Abstract
Objective
To determine whether increased levels of maternal serum total activin A and inhibin A in preeclampsia are related to total blood volume, urinary clearance, or placental production.
Study Design
Activin A and inhibin A levels were measured in preeclamptic subjects and matched normotensive gravidas. In a subset of preeclamptic subjects (n = 21) and controls (n = 30), we performed blood volume studies. In an overlapping subject of preeclamptic subjects (n = 56), creatinine clearance results were available. Placental tissue was obtained from six preeclamptics and matched normotensive gravida for analysis of activin A and inhibin A mRNA expression.
Results
Maternal serum levels of inhibin A but not activin A were significantly negatively correlated with blood volume in preeclampsia (r2 = .26, P = 0.17, and r2 = .02, P = .44, respectively). Levels of both proteins were negatively correlated to creatinine clearance (r2 = .29, P < .0001, and r2 = .15, P = .003, respectively). Placental mRNA expression for both the α and βA subunits was increased in preeclampsia (P = .038 and .049, respectively).
Conclusion
Although placental mRNA expression of the subunits for both analytes is increased in preeclampsia, the increased levels of activin A appear to be more specifically a reflection of increased placental production than do the increased levels of inhibin A.
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Silver, H.M., Lambert-Messerlian, G.M., Reis, F.M. et al. Mechanism of Increased Maternal Serum Total Activin A and Inhibin A in Preeclampsia. Reprod. Sci. 9, 308–312 (2002). https://doi.org/10.1177/107155760200900509
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DOI: https://doi.org/10.1177/107155760200900509