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The Relation Between Venous Reserve Capacity and Low Plasma Volume

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Abstract

Objective: Prepregnant low plasma volume (LPV) is associated with subsequent gestational hypertensive disease. It is unknown to what extent an LPV affects the venous reserve capacity (VRC). We tested the hypothesis that LPV reduces the VRC, as indicated by presyncope or altered cardiovascular changes in response to head-up tilt. Study design: In 52 nonpregnant women with a history of preeclampsia or recurrent miscarriage, the authors assessed plasma volume, stroke volume, and cardiac output and determined blood pressure, heart rate, and autonomic responses to stepwise inflicted head-up tilt. Results: 12 participants had LPV, which related to presyncope when compared with subjects with normal plasma volume (NPV). Women with LPV without presyncope demonstrated a circulatory response comparable to NPV women at the expense of consistently higher heart rate. Conclusion: LPV decreases the capacity to cope with head-up tilt without affecting the response pattern, suggesting reduced VRC.

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, Internal Postal Code 791, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands

    Ineke Krabbendam MD, Henk W. Jongsma PhD, Fred K. Lotgering MD, PhD & Marc E. A. Spaanderman MD, PhD

  2. Department of Cardiology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands

    Arie P. J. Van Dijk MD, PhD

  3. Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands

    Wim J. G. Oyen MD, PhD

  4. Department of Pharmacology and Toxicology, University of Maastricht, Maastricht, the Netherlands

    Ben J. Janssen PhD

Authors
  1. Ineke Krabbendam MD
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  2. Ben J. Janssen PhD
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  3. Arie P. J. Van Dijk MD, PhD
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  4. Henk W. Jongsma PhD
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  5. Wim J. G. Oyen MD, PhD
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  6. Fred K. Lotgering MD, PhD
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  7. Marc E. A. Spaanderman MD, PhD
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Correspondence to Ineke Krabbendam MD.

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Krabbendam, I., Janssen, B.J., Van Dijk, A.P.J. et al. The Relation Between Venous Reserve Capacity and Low Plasma Volume. Reprod. Sci. 15, 604–612 (2008). https://doi.org/10.1177/1933719108316983

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