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Toll-like Receptors and Pregnancy

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References

  1. Abrahams VM, Bole-Aldo P, Kim YM, et al. Divergent trophoblast responses to bacterial products mediated by TLRs. J Immunol. 2004;173:4286–4296.

    Article  CAS  Google Scholar 

  2. Abrahams VM, Visintin I, Aldo PB, Guller S, Romero R, Mor G. A role for TLRs in the regulation of immune cell migration by first trimester trophoblast cells. J Immunol. 2005;175: 8096–8104.

    Article  CAS  Google Scholar 

  3. Abrahams VM, Romero R, Mor G. TLR-3 and TLR-4 mediate differential chemokine production and immune cell recruitment by first trimester trophoblast cells. Am J Reprod Immunol. 2005;53:279. Abstract ASRI205-202.

    Article  Google Scholar 

  4. Mor G, Romero R, Aldo PB, Abrahams VM. Is the trophoblast an immune regulator? The role of toll-like receptors during pregnancy. Crit Rev Immunol. 2005;25:375–388.

    Article  CAS  Google Scholar 

  5. Romero R, Maymon E, Pacora P, et al. Further observations on the fetal inflammatory response syndrome: a potential homeostatic role for the soluble receptors of tumor necrosis factor alpha. Am J Obstet Gynecol. 2000;183:1070–1077.

    Article  CAS  Google Scholar 

  6. Davies JK, Shikes RH, Sze CI, et al. Histologic inflammation in the maternal and fetal compartments in a rabbit model of acute intra-amniotic infection. Am J Obstet Gynecol. 2000;183: 1088–1093.

    Article  CAS  Google Scholar 

  7. Goncalves LF, Chaiworapongsa T, Romero R. Intrauterine infection and prematurity. Ment Retard Dev Disabil Res Rev. 2002;8:3–13.

    Article  Google Scholar 

  8. Romero R, Chaiworapongsa T, Espinoza J. Micronutrients and intrauterine infection, preterm birth and the fetal inflammatory response syndrome. J Nutr. 2003;133:1668S–1673S.

    Article  CAS  Google Scholar 

  9. von Dadelszen P, Magee LA, Krajden M, et al. Levels of antibodies against cytomegalovirus and Chlamydophila pneumoniae are increased in early onset pre-eclampsia. BJOG. 2003;110: 725–730.

    Article  Google Scholar 

  10. Hsu CD, Witter FR. Urogenital infection in preeclampsia. Int J Gynaecol Obstet. 1995;49:271–275.

    Article  CAS  Google Scholar 

  11. Arechavaleta-Velasco F, Koi H, Strauss JF III, Parry S. Viral infection of the trophoblast: time to take a serious look at its role in abnormal implantation and placentation? J Reprod Immunol. 2002;55:113–121.

    Article  Google Scholar 

  12. Lamont RF. Infection in the prediction and antibiotics in the prevention of spontaneous preterm labour and preterm birth. BJOG. 2003;110(suppl 20):71–75.

    Article  Google Scholar 

  13. Goldenberg RL, Hauth JC, Andrews WW. Intrauterine infection and preterm delivery. N Engl J Med. 2000;342:1500–1507.

    Article  CAS  Google Scholar 

  14. Abrahams VM, Fahey JV, Schaefer TM, Wright JA, Wira CR, Mor G. Stimulation of first trimester trophoblast cells with poly(I:C) induces SLPI secretion. Am J Reprod Immunol. 2005;53:280. Abstract ASRI205-204.

    Google Scholar 

  15. Fest S, Aldo PB, Abrahams VM, et al.Trophoblast-macrophage interactions: a regulatory network for the protection of pregnancy. Am J Reprod Immunol. 2007;57:55–66.

    Article  Google Scholar 

  16. Zarember KA, Godowski PJ. Tissue expression of human toll-like receptors and differential regulation of toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J Immunol. 2002;168:554–561.

    Article  CAS  Google Scholar 

  17. Hoshino K, Takeuchi O, Kawai T, et al. Cutting edge: toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol. 1999;162:3749–3752.

    CAS  PubMed  Google Scholar 

  18. Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol. 2004;4:499–511.

    Article  CAS  Google Scholar 

  19. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NFkappaB by toll-like receptor 3. Nature. 2001;413:732–738.

    Article  CAS  Google Scholar 

  20. Uematsu S, Akira S. Toll-like receptors and innate immunity. J Mol Med. 2006;84:712–725.

    Article  CAS  Google Scholar 

  21. Yamamoto M, Sato S, Hemmi H, et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science. 2003;301:640–643.

    Article  CAS  Google Scholar 

  22. Takeuchi O, Hoshino K, Kawai T, et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity. 1999;11: 443–451.

    Article  CAS  Google Scholar 

  23. Kawai T, Sato S, Ishii KJ, et al. Interferon-alpha induction through toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol. 2004;5:1061–1068.

    Article  CAS  Google Scholar 

  24. Ilievski V, Lu S-J, Hirsch E. Activation of toll-like receptors 2 or 3 and preterm delivery in the mouse. Reprod Sci. 2007; 14:315–320.

    CAS  Google Scholar 

  25. Kim YM, Romero R, Chaiworapongsa T, et al. Toll-like receptor-2 and -4 in the chorioamniotic membranes in spontaneous labor at term and in preterm parturition that are associated with chorioamnionitis. Am J Obstet Gynecol. 2004; 191:1346–1355.

    Article  CAS  Google Scholar 

  26. Kim YM, Romero R, Oh SY, et al. Toll-like receptor 4: a potential link between “danger signals,” the innate immune system, and preeclampsia? Am J Obstet Gynecol. 2005;193: 921–928.

    Article  CAS  Google Scholar 

  27. Straszewski-Chavez SL, Abrahams VM, Mor G. The role of apoptosis in the regulation of trophoblast survival and differentiation during pregnancy. Endocr Rev. 2005;26:877–897.

    Article  CAS  Google Scholar 

  28. Abrahams VM, Schaefer TM, Fahey JV, et al. Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, poly(I:C). Hum Reprod. 2006;21:2432–2439.

    Article  CAS  Google Scholar 

  29. Hirata T, Osuga Y, Hamasaki K, et al. Expression of toll-like receptors 2, 3, 4, and 9 genes in the human endometrium during the menstrual cycle. J Reprod Immunol. 2007;74:53–60.

    Article  CAS  Google Scholar 

  30. Pioli PA, Amiel E, Schaefer TM, Connolly JE, Wira CR, Guyre PM. Differential expression of toll-like receptors 2 and 4 in tissues of the human female reproductive tract. Infect Immun. 2004;72:5799–5806.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics Gynecology and Reproductive Sciences, Yale University, School of Medicine, 310 Cedar Street, New Haven, Connecticut, 06510, USA

    Kaori Koga MD, PhD & Gil Mor MD, PhD

Authors
  1. Kaori Koga MD, PhD
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  2. Gil Mor MD, PhD
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Corresponding author

Correspondence to Gil Mor MD, PhD.

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Koga, K., Mor, G. Toll-like Receptors and Pregnancy. Reprod. Sci. 14, 297–299 (2007). https://doi.org/10.1177/1933719107304562

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