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Transforming Growth Factor β1 Gene Polymorphism —509C/T in Deep Infiltrating Endometriosis

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Abstract

Deep infiltrating endometriosis is characterized by the presence of nodular lesions largely composed of fibromuscular tissue. Transforming growth factor beta 1 (TGF-β1) is the cytokine most causatively associated with disorders characterized by fibrosis throughout the body. Therefore, the hypothesis was tested that mechanisms increasing the fraction of biologically active TGF-β1, such as TGF-β1 gene polymorphisms, lead to an increased risk of developing deep infiltrating endometriosis. The frequency of the −509C/T polymorphism of the TGF-β1 gene was tested in women with deep infiltrating endometriosis (n = 72), gynecological patients without symptoms of endometriosis (n = 95) and healthy females (n = 93). Detection of the −509C/T polymorphisms was performed using PCR-restriction fragment length polymorphism analysis. We did not observe statistically significant differences in the frequency of the −509C/T polymorphism between the groups. Our study does not support an association between the −509C/T polymorphism of the TGF-β1 gene and an increased risk of deep infiltrating endometriosis.

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Authors and Affiliations

  1. Research Institute GROW, University of Maastricht, Maastricht, Netherlands

    K. J. A. F. van Kaam MD, A. Romano PhD, G. A. J. Dunselman MD, PhD & P. G. Groothuis PhD

  2. Department of Obstetrics and Gynaecology, University Hospital of Maastricht, P. Debyelaan 25, 6202 AZ, Maastricht, Netherlands

    K. J. A. F. van Kaam MD, A. Romano PhD, G. A. J. Dunselman MD, PhD & P. G. Groothuis PhD

Authors
  1. K. J. A. F. van Kaam MD
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  2. A. Romano PhD
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  3. G. A. J. Dunselman MD, PhD
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  4. P. G. Groothuis PhD
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Correspondence to K. J. A. F. van Kaam MD.

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van Kaam, K.J.A.F., Romano, A., Dunselman, G.A.J. et al. Transforming Growth Factor β1 Gene Polymorphism —509C/T in Deep Infiltrating Endometriosis. Reprod. Sci. 14, 367–373 (2007). https://doi.org/10.1177/1933719107303436

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