult Sheep After Prenatal Betamethasone Exposure. Reprod. Sci. 15, 831–838 (2008). https://doi.org/10.1177/1933719108318599

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  • DOI: https://doi.org/10.1177/1933719108318599

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