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Antepartum and Postpartum Thrombomodulin Levels in Preeclamptic and Normotensive Pregnancies

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Abstract

OBJECTIVE

TO determine whether changes in plasma levels of thrombomodulin from antepartum to postpartum reflect the postpartum regression of preeclampsia.

METHODS

Twenty-four preeclamptic women and 34 healthy, normotensive women with singleton pregnancies were studied in the third trimester. Plasma levels of thrombomodulin in the antepartum and postpartum periods were measured by a two-site immunoenzymatic assay. Two-tailed Student t test and paired-comparison t test were used for statistical analyses. The results were expressed as mean ± standard error.

RESULTS

Antepartum plasma thrombomodulin levels in preeclampsia were significantly higher than postpartum levels (71.3 ± 8.5 versus 55.5 ±5.4 ng/mL; P =.006), which was not seen in the normotensive controls (49.9 ±3.1 versus 44.2 ±3.8 ng/mL; P >.05). Antepartum plasma levels of thrombomodulin in preeclamptic women were signiftcantly higher than those in the normotensive controls (P =.01). However, postpartum plasma levels of thrombomodulin in preeclamptic women were not significantly higher than those in the normotensive controls (P >.05).

CONCLUSION

Significantly decreased postpartum plasma thrombomodulin levels in preeclamptic pregnancies strongly correspond to clinical postpartum regression of preeclampsia. (J Soc Gynecol Invest 1997; 4:135-137) Copyright © 1997 by the Society for Gynecologic Investigation.

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Authors and Affiliations

  1. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Yale University School of Medicine, P.O. Box 208063, New Haven, CT, 06520-8063, USA

    Chaur-Dong Hsu MD, MPH, Joshua A. Copel MD & Daniel W. Chan PhD

  2. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Chaur-Dong Hsu MD, MPH, Joshua A. Copel MD & Daniel W. Chan PhD

Authors
  1. Chaur-Dong Hsu MD, MPH
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  2. Joshua A. Copel MD
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  3. Daniel W. Chan PhD
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Additional information

The authors thank Ms. Deborah Bruzek, Shih-Fen Hong, Drs. Greg Kaufman, Uma Reddy, and Sara Marder for their assistance.

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Hsu, CD., Copel, J.A. & Chan, D.W. Antepartum and Postpartum Thrombomodulin Levels in Preeclamptic and Normotensive Pregnancies. Reprod. Sci. 4, 135–137 (1997). https://doi.org/10.1177/107155769700400304

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